2021
Minocycline attenuates oxycodone-induced positive subjective responses in non-dependent, recreational opioid users
Mogali S, Askalsky P, Madera G, Jones JD, Comer SD. Minocycline attenuates oxycodone-induced positive subjective responses in non-dependent, recreational opioid users. Pharmacology Biochemistry And Behavior 2021, 209: 173241. PMID: 34298029, PMCID: PMC8429209, DOI: 10.1016/j.pbb.2021.173241.Peer-Reviewed Original ResearchConceptsAnalgesic effectRecreational opioid usersReceptor-selective agonistOpioid usersPreclinical studiesAbuse liabilityNew York State Psychiatric InstituteRelease of cytokinesPositive subjective effectsTetracycline antibiotic minocyclineYears of ageDouble-blind outpatient studyPositive subjective responsesGlial activationAcute administrationCertain medicationsHuman research volunteersOutpatient studyGlial cellsNon-treatment seekingSame dosesRewarding effectsOxycodoneDrug AdministrationMinocycline
2020
Differential effects of nicotine delivery rate on subjective drug effects, urges to smoke, heart rate and blood pressure in tobacco smokers
Jensen KP, Valentine G, Gueorguieva R, Sofuoglu M. Differential effects of nicotine delivery rate on subjective drug effects, urges to smoke, heart rate and blood pressure in tobacco smokers. Psychopharmacology 2020, 237: 1359-1369. PMID: 31996940, PMCID: PMC7386792, DOI: 10.1007/s00213-020-05463-6.Peer-Reviewed Original ResearchConceptsSubjective drug effectsBlood pressureHeart rateDrug effectsSmoking urgesDifferential effectsBlood pressure increaseBody weight doseEffects of nicotineDelivery rateGreater heart rateAmount of nicotineWeight doseFemale smokersTobacco smokersAbstinence symptomsNicotine doseSaline infusionInfusion protocolNon-treatment seekingTobacco cigarettesHuman studiesInfusionTobacco productsNicotine
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