2020
Biodistribution and internal radiation dosimetry of a novel probe for thymidine phosphorylase imaging, [123I]IIMU, in healthy volunteers
Watanabe S, Nishijima KI, Okamoto S, Magota K, Hirata K, Toyonaga T, Shiga T, Kuge Y, Tamaki N. Biodistribution and internal radiation dosimetry of a novel probe for thymidine phosphorylase imaging, [123I]IIMU, in healthy volunteers. Annals Of Nuclear Medicine 2020, 34: 595-599. PMID: 32361818, DOI: 10.1007/s12149-020-01469-4.Peer-Reviewed Original ResearchConceptsΜSv/MBqHealthy volunteersOLINDA/EXM 1.1 softwareEffective dosesWhole-body emission scansThymidine phosphorylaseResultsNo adverse eventsHealthy male adultsHigh uptakePotential clinical useMean effective dosesHigh-uptake organsAdverse eventsSingle doseInternal radiation dosimetryBlood samplesRenal systemTime-activity curvesHealthy adultsInjected activityScreening testNew radiotracersClinical useTime pointsMale adults
2019
Biodistribution and radiation dosimetry of the novel hypoxia PET probe [18F]DiFA and comparison with [18F]FMISO
Watanabe S, Shiga T, Hirata K, Magota K, Okamoto S, Toyonaga T, Higashikawa K, Yasui H, Kobayashi J, Nishijima KI, Iseki K, Matsumoto H, Kuge Y, Tamaki N. Biodistribution and radiation dosimetry of the novel hypoxia PET probe [18F]DiFA and comparison with [18F]FMISO. EJNMMI Research 2019, 9: 60. PMID: 31278504, PMCID: PMC6611855, DOI: 10.1186/s13550-019-0525-6.Peer-Reviewed Original ResearchPositron emission tomographyPreliminary clinical studyUrinary systemClinical studiesSequential whole-body scansTumor hypoxiaHypoxia tracerAbnormal clinical findingsΜSv/MBqDiagnostic abilityExcretion of radioactivityMean effective doseWhole-body scanGood inter-observer reproducibilityHealthy male adultsInter-observer reproducibilityMedical Internal Radiation Dose (MIRD) schemaAdverse eventsMulticenter trialClinical findingsSingle administrationMalignant tumorsUrinary bladderHealthy subjectsEmission tomography
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