Parsing the antidepressant effects of non-invasive brain stimulation and pharmacotherapy: A symptom clustering approach on ELECT-TDCS
Goerigk S, Padberg F, Chekroud A, Kambeitz J, Bühner M, Brunoni A. Parsing the antidepressant effects of non-invasive brain stimulation and pharmacotherapy: A symptom clustering approach on ELECT-TDCS. Brain Stimulation 2021, 14: 906-912. PMID: 34048940, DOI: 10.1016/j.brs.2021.05.008.Peer-Reviewed Original ResearchConceptsTranscranial direct current stimulationNon-invasive brain stimulationDepressive symptomsBrain stimulationEfficacy of tDCSCore depressive symptomsLinear mixed regression modelsDepressive symptom clustersConsiderable inter-individual variabilityDirect current stimulationEscitalopram 20Antidepressant effectsAntidepressant efficacyInter-individual variabilityAtypical symptomsDepressed patientsMixed regression modelsInsomnia symptomsTDCS sessionsPharmacotherapyEscitalopramSymptomsPlaceboSymptom clustersCurrent stimulationEfficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: a randomized, sham-controlled trial
Silva R, Brunoni A, Goerigk S, Batistuzzo M, Costa D, Diniz J, Padberg F, D’Urso G, Miguel E, Shavitt R. Efficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: a randomized, sham-controlled trial. Neuropsychopharmacology 2021, 46: 1028-1034. PMID: 33452434, PMCID: PMC8115679, DOI: 10.1038/s41386-020-00928-w.Peer-Reviewed Original ResearchConceptsTreatment-resistant obsessive-compulsive disorderTranscranial direct current stimulationSupplementary motor areaBaseline Y-BOCS scoresActive transcranial direct current stimulationObsessive-compulsive disorderY-BOCS scoresDirect current stimulationAdverse eventsWeek 12Efficacy of tDCSCurrent stimulationCathodal transcranial direct current stimulationSham-controlled trialMild adverse eventsClinical Global ImpressionSham-controlled studyBetween-group differencesSymptoms of depressionSecondary outcomesPrimary outcomeImprovement subscaleGlobal ImpressionNeuromodulation therapiesTreatment resistance
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