Pharmacokinetic Exposure Equivalence and Preliminary Efficacy and Safety from a Randomized Cross over Phase 3 Study (ASCERTAIN study) of an Oral Hypomethylating Agent ASTX727 (cedazuridine/decitabine) Compared to IV Decitabine
Garcia-Manero G, McCloskey J, Griffiths E, Yee K, Zeidan A, Al-Kali A, Dao K, Deeg H, Patel P, Sabloff M, Keating M, Zhu N, Gabrail N, Fazal S, Maly J, Odenike O, Shastri A, DeZern A, O'Connell C, Roboz G, Oganesian A, Hao Y, Keer H, Azab M, Savona M. Pharmacokinetic Exposure Equivalence and Preliminary Efficacy and Safety from a Randomized Cross over Phase 3 Study (ASCERTAIN study) of an Oral Hypomethylating Agent ASTX727 (cedazuridine/decitabine) Compared to IV Decitabine. Blood 2019, 134: 846. DOI: 10.1182/blood-2019-122980.Peer-Reviewed Original ResearchPhase 3 studyFixed-dose combinationClinical trialsHematologic improvementAdverse eventsAstex PharmaceuticalsSpeakers bureauIncyte CorporationSafety findingsComplete responseRandomized crossOtsuka PharmaceuticalClinical activityHypomethylating agentOral fixed-dose combinationCelgene CorporationRandomized phase 3 studyBoehringer IngelheimAdvisory CommitteeSeattle GeneticsDaiichi SankyoClinic visit frequencyComparable clinical activityDifferent myeloid malignanciesPlatelet transfusion dependenceCommunity perspectives of South African adolescents’ experiences seeking treatment at local HIV clinics and how such clinics may influence engagement in the HIV treatment cascade: a qualitative study
Ritchwood T, Ba A, Ingram L, Atujuna M, Marcus R, Ntlapo N, Oduro A, Bekker L. Community perspectives of South African adolescents’ experiences seeking treatment at local HIV clinics and how such clinics may influence engagement in the HIV treatment cascade: a qualitative study. AIDS Care 2019, 32: 83-88. PMID: 31402674, PMCID: PMC6883151, DOI: 10.1080/09540121.2019.1653442.Peer-Reviewed Original ResearchConceptsHIV treatment cascadeClinic experienceClinic factorsTreatment cascadeSouth African adolescentsClinic environmentLargest antiretroviral treatment programmeClinic visit frequencyLocal HIV clinicsAntiretroviral treatment programAdolescents' experiencesAfrican adolescentsHIV careHIV clinicART adherenceLack of confidentialityTreatment programTreatment regimensTreatment retentionClinic staffSuch clinicsNegative aspectsClinic spaceClinic practiceStaff attitudes
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