2023
Assessing Clinical Utility of Pharmacogenetic Testing in the Military Health System
Hellwig L, Turner C, Olsen C, Libbus J, Markos B, Koehlmoos T, Haigney M, De Castro M, Saunders D. Assessing Clinical Utility of Pharmacogenetic Testing in the Military Health System. Military Medicine 2023, 189: e198-e204. PMID: 37436924, PMCID: PMC11022329, DOI: 10.1093/milmed/usad254.Peer-Reviewed Original ResearchMilitary Health SystemPharmacogenetic testingAdverse eventsCPIC guidelinesPGx testingHealth systemCurrent medication regimensPreemptive PGx testingPrimary care clinicsPreventable adverse eventsAdverse drug reactionsLarge military treatment facilitySubstantial proportionCross-sectional studyMilitary treatment facilitiesMedication metabolismPGx implementationMedication regimensRisk medicationsSerious morbidityCare clinicsMedical managementMedication listPGx resultsSingle center
2022
Characterization of Laryngotracheal Fractures and Repairs: A TQIP Study
Bourdillon A, Kafle S, Salehi P, Steren B, Pei K, Azizzadeh B, Lee Y. Characterization of Laryngotracheal Fractures and Repairs: A TQIP Study. Journal Of Voice 2022, 38: 1450-1457. PMID: 35817623, DOI: 10.1016/j.jvoice.2022.06.007.Peer-Reviewed Original ResearchLaryngeal fracture repairMedian lengthCut/pierce injuriesMedian Injury Severity ScoreFracture repairInjury Severity ScoreMultivariate logistic regressionCause of injuryHigher ISS scoresChi-squared analysisACS TQIPHospital stayICU stayLaryngotracheal injuriesSerious morbidityBlunt traumaDisease 9Laryngotracheal traumaProcedure characteristicsISS scoreSeverity scoreAmerican CollegeInternational ClassificationStudy settingInjury
2019
Does Perceived Resident Operative Autonomy Impact Patient Outcomes?
Fieber JH, Bailey EA, Wirtalla C, Johnson AP, Leeds IL, Medbery RL, Ahuja V, VanderMeer T, Wick EC, Irojah B, Kelz RR. Does Perceived Resident Operative Autonomy Impact Patient Outcomes? Journal Of Surgical Education 2019, 76: e182-e188. PMID: 31377204, DOI: 10.1016/j.jsurg.2019.06.006.Peer-Reviewed Original ResearchConceptsGeneral surgery training programsColorectal resectionSurgery serviceSurgery training programsPatient outcomesTrainee autonomyProspective multi-institutional studyColorectal surgery serviceOpen partial colectomyPrior abdominal surgeryRate of readmissionPatients' clinical outcomesPost-graduate year 3Multi-institutional studyImpact patient outcomesMixed effects regression modelsLower ratesAnesthesiologists classificationSeparate mixed-effects regression modelsColorectal surgeryPrimary outcomeSecondary outcomesAbdominal surgerySerious morbidityClinical outcomes
2018
Racial disparities in surgical outcomes of patients with Inflammatory Bowel Disease
Montgomery SR, Butler PD, Wirtalla CJ, Collier KT, Hoffman RL, Aarons CB, Damrauer SM, Kelz RR. Racial disparities in surgical outcomes of patients with Inflammatory Bowel Disease. The American Journal Of Surgery 2018, 215: 1046-1050. PMID: 29803499, PMCID: PMC7764563, DOI: 10.1016/j.amjsurg.2018.05.011.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseBlack patientsBowel diseaseSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramMultivariable logistic regression modelingSurgical Quality Improvement ProgramRetrospective cohort studyTraditional risk factorsLogistic regression modelingQuality Improvement ProgramASA classIBD patientsEmergent surgeryCohort studySerious morbidityWhite patientsStoma creationSurgical outcomesHealth disparities researchRisk factorsAmerican CollegePatientsSurgeryRacial disparitiesReassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity
Grantz KL, Sundaram R, Ma L, Hinkle S, Berghella V, Hoffman MK, Reddy UM. Reassessing the Duration of the Second Stage of Labor in Relation to Maternal and Neonatal Morbidity. Obstetrics And Gynecology 2018, 131: 345-353. PMID: 29324600, PMCID: PMC5785437, DOI: 10.1097/aog.0000000000002431.Peer-Reviewed Original ResearchConceptsSpontaneous vaginal birthSecond stage durationVaginal birthNulliparous womenNeonatal complicationsNeonatal morbidityCesarean deliveryFetal heart rate tracingsFirst half hourPrior cesarean deliverySpontaneous vaginal deliveryWeeks of gestationHeart rate tracingsVertex birthsRetrospective cohortMultiparous womenSerious complicationsSerious morbidityVaginal deliveryMorbidityHalf hourLikelihood of birthComplicationsWomenBirth
2017
Obesity and its implications for morbidity and mortality after cholecystectomy: A matched NSQIP analysis
Augustin T, Moslim M, Brethauer S, Aminian A, Kroh M, Schneider E, Walsh R. Obesity and its implications for morbidity and mortality after cholecystectomy: A matched NSQIP analysis. The American Journal Of Surgery 2017, 213: 539-543. PMID: 28237044, DOI: 10.1016/j.amjsurg.2016.11.037.Peer-Reviewed Original ResearchConceptsAcute cholecystitisClavien 4 complicationsSO patientsNSQIP AnalysisSuper obesityOpen surgeryNon-obese patientsObese patientsSerious morbidityLaparoscopic surgeryCholecystectomyPatientsSurgeryMorbidityComplicationsObesityChronicMortalityAggressive recommendationsRiskCholecystitisComorbidities
2016
Influence of Specialty Training and Trainee Involvement on Perioperative Outcomes of Esophagectomy
Khoushhal Z, Canner J, Schneider E, Stem M, Haut E, Mungo B, Lidor A, Molena D. Influence of Specialty Training and Trainee Involvement on Perioperative Outcomes of Esophagectomy. The Annals Of Thoracic Surgery 2016, 102: 1829-1836. PMID: 27570158, DOI: 10.1016/j.athoracsur.2016.06.025.Peer-Reviewed Original ResearchConceptsVolume-outcome relationshipGeneral surgeonsHospital stayCardiothoracic surgeonsTrainee involvementTransthoracic approachNational Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseQuality Improvement Program databaseOutcomes of esophagectomyImprovement Program databaseLonger hospital stayShorter hospital staySurgeon volume-outcome relationshipUnplanned intubationOverall morbidityPerioperative outcomesPostoperative outcomesSecondary outcomesDischarge destinationPrimary outcomeSerious morbidityCTS patientsSurgeon specialtyWound infection
2015
Management of chemotherapy-induced neutropenia: measuring quality, cost, and value.
Dinan MA, Hirsch BR, Lyman GH. Management of chemotherapy-induced neutropenia: measuring quality, cost, and value. Journal Of The National Comprehensive Cancer Network 2015, 13: e1-7. PMID: 25583775, DOI: 10.6004/jnccn.2015.0014.Peer-Reviewed Original ResearchConceptsFebrile neutropeniaHigh riskNCCN Clinical Practice GuidelinesBroad-spectrum antibiotic treatmentCommon dose-limiting toxicityChemotherapy dose reductionsConsideration of prophylaxisLow-risk regimensDose-limiting toxicityChemotherapy-induced neutropeniaClinical practice guidelinesHealth care useEpisode of careMyeloid growth factorsGrowth factor useEarly treatment terminationHealth care costsPrimary prophylaxisMyelosuppressive chemotherapySupportive careSerious morbidityTreatment delayTherapeutic optionsAntibiotic treatmentCare use
2014
Impact of requiring influenza vaccination for children in licensed child care or preschool programs--Connecticut, 2012-13 influenza season.
Hadler JL, Yousey-Hindes K, Kudish K, Kennedy ED, Sacco V, Cartter ML. Impact of requiring influenza vaccination for children in licensed child care or preschool programs--Connecticut, 2012-13 influenza season. MMWR Morbidity And Mortality Weekly Report 2014, 63: 181-5. PMID: 24598593, PMCID: PMC4584725.Peer-Reviewed Original ResearchConceptsInfluenza-associated hospitalization ratesEmerging Infections ProgramInfluenza seasonHospitalization ratesVaccination ratesInfluenza transmissionSevere influenza-related illnessInfluenza-related illnessInfluenza-associated hospitalizationsLicensed child care programsOverall population rateGreater percentage decreaseCare admissionInfluenza vaccinationInfluenza vaccineSerious morbiditySusceptible childrenVaccination levelsInfections ProgramVaccination dataCare settingsEIP sitesCare programConnecticut childrenSurveillance sites
2004
Allelic and haplotypic association of GABRA2 with alcohol dependence
Covault J, Gelernter J, Hesselbrock V, Nellissery M, Kranzler HR. Allelic and haplotypic association of GABRA2 with alcohol dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2004, 129B: 104-109. PMID: 15274050, DOI: 10.1002/ajmg.b.30091.Peer-Reviewed Original ResearchConceptsAlcohol-dependent subjectsAlcohol dependenceSingle nucleotide polymorphismsMajor depressive episodeGABAA receptor subunitsSubstance use disordersHaplotypic associationsEvidence of associationSerious morbidityOpioid dependenceAlpha 2 subunitDepressive episodePrevalent disorderUse disordersEuropean-American subjectsNeurotransmitter receptorsControl groupDrug dependenceReceptor subunitsCommon haplotypeGABRA2 geneBehavioral effectsImportant mediatorAssociationSubjectsFetal Infants: The Fate of 4172 Infants With Birth Weights of 401 to 500 Grams—The Vermont Oxford Network Experience (1996–2000)
Lucey J, Rowan C, Shiono P, Wilkinson A, Kilpatrick S, Payne N, Horbar J, Carpenter J, Rogowski J, Soll R. Fetal Infants: The Fate of 4172 Infants With Birth Weights of 401 to 500 Grams—The Vermont Oxford Network Experience (1996–2000). 2004, 113: 1559-1566. PMID: 15173474, DOI: 10.1542/peds.113.6.1559.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitDelivery roomGestational ageVermont Oxford Network databaseLow birth weight infantsBirth weight 401Birth weight infantsIntensive care unitLong-term outcomesPopulation of infantsImpact of treatmentNICU admissionNICU survivorsWeight infantsCesarean sectionSerious morbidityCare unitPrenatal steroidsSignificant morbidityBirth weightClinical dataHigh incidenceInfantsMorbidityHigh rate
2003
Falls
Thomas D, Edelberg H, Tinetti M. Falls. 2003, 979-994. DOI: 10.1007/0-387-22621-4_67.Peer-Reviewed Original ResearchFall prevention programMajority of fallsRisk of fallsNursing home residentsSingle disease processConsiderable morbiditySerious morbidityExercise programRisk factorsHome residentsParkinson's diseaseDisease processActivity restrictionPrevention programsOlder individualsCareful assessmentSerious injuriesCommon eventMorbidityFallersRiskInjuryDiseaseIntrinsic eventsRecent studies
2002
Endoscopic vein harvest: early results of a prospective trial with open vein harvest.
Bonde P, Graham A, MacGowan S. Endoscopic vein harvest: early results of a prospective trial with open vein harvest. The Heart Surgery Forum 2002, 5 Suppl 4: s378-91. PMID: 12759210.Peer-Reviewed Original ResearchConceptsEndoscopic vein harvestSaphenous vein harvestVein harvestOperative timeEVH groupPostoperative painWound painVein qualityFisher s exact testLeg wound infectionsOpen vein harvestPost-operative painOverall operative timeGreater patient satisfactionWound healingExtended treatment periodMann-Whitney UEarly ambulationProspective trialASEPSIS scoreSerious morbidityOVH groupWound infectionPatient satisfactionTreatment period
1997
Recurrent Angiotensin-Converting Enzyme Inhibitor—Associated Angioedema
Brown N, Snowden M, Griffin M. Recurrent Angiotensin-Converting Enzyme Inhibitor—Associated Angioedema. JAMA 1997, 278: 232-233. DOI: 10.1001/jama.1997.03550030072037.Peer-Reviewed Original ResearchConceptsACE inhibitor useAngiotensin converting enzyme (ACE) inhibitorsACE inhibitorsInhibitor useRecurrent angioedemaEnzyme inhibitorsEpisodes of angioedemaRate of angioedemaRetrospective cohort studyDiagnosis of angioedemaRisk of angioedemaTennessee Medicaid programAngioedema recurrencesCohort studySerious morbidityRecurrent episodesMedical recordsAssociated angioedemaMultiple recurrencesMedicaid enrolleesAngioedemaPatientsRecurrenceNumber of causesMedicaid programRecurrent angiotensin-converting enzyme inhibitor--associated angioedema.
Brown N, Snowden M, Griffin M. Recurrent angiotensin-converting enzyme inhibitor--associated angioedema. JAMA 1997, 278: 232-3. PMID: 9218671, DOI: 10.1001/jama.278.3.232.Peer-Reviewed Original ResearchConceptsACE inhibitor useACE inhibitorsInhibitor useRecurrent angioedemaEnzyme inhibitorsAngiotensin-converting enzyme inhibitorEpisodes of angioedemaRate of angioedemaRetrospective cohort studyDiagnosis of angioedemaRisk of angioedemaTennessee Medicaid programAngioedema recurrencesCohort studySerious morbidityRecurrent episodesMedical recordsAssociated angioedemaMultiple recurrencesMedicaid enrolleesAngioedemaPatientsRecurrenceNumber of causesMedicaid program
1994
A Multifactorial Intervention to Reduce the Risk of Falling among Elderly People Living in the Community
Tinetti M, Baker D, McAvay G, Claus E, Garrett P, Gottschalk M, Koch M, Trainor K, Horwitz R. A Multifactorial Intervention to Reduce the Risk of Falling among Elderly People Living in the Community. New England Journal Of Medicine 1994, 331: 821-827. PMID: 8078528, DOI: 10.1056/nejm199409293311301.Peer-Reviewed Original ResearchConceptsRisk factorsIntervention groupControl groupPrescription medicationsAdjusted incidence rate ratioTargeted risk factorsUsual health careElderly peopleRisk factor modificationIncidence rate ratiosUse of sedativesTime of reassessmentYears of ageParticular risk factorsRange of motionProportion of personsPostural hypotensionMultifactorial interventionSerious morbidityExercise programGait impairmentBalance impairmentLeg strengthElderly personsMedications
1992
Special health considerations for travelers
Bia F, Barry M. Special health considerations for travelers. 1992, 76: 1295-1312. PMID: 1405820, DOI: 10.1016/s0025-7125(16)30288-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAvailable antimalarial agentsLevel of immunosuppressionTime of immunizationBlood gas determinationsInsulin dosage adjustmentsChronic enteric infectionHealth considerationsDiabetic travelersCardiac eventsPulmonary functionPulmonary diseaseSerious morbidityDosage adjustmentAdult travelersEnteric infectionsPediatric usePhysiologic responsesHealth problemsGas determinationsAntimalarial agentsYoung childrenTravel kitCabin pressureSpecial precautionsImmunosuppression
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