2025
Non-fatal Overdose and Associated Factors Among People Who Use Opioids: Findings From a Cross-sectional Study
Sujan M, Wickersham J, Khati A, Paudel K, Gautam K, Liautaud D, Crim H, Thapa A, Copenhaver M, Shrestha R. Non-fatal Overdose and Associated Factors Among People Who Use Opioids: Findings From a Cross-sectional Study. Journal Of Community Health 2025, 1-10. PMID: 40381076, DOI: 10.1007/s10900-025-01480-8.Peer-Reviewed Original ResearchNon-fatal overdoseOpioid dependenceCross-sectional studySuicidal ideationHistory of opioid useOpioid overdoseAlcohol use disorderNon-fatal opioid overdoseMental health symptomsAge of participantsParticipants self-reportedHarm reduction interventionsSocio-demographic characteristicsOpioid useEffective prevention strategiesUse disorderDepressive symptomsTargeted harm reduction interventionsHealth symptomsMultivariate logistic regression analysisLogistic regression analysisReduction interventionsOlder participantsCross-sector collaborationRisk of overdose‘I don’t know what we should have done differently’: A qualitative study on the dilemmas of ‘tough love’ and toxic drugs in British Columbia, Canada
Hawkins J, Salmon A, Fernando S, Battle C, Esau S, Snyder D, Sikora M. ‘I don’t know what we should have done differently’: A qualitative study on the dilemmas of ‘tough love’ and toxic drugs in British Columbia, Canada. Drugs Education Prevention And Policy 2025, ahead-of-print: 1-10. DOI: 10.1080/09687637.2025.2493140.Peer-Reviewed Original ResearchSemi-structured qualitative interviewsPublic health emergencyRisk of overdoseQualitative studyQualitative interviewsSocial capitalBritish ColumbiaPsychosocial conceptsRelational negotiationDrug crisisPersonal agencyComplex negotiationsHealth emergencyDrug useIllicit drugsPersonal assetsPressure contextDrug deathsTheoretical frameworkPotential outcomesNegotiationLanguage influenceLoveCanadaCSO“You just want to kill the pain and get numb:” A mixed methods study investigating the lived experiences of individuals experiencing homelessness enrolled in outpatient methadone treatment
Gazzola M, Thompson E, Hoffman K, Saeed G, Baylen C, Madden L, Eggert K, Beitel M, Barry D. “You just want to kill the pain and get numb:” A mixed methods study investigating the lived experiences of individuals experiencing homelessness enrolled in outpatient methadone treatment. Journal Of Substance Use And Addiction Treatment 2025, 172: 209668. PMID: 40057243, DOI: 10.1016/j.josat.2025.209668.Peer-Reviewed Original ResearchOpioid use disorderPersonal barriersThematic analysisRisk of overdoseOpioid treatment programsStructural barriersPublic health priorityMixed methods studyHealth-related vulnerabilityExperience of homelessnessPeriods of homelessnessSemi-structured interviewsExperiences of individualsHealthcare experiencesHealth priorityParticipants' experiencesPrimary themesMethods studyImprove engagementMethadone treatmentDescriptive statisticsTreatment engagementQualitative interviewsExit homelessnessHousing statusState Policy Variation in Implementation of Federal Drug and Child Abuse Laws and Stigmatization of Pregnant and Postpartum Individuals with Opioid Use Disorder
Peltier M, Pegram D, Chander G, Weisner C, McKee S, Jones H, Chang G. State Policy Variation in Implementation of Federal Drug and Child Abuse Laws and Stigmatization of Pregnant and Postpartum Individuals with Opioid Use Disorder. Journal Of Women's Health 2025, 34: 613-621. PMID: 39932704, PMCID: PMC12136142, DOI: 10.1089/jwh.2024.0638.Peer-Reviewed Original ResearchOpioid use disorderChild abuse lawsChild abuse preventionRemoval of childrenAbuse lawsLegal actionCurrent legislationSubstance-exposed infantsComprehensive AddictionPunitive actionsIndividual statesRisk of overdoseAbuse preventionLegislationLife-saving medicationsLawState policyChild welfare workersSubstance useMandated trainingUse disorderMOUDIndividuals of colorPolicy variationReporting system
2024
‘It just doesn't stop’: Perspectives of women who use drugs on increased overdoses during the COVID‐19 pandemic
Speed K, McNeil R, Hayashi K, Maher L, Boyd J. ‘It just doesn't stop’: Perspectives of women who use drugs on increased overdoses during the COVID‐19 pandemic. Drug And Alcohol Review 2024, 44: 602-612. PMID: 39703005, PMCID: PMC11813672, DOI: 10.1111/dar.13996.Peer-Reviewed Original ResearchConceptsGender violenceSocio-economic marginalisationOverdose crisisDrug supplyPerspective of womenViolence frameworkExacerbate harmStructural driversSemi-structured interviewsViolenceCOVID-19 pandemicRisk of overdoseSocial distancing guidelinesReduced opportunitiesCrisisCOVID-19Health crisisOverdose riskWomenDistancing guidelinesIndividualised approachPublic health guidanceIncreasing overdoseHarmCOVID-19 environmentThe Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review
Jegede O, De Aquino J, Hsaio C, Caldwell E, Funaro M, Petrakis I, Muvvala S. The Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review. Journal Of Addiction Medicine 2024, 18: 499-510. PMID: 39356620, PMCID: PMC11449257, DOI: 10.1097/adm.0000000000001356.Peer-Reviewed Original ResearchNonmedical opioid useOpioid use disorderOpioid useWithdrawal symptomsTreatment outcomesSymptoms prior to treatmentUse disorderRisk of precipitated withdrawalLow-dose buprenorphineSynthetic opioidsPotency synthetic opioidsConclusions Current evidencePrecipitated withdrawalRisk of overdoseDosing strategiesPharmacological interactionsClinical significanceDecreased riskWeb of ScienceOpioidInclusion criteriaCurrent evidenceClinical implicationsMOUDPainPostrelease Risk of Overdose and All-Cause Death Among Persons Released From Jail or Prison: Minnesota, March 2020-December 2021.
Hill K, Bodurtha P, Winkelman T, Howell B. Postrelease Risk of Overdose and All-Cause Death Among Persons Released From Jail or Prison: Minnesota, March 2020-December 2021. American Journal Of Public Health 2024, 114: 913-922. PMID: 39024534, PMCID: PMC11306622, DOI: 10.2105/ajph.2024.307723.Peer-Reviewed Original ResearchConceptsOverdose deathsPrison exposureJailPrisonRisk of overdoseRates of overdose deathsOverdose death ratesOpioid use disorderGeneral populationDeath recordsDrug overdosePeopleStandardized mortality ratioPersonsIncarcerationUse disorderPostreleaseMortality ratioDeath rateRisk of deathRetrospective cohort studyMortality riskCohort studyMinnesotaOverdosePerspectives on benefits and risks of creation of an “injection drug use” billing code
Sundaram G, Sato T, Goodman-Meza D, Haddad M, Thakarar K, Feinberg J, Springer S, Barton K, Butler N, Eaton E, Wurcel A. Perspectives on benefits and risks of creation of an “injection drug use” billing code. Journal Of Substance Use And Addiction Treatment 2024, 164: 209392. PMID: 38735482, DOI: 10.1016/j.josat.2024.209392.Peer-Reviewed Original ResearchInjection drug useSubstance use disordersInternational Classification of DiseasesIncreased riskICD-10 codesDrug useClassification of diseasesHealthcare utilizationHealth servicesIncreased risk of overdoseFinancial reimbursementInternational ClassificationHealthcare systemRisk of overdoseTreatment servicesICD codesIdentifying peopleWell-beingPWIDUse disorderSystem of resource allocationHealthRiskImproved systemPotential benefitsA simple heuristic for allocating opioid settlement funding to reduce overdose mortality in the United States
Skinner A, Nolen S, Cerdá M, Rich J, Marshall B. A simple heuristic for allocating opioid settlement funding to reduce overdose mortality in the United States. The American Journal Of Drug And Alcohol Abuse 2024, 50: 269-275. PMID: 38940829, PMCID: PMC11305910, DOI: 10.1080/00952990.2024.2364338.Peer-Reviewed Original ResearchPublic health interventionsHealth interventionsOverdose mortalitySettlement fundsEvaluate public health interventionsOverdose crisisAverage probability of deathOverdose deathsDrug-related mortalityReduce overdose deathsReduce overdose mortalityAnnual numberProbability of deathRisk of overdoseAverage annual numberOverdose eventsUnited StatesFunding prioritiesInterventionMortalityOverdoseLocal governmentsRiskDeathStructural forces“They make it too hard and too many hoops to jump”: system and organizational barriers to drug treatment during epidemic rates of opioid overdose
Dickson-Gomez J, Krechel S, Ohlrich J, Montaque H, Weeks M, Li J, Havens J, Spector A. “They make it too hard and too many hoops to jump”: system and organizational barriers to drug treatment during epidemic rates of opioid overdose. Harm Reduction Journal 2024, 21: 52. PMID: 38413972, PMCID: PMC10900746, DOI: 10.1186/s12954-024-00964-5.Peer-Reviewed Original ResearchConceptsOpioid use disorderDrug treatmentImprove treatment retentionTreat opioid use disorderAttended group treatmentOpioid overdoseMedically managed withdrawalHeightened risk of overdoseRates of opioid overdoseCourse of treatmentTreatment retentionGroup treatmentUse disorderRisk of overdoseTreatment participationAbstinence requirementRespiratory depressionManaged withdrawalOpioidInitiate MOUDMOUD initiationMOUD stigmaMOUD treatmentHeightened riskOpioid overdose crisis
2023
Safe Opioid Prescribing and Controlled Substance Policies
Tobin D, Barrette E. Safe Opioid Prescribing and Controlled Substance Policies. 2023, 233-254. DOI: 10.1007/978-3-031-40273-9_16.Peer-Reviewed Original ResearchOpioid prescribingPrimary care physiciansResident continuity clinicProperties of opioidsContinuity clinicCare physiciansRisk of overdoseClinical directorsOpioidIndividual patientsPotential harmAdverse effectsPrescribingPatientsClinicPotential benefitsRegulatory landscapeRiskPotential riskAnalgesicPhysicians
2022
Population‐level impact of initiating pharmacotherapy and linking to care people with opioid use disorder at inpatient medically managed withdrawal programs: an effectiveness and cost‐effectiveness analysis
Savinkina A, Madushani RWMA, Yazdi G, Wang J, Barocas JA, Morgan JR, Assoumou SA, Walley AY, Linas BP, Murphy SM. Population‐level impact of initiating pharmacotherapy and linking to care people with opioid use disorder at inpatient medically managed withdrawal programs: an effectiveness and cost‐effectiveness analysis. Addiction 2022, 117: 2450-2461. PMID: 35315162, PMCID: PMC9377514, DOI: 10.1111/add.15879.Peer-Reviewed Original ResearchConceptsIncremental cost-effectiveness ratioOpioid use disorderStandard of careUse disordersFatal overdosesDetox patientsMOUD initiationWithdrawal programInitiation of medicationHealth care sector perspectiveRisk of overdoseFatal opioid overdosesCost-effectiveness ratioCost-effectiveness analysisOpioid useHealth care spendingOutpatient careDetox programsOpioid overdosesMOUDPatientsOverdosesPopulation-level impactDisorder populationHealth effectsRecovery Coaching In and Out of Emergency Departments: an Overview of the Connecticut Community for Addiction Recovery’s (CCAR) Emergency Department Recovery Coaching Program
Stanojlović M, Allen R, Valentine P, Davidson L, O’Connell M. Recovery Coaching In and Out of Emergency Departments: an Overview of the Connecticut Community for Addiction Recovery’s (CCAR) Emergency Department Recovery Coaching Program. International Journal Of Mental Health And Addiction 2022, 21: 3033-3042. DOI: 10.1007/s11469-022-00772-7.Peer-Reviewed Original ResearchRecovery coachesCoaching programED staff educationRecovery coaching servicesFollow-up careAddiction recoveryProfessional support networksConnecticut communitiesStaff educationIncreased risk of overdoseSubstance use disordersAppropriate careRisk of overdoseCoaching servicesEmergency departmentSupport networksReal-world settingsBuy-inInvestment of resourcesIncreased riskRelationship buildingCoachingUse disorderCareFinancial compensationBenzodiazepines and Related Sedatives
Peng L, Morford KL, Levander XA. Benzodiazepines and Related Sedatives. 2022, 106: 113-129. PMID: 34823725, DOI: 10.1016/j.mcna.2021.08.012.ChaptersConceptsLong-term benzodiazepine useQuality of evidenceRisk of overdoseSignificant adverse effectsCognitive behavioral therapySedative useBenzodiazepine useBenzodiazepine discontinuationPharmacologic propertiesBenzodiazepine taperWithdrawal managementPhysical dependenceBehavioral treatmentBehavioral therapyBenzodiazepinesDetoxification facilityNovel psychoactive substancesAdverse effectsDesigner benzodiazepinesPsychoactive substancesMost benefitDiscontinuationMedicationsSedativesOverdose
2021
Simulating the impact of Addiction Consult Services in the context of drug supply contamination, hospitalizations, and drug-related mortality
King C, Cook R, Wheelock H, Korthuis P, Leahy J, Goff A, Morris C, Englander H. Simulating the impact of Addiction Consult Services in the context of drug supply contamination, hospitalizations, and drug-related mortality. International Journal Of Drug Policy 2021, 100: 103525. PMID: 34837879, PMCID: PMC8810590, DOI: 10.1016/j.drugpo.2021.103525.Peer-Reviewed Original ResearchConceptsAddiction consult serviceOpioid use disorderDrug-related deathsConsult serviceHospital dischargeCare systemDrug-related causesOpioid-related deathsDrug supplyRisk of overdoseDrug-related mortalityOpioid overdose deathsHarm reduction interventionsAdult patientsOUD patientsHospital admissionOpioid overdosesEffective treatmentOverdose deathsSimulated cohortPatientsUse disordersReduction interventionsHospitalizationDeath
2020
Co-occurring opioid and sedative use disorder: Gender differences in use patterns and psychiatric co-morbidities in the United States
Ellis JD, Pittman BP, McKee SA. Co-occurring opioid and sedative use disorder: Gender differences in use patterns and psychiatric co-morbidities in the United States. Journal Of Substance Use And Addiction Treatment 2020, 114: 108012. PMID: 32527509, PMCID: PMC7292885, DOI: 10.1016/j.jsat.2020.108012.Peer-Reviewed Original ResearchConceptsSedative use disorderOpioid use disorderUse disordersCo-occurring opioid use disorderMeeting criteriaPsychiatric conditionsCurrent opioid use disorderCo-occurring opioidPersonality disorderRisk of overdoseLogistic regression analysisCo-occurring symptomsImplementation of treatmentPosttraumatic stress disorderSchizotypal personality disorderAntisocial personality disorderNon-medical useBaseline characteristicsDepressive disorderGender-stratified logistic regression analysesPrescription monitoringOwn prescriptionsOpioidsStress disorderNESARC-III
2019
Suspected heroin-related overdoses incidents in Cincinnati, Ohio: A spatiotemporal analysis
Li ZR, Xie E, Crawford FW, Warren JL, McConnell K, Copple JT, Johnson T, Gonsalves GS. Suspected heroin-related overdoses incidents in Cincinnati, Ohio: A spatiotemporal analysis. PLOS Medicine 2019, 16: e1002956. PMID: 31714940, PMCID: PMC6850525, DOI: 10.1371/journal.pmed.1002956.Peer-Reviewed Original ResearchConceptsRisk of overdoseRisk of incidentBlock groupHarm reduction measuresPoisson regression modelsHighest overdose ratesOpioid misuseRisk factorsOpioid epidemicOpiate overdosesOverdose incidentsOpioid overdosesOverdose ratesNature of incidentsEmergency callsMale populationMedian household incomeTreatment programOverdose emergencyHealth policySpatiotemporal risk factorsLack of informationDemographic characteristicsHigher numberOverdoses
2014
High prevalence of non-fatal overdose among people who inject drugs in Malaysia: Correlates of overdose and implications for overdose prevention from a cross-sectional study
Bazazi AR, Zelenev A, Fu JJ, Yee I, Kamarulzaman A, Altice FL. High prevalence of non-fatal overdose among people who inject drugs in Malaysia: Correlates of overdose and implications for overdose prevention from a cross-sectional study. International Journal Of Drug Policy 2014, 26: 675-681. PMID: 25532449, PMCID: PMC4452449, DOI: 10.1016/j.drugpo.2014.11.010.Peer-Reviewed Original ResearchConceptsNon-fatal overdoseRecent non-fatal overdoseRespondent-driven samplingDrug useOdds of overdoseOpioid substitution therapyInjection drug useMultivariable logistic regressionCross-sectional studyProvision of naloxoneRisk of overdoseCause of deathSelf-reported historyPast-month drug useMethadone usePrimary outcomePeriod prevalenceOpioid dependenceSubstitution therapyOpioid usersFatal overdoseHigh prevalenceLower oddsOverdose preventionPolysubstance use
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