Professor of Radiology and Biomedical Imaging and of Biomedical Engineering; Co-Director MRI Research Center, Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Credit: Robert A. Lisak
Ever since the discovery of Magnetic Resonance Imaging (MRI), the field of MR has diverged into MRI and Magnetic Resonance Spectroscopy (MRS). Whereas MRI typically observes a water signal, MRS detects all chemicals above a minimum concentration threshold. The members of the Yale MRS group have been pioneers in many of the applications of MRS to the study of metabolism in vivo. The detection of glycogen has been a breakthrough in the non-invasive study of liver and muscle function. The development of 13C MRS methods to study dynamic metabolic fluxes provides unique insights into metabolism that can not be obtained by any other technique. Combining MRS methods with other modalities, like electrophysiology, enhances the understanding of the relation between metabolism and function. And while the current applications of MRS are already many and diverse, the future holds even more promise with the exploration of other nuclei and improved hardware.
About Us
TAC machine
The Yale Magnetic Resonance Spectroscopy (MRS) group was founded in 1986 under the leadership of Robert Shulman. Recognizing the potential of MRS to study metabolism and function non-invasively in vivo, the group quickly evolved the MRS studies from cells to animals and ultimately to humans. Among the numerous contributions of the Yale group to the field of in vivo MRS are the development of 13C MR methods to study metabolic fluxes in vivo, the use of multi-modal MR methods to study brain function, and the implementation of sophisticated hardware to address specific MRS problems. Under the leadership of Douglas Rothman, the MRS group has expanded to a large roster of several faculty, staff and postdoctoral associates and students, using three animal (4, 9.4 and 11.7 T) and two human (4 and 7 T) MR systems.
Research
The research performed in the Yale MRS group is as diverse as its faculty. The long and rich history of the Yale MRS group with the study of metabolism using heteronuclear (13C, 15N, 31P) MRS techniques still remains a prime focus point today. Among the many collaborations, 13C MRS is applied to study metabolism in diabetes (Douglas Rothman) and psychiatric disorders (Graeme Mason). Fahmeed Hyder is studying cerebral metabolism in relation to neuronal activity and function with a wide range of techniques, whereas Kevin Behar is studying cerebral metabolism under a variety of conditions, like hypoxia. The research of Robin de Graaf focuses on the further development of MR methods and hardware to enhance the MRS information content and reliability.
Current Projects
Dr. Robin deGraaf’s current research encompasses three primary areas. Central to the technological innovation of this research is the development of methods to achieve magnetic field uniformity throughout the human and animal brain. The problem of magnetic field inhomogeneity is tackled through dynamic shimming and the use of electrical coil and passive shim element arrays. Methods for 13C NMR have been pioneered at YSM, and part of the research involves extending these methods to achieve 3D coverage, higher sensitivity (through 1H detection), and higher specificity (e.g., GABA turnover detection). Additionally, the field of 17O NMR appears promising for fast and sensitive mapping of various metabolic fluxes. This research includes the synthesis of 17O-labeled compounds, the development of novel 17O MR methods, and the in vivo detection of 17O label turnover.
Dr. Fahmeed Hyder's laboratory focuses on several specific ongoing research topics. These include high spatiotemporal resolution fMRI at ultra-high fields to study sensory columns at extremely high resolution, and investigating the electrophysiological basis of the BOLD signal by examining excitatory and inhibitory neural events underlying the response. Additionally, the lab explores the rheological basis of the BOLD signal, considering the contributions of blood plasma and erythrocytes on the BOLD response. The energetics of neuronal populations are studied through fMRI to understand subcortical mechanisms underlying cortical activations for unisensory and multisensory stimuli. Furthermore, the lab is involved in translating smart contrast agents for tumor characterization by MR, aiming to synthesize and translate agents for improved biosensing of pH and temperature.
Dr. Graeme Mason's research integrates quantitative approaches to measure functional brain chemistry and the study of neuropsychiatric disorders. The primary methods employed are 1H and 13C magnetic resonance spectroscopy and mathematical assessment of metabolism. Current research areas include depression, manic-depressive disorder, alcoholism, panic disorder, premenstrual syndrome, and post-partum depression. His primary interests lie in the effects of alcohol and nicotine dependence on the brain. Dr. Mason's research program evaluates both the acute and chronic effects of alcohol and nicotine on the brain, from perspectives of neurotransmission, metabolism, adaptation, and vulnerability to dependence.
Faculty & Researchers
Associate Professor of Radiology and Biomedical Imaging and of Biomedical Engineering
Research Interests- Brain Neoplasms
- Liver Neoplasms
- Molecular Imaging
Associate Professor of Radiology and Biomedical Imaging
Research Interests- Magnetic Resonance Spectroscopy
- Biomarkers, Tumor
- Metabolic Networks and Pathways
Professor of Radiology and Biomedical Imaging
Research Interests- Biomedical Engineering
- Energy Metabolism
- Magnetic Resonance Spectroscopy
- Radiology
Research Scientist in Radiology and Biomedical Imaging
Research Interests- Cerebrovascular Circulation
- Hematocrit
- Membrane Potentials
- Oxygen Consumption
- Fractals
Professor of Radiology and Biomedical Imaging and of Biomedical Engineering; Technical Director, Magnetic Resonance Research Center (mrrc.yale.edu); Program Director, Core Center for Quantitative Neuroscience with Magnetic Resonance (qnmr.yale.edu)
Research Interests- Biomedical Engineering
- Magnetic Resonance Imaging
- Neoplasms by Histologic Type
- Neurosciences
- Radiology
- Molecular Probes
Professor of Radiology and Biomedical Imaging and of Psychiatry; Director Metabolic Modeling and Director Psychiatric MRS, Magnetic Resonance Research Center; Director, Neuroimaging Sciences Training Program, Radiology & Biomedical Imaging and Psychiatry; Chair, Magnetic Resonance Research Center Protocol Review Committee, Radiology & Biomedical Imaging
Research Interests- Alcoholic Intoxication
- Alcoholism
- Amino Acids
- Carbohydrates
- Central Nervous System Diseases
- Fatty Acids
- Mathematical Computing
- Substance Withdrawal Syndrome
- Mood Disorders
- Alcohol-Induced Disorders, Nervous System
- Molecular Mechanisms of Pharmacological Action
- Physiological Effects of Drugs
- Neuroimaging
Assistant Professor of Radiology and Biomedical Imaging; Director, Small Animal MRI Core, Magnetic Resonance Research Center
Selected Publications
2025
Oral intake of deuterated choline at clinical dose for metabolic imaging of brain tumors
Osoliniec V, Thomas M, de Graaf R, De Feyter H. Oral intake of deuterated choline at clinical dose for metabolic imaging of brain tumors. Npj Imaging 2025, 3: 54. PMID: 41136682, PMCID: PMC12552732, DOI: 10.1038/s44303-025-00113-y.Peer-Reviewed Original ResearchIntravenous infusionMetabolic imagingOral intakeDeuterium metabolic imagingClinical doseMetabolic imaging of brain tumorsTumor-to-normal-brainOral administrationBrain tumorsClinical translationOral low dosesRat glioblastoma modelNoninvasive imaging toolBrain tumor characterizationIntravenous doseTumor metabolismTumor characterizationTumor tissuesImaging of brain tumorsGlioblastoma modelLow dosesTumorDoseAnatomical MRIImaging toolMulticenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP-Ribose) Polymerase Inhibitor Veliparib.
Koehler RC, Bedirian K, Chen MH, Shi Y, Cao S, Avery BD, Karuppagounder SS, Akhter K, Bibic A, Dawson VL, Dawson TM, Diniz MA, Lamb J, Nagarkatti KA, Chauhan A, Aronowski J, McCullough LD, de Morais AL, Jin X, Ayata C, Kumskova M, Patel RB, Chauhan AK, Leira EC, Kamat PK, Khan MB, Dhandapani KM, Hess DC, Boisserand LSB, Sanganahalli BG, Sansing LH, Lyden PD, SPAN investigators [Link]. Multicenter Stroke Preclinical Assessment Network Analysis of Cardiovascular Risk Factor Subgroups Treated With the Poly(ADP-Ribose) Polymerase Inhibitor Veliparib. J Am Heart Assoc 2025, 14: e040914. PMID: 40996065, DOI: 10.1161/JAHA.124.040914.Peer-Reviewed Original ResearchEmbracing Scientific Debate in Brain Metabolism
Andersen J, Aldana B, Bak L, Behar K, Borges K, Carruthers A, Cumming P, Derouiche A, Díaz‐García C, Drew K, Duarte J, Ferreira G, Giove F, Gjedde A, Hyder F, Ioannou M, Kann O, Kristian T, Lai J, Mason G, McNay E, Nedergaard M, Nowak T, Patel A, Rae C, Ryan T, Schuck P, Simpson I, Vannucci S, Waagepetersen H, Yellen G, McKenna M. Embracing Scientific Debate in Brain Metabolism. Journal Of Neurochemistry 2025, 169: e70230. PMID: 40966093, DOI: 10.1111/jnc.70230.Peer-Reviewed Original ResearchMultivariate Pattern Analysis of Perfusion and Oxygenation Impairment in Asymptomatic Carotid Artery Stenosis
Kufer J, Preibisch C, Göttler J, Schmitzer L, Hoffmann G, Kallmayer M, Zimmer C, Hyder F, Kaczmarz S. Multivariate Pattern Analysis of Perfusion and Oxygenation Impairment in Asymptomatic Carotid Artery Stenosis. Journal Of Neuroimaging 2025, 35: e70084. PMID: 40947496, PMCID: PMC12434150, DOI: 10.1111/jon.70084.Peer-Reviewed Original ResearchConceptsInternal carotid artery stenosisInternal carotid artery stenosis patientsCerebral blood flowRelative oxygen extraction fractionCarotid artery stenosisHealthy controlsSSM-PCAHemodynamic impairmentArtery stenosisAsymptomatic internal carotid artery stenosisAsymptomatic carotid artery stenosisOxygen extraction capacityAnalysis of perfusionOxygen extraction fractionOxygenation impairmentICAS patientsDisease-related patternsHemodynamic imbalanceDisease-related alterationsTreatment decisionsInterhemispheric lateralizationBlood flowStroke riskPatientsMultivariate pattern analysisPreclinical Ischemic Stroke Multicenter (PRISM) Trials Collective Statement: Opportunities, Challenges, and Recommendations for a New Era.
Ayata C, Bath P, Planas A, Allan S, Boltze J, Cabeen R, Gibson C, Cipolla M, Diniz M, Fumagalli S, Hyder F, Koehler R, Liesz A, McCann S, Magnus T, McCullough L, Sena E, Beretta S, Aronowski J, Bosetti F, Wright C, Lyden P, Sansing L. Preclinical Ischemic Stroke Multicenter (PRISM) Trials Collective Statement: Opportunities, Challenges, and Recommendations for a New Era. Stroke 2025 PMID: 40931817, PMCID: PMC12455296, DOI: 10.1161/strokeaha.125.052056.Peer-Reviewed Original ResearchFingolimod as a Potential Cerebroprotectant Results From the Stroke Preclinical Assessment Network.
Boisserand L, Herman A, Sanganahalli B, Mihailovic J, Beatty H, Johnson C, Diaz S, DeLong J, Velazquez S, Grutzendler J, Dela Cruz C, Zhou J, Sheth K, Matouk C, Zhan S, Morais A, Imai T, Chauhan A, Patel R, Kumskova M, Shi Y, Avery B, Lamb J, Nagarkatti K, Khan M, Kamat P, Dhandapani K, McCullough L, Aronowski J, Hess D, Koehler R, Lyden P, Leira E, Chauhan A, Ayata C, Chen M, Diniz M, Hyder F, Sansing L. Fingolimod as a Potential Cerebroprotectant Results From the Stroke Preclinical Assessment Network. Stroke 2025 PMID: 40899256, DOI: 10.1161/strokeaha.125.050903.Peer-Reviewed Original ResearchSphingosine-1-phosphate receptorsComorbidity modelFunctional outcomesLesion sizeDay 7Therapeutic potentialEffects of fingolimodSecondary lymphoid organsYoung healthy miceClinically relevant modelMiddle cerebral artery occlusionPrimary functional outcomeBrain morphometrySpontaneously Hypertensive RatsCerebral artery occlusionCorner testSphingosine-1-PhosphateMagnetic resonance imagingHigh-fat dietFoot-fault testFingolimod effectsImmunomodulatory drugsLess atrophyHealthy miceFingolimodComment on the Editorial “Embracing the Modern Biochemistry of Brain Metabolism”
Dienel G, Rothman D, Mangia S. Comment on the Editorial “Embracing the Modern Biochemistry of Brain Metabolism”. Journal Of Neurochemistry 2025, 169: e70197. PMID: 40810250, PMCID: PMC12351431, DOI: 10.1111/jnc.70197.Peer-Reviewed Original Research[18F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury
Chen B, Zheng C, Balayeva T, Toyonaga T, Wang X, Tong J, Mennie W, Mihailovic J, Coman D, Hyder F, Strittmatter S, Carson R, Huang Y, Cai Z. [18F]SynVesT-1 PET Detects SV2A Changes in the Spinal Cord and Brain of Rats with Spinal Cord Injury. Journal Of Nuclear Medicine 2025, 66: 1440-1448. PMID: 40675757, PMCID: PMC12410297, DOI: 10.2967/jnumed.124.269291.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDistribution volume ratioDiffusion tensor imagingSpinal cordRat modelDay 1SUV ratioImmunohistochemical stainingSham controlsDay 9PET imagingRat model of spinal cord injuryContusion SCI rat modelSpinal cord injury ratsModel of spinal cord injuryCord injuryWestern blottingModerate contusion injuryBrain of ratsDiffusion tensor imaging analysisPost-mortem spinal cordTraumatic spinal cord injurySCI rat modelSynaptic vesicle glycoprotein 2ACervical cordKetosis elevates antioxidants and markers of energy metabolism: A 1H MR spectroscopy study
van Nieuwenhuizen H, Antal B, Hone-Blanchet A, Lithen A, McMahon L, Nikolaidou S, Kuang Z, Clarke K, Jenkins B, Rothman D, Mujica-Parodi L, Ratai E. Ketosis elevates antioxidants and markers of energy metabolism: A 1H MR spectroscopy study. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40633732, DOI: 10.1016/j.bpsc.2025.06.009.Peer-Reviewed Original ResearchNeurochemical effectsNeural functionDevelopment of novel treatment strategiesProton magnetic resonance spectroscopyNovel treatment strategiesRs-fMRIGamma-aminobutyric acidMR spectroscopy studiesNeuroactive amino acidsMagnetic resonance imagingEnergy markersH-MRSAcute ketosisKetone monoesterTreatment strategiesBrain metabolitesResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingTotal creatineMarkers of energy metabolismRs-fMRI scansFunctional neuroimaging findingsGlucose drinkPosterior cingulate cortexGlutamine levelsMapping of neurovascular and neurometabolic couplings by multimodal optical imaging
Herman P, Sanggaard S, James S, Akif A, Mishra S, Sanganahalli B, Verhagen J, Blumenfeld H, Hyder F. Mapping of neurovascular and neurometabolic couplings by multimodal optical imaging. Cerebral Cortex 2025, 35: bhaf165. PMID: 40624899, DOI: 10.1093/cercor/bhaf165.Peer-Reviewed Original ResearchConceptsCerebral blood volumeNeuronal activityNeurometabolic couplingAlterations of neuronal activityNeurovascular couplingImaging of metabolic activityCerebral blood volume changesBolus injectionGlucose uptakeMultimodal optical imagingBlood volumeCalcium indicatorNear-infrared spectroscopyOptical imagingSimultaneous imagingBlood volume changesNear-infrared spectroscopy recordingsTraumatic brain injuryBrain injuryMultiplexed optical imagingGlucose analogMetabolic activityGECIsOptical systemCa21727-P: Reduced Aromatic Amino Acid Suppression during Acute Hyperglycemia in Young Adults with Obesity
MATSON B, GUNAWAN F, ROTHMAN D, MASON G, NEWGARD C, HWANG J. 1727-P: Reduced Aromatic Amino Acid Suppression during Acute Hyperglycemia in Young Adults with Obesity. Diabetes 2025, 74 DOI: 10.2337/db25-1727-p.Peer-Reviewed Original ResearchCentral nervous systemAcute hyperglycemiaLean controlsBrain glucose levelsMass spectrometry-based metabolomic profilingMeasured plasma amino acidsInsulin resistanceGlucose levelsBranched chain amino acidsPlasma amino acidsDevelopment of insulin resistanceAromatic amino acid levelsChain amino acidsAcid suppressionResponse to hyperglycemiaMetabolomic profilesImpaired suppressionHyperglycemic clampObesityInsulin sensitivityHyperglycemiaNervous systemAmino acid changesBrain glucoseHealthy adults358-OR: Acute Fatty Acid Elevation Does Not Alter Brain Glucose Uptake in Humans
MATSON B, CHANG W, PALMIOTTO J, ROTHMAN D, BELFORT DE AGUIAR R, MASON G, HWANG J. 358-OR: Acute Fatty Acid Elevation Does Not Alter Brain Glucose Uptake in Humans. Diabetes 2025, 74 DOI: 10.2337/db25-358-or.Peer-Reviewed Original ResearchElevation of non-esterified fatty acidsNon-esterified fatty acid levelsHyperglycemic clampBrain glucose uptakeCirculating non-esterified fatty acidsBrain glucoseAcute elevationIntralipid infusionInsulin resistanceIntravenous infusion of salineAbsence of insulin resistanceNon-esterified fatty acidsInduce peripheral insulin resistanceHealthy adultsInfusion of salinePresence of hyperglycemiaGlucose uptakeMeasures of insulin sensitivityPeripheral insulin resistanceHigh-fat dietGlucose infusion rateIntravenous infusionPlasma glucoseLean individualsMRS scansA Bird's‐Eye View of Glycolytic Upregulation in Activated Brain: The Major Fate of Lactate Is Release From Activated Tissue, Not Shuttling to Nearby Neurons
Dienel G, Rothman D, Mangia S. A Bird's‐Eye View of Glycolytic Upregulation in Activated Brain: The Major Fate of Lactate Is Release From Activated Tissue, Not Shuttling to Nearby Neurons. Journal Of Neurochemistry 2025, 169: e70111. PMID: 40476345, PMCID: PMC12142580, DOI: 10.1111/jnc.70111.Peer-Reviewed Original ResearchConceptsNeuron-astrocyte interactionsCerebral blood flowMetabolic brain imagingMetabolite of glucoseMetabolic mismatchBlood-borne glucoseActive neuronsAdequate oxygenationNearby neuronsActive tissuesLactate transportBlood flowAerobic glycolysisGlycolytic metabolismIntense sensory stimulationAstrocytesNeuronsTissue pHBrain cellsAstrocytic glycogenBrainSensory stimulationTissueGlycolysisRate of glucoseCysteine depletion triggers adipose tissue thermogenesis and weight loss
Lee A, Orliaguet L, Youm Y, Maeda R, Dlugos T, Lei Y, Coman D, Shchukina I, Andhey P, Smith S, Ravussin E, Stadler K, Chen B, Artyomov M, Hyder F, Horvath T, Schneeberger M, Sugiura Y, Dixit V. Cysteine depletion triggers adipose tissue thermogenesis and weight loss. Nature Metabolism 2025, 7: 1204-1222. PMID: 40461845, PMCID: PMC12198010, DOI: 10.1038/s42255-025-01297-8.Peer-Reviewed Original ResearchConceptsWeight lossWhite adipose tissueAdipose browningCaloric restrictionAdipose tissueDietary amino acidsCysteine depletionSulphur amino acids cysteineIncreased energy expenditureAdipose tissue thermogenesisIncreased fat utilizationMetabolic inflammationNoradrenaline signalingOrganismal metabolismAdipose thermogenesisObese miceBrowning of adipocytesIncreased heat productionBrownRemoval of cysteineCore body temperatureAmino acidsEnergy expenditureAmino acid cysteineFat utilizationMulticenter SPAN Trial of Fasudil in Ischemic Stroke
Imai T, de Morais A, Jin X, Qin T, Lamb J, Nagarkatti K, Chen M, Boisserand L, Patel R, Kumskova M, Chauhan A, Dhandapani K, Khan M, Kamat P, Shi Y, Cao S, Sanganahalli B, Mandeville J, Lyden P, Hess D, Leira E, Chauhan A, Aronowski J, McCullough L, Koehler R, Sansing L, Diniz M, Ayata C, Investigators O. Multicenter SPAN Trial of Fasudil in Ischemic Stroke. Stroke 2025, 56: 2306-2317. PMID: 40421536, PMCID: PMC12407252, DOI: 10.1161/strokeaha.125.050977.Peer-Reviewed Original ResearchSpontaneously Hypertensive RatsRho-associated kinase inhibitorHypertensive ratsAged miceActive treatment armsIschemic strokeModified intention-to-treat cohortKinase inhibitorsPrimary outcome end pointsIntention-to-treat cohortTest performanceEfficacy of fasudilPer-protocol populationOutcome end pointsMiddle cerebral artery occlusion modelHealthy young miceDiet-induced obese miceRodent modelsTrials NetworkTherapeutic profileFocal ischemic strokeTreatment armsYoung miceVehicle armSecondary outcomesParallel Detection of Lactate-Edited 1H MRSI and DMI to Differentiate Total and Active Lactate Pools in Brain Tumors
Liu Y, Kumaragamage C, Nixon T, McIntyre S, De Feyter H, de Graaf R. Parallel Detection of Lactate-Edited 1H MRSI and DMI to Differentiate Total and Active Lactate Pools in Brain Tumors. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/0038.Peer-Reviewed Original ResearchMetabolism in the human brain following oral consumption of a keto-ester for applications in alcohol use disorder (AUD) with 1H-MRSI
Virk M, Kitaneh R, Mignosa M, McIntyre S, Nixon T, DeMartini K, O’Malley S, Krystal J, De Feyter H, Angarita G, Mason G, de Graaf R, Kumaragamage C. Metabolism in the human brain following oral consumption of a keto-ester for applications in alcohol use disorder (AUD) with 1H-MRSI. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/0612.Peer-Reviewed Original ResearchOral administration of 2H9-choline at human dose for deuterium metabolic imaging of brain tumors
Osoliniec V, Thomas M, de Graaf R, De Feyter H. Oral administration of 2H9-choline at human dose for deuterium metabolic imaging of brain tumors. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/0039.Peer-Reviewed Original ResearchDeuterium metabolic imagingMetabolic imaging of brain tumorsTumor tissue extractsOrthotopic glioblastoma modelBrain tumor lesionsIn vivoDeuterated cholineMetabolic imaging methodPotential clinical translationTumor lesionsImaging of brain tumorsGlioblastoma modelLow dosesHuman doseOral administrationMetabolic imagingBrain tumorsClinical translationIV administrationDoseTumorAdministrationTissue extractsCholineImaging methodsParallel Detection of MRI and 1H MRSI for Efficient Multi-Contrast Anatomical and Metabolic Imaging.
de Graaf R, Thomas M, De Feyter H. Parallel Detection of MRI and 1H MRSI for Efficient Multi-Contrast Anatomical and Metabolic Imaging. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/1153.Peer-Reviewed Original ResearchDeuterium MRS for in vivo measurement of lipogenesis in the liver
Gursan A, de Graaf R, Thomas M, Prompers J, De Feyter H. Deuterium MRS for in vivo measurement of lipogenesis in the liver. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/2668.Peer-Reviewed Original ResearchA Manifold Learning-based Approach for Denoising in Deuterium Metabolic Imaging
Chi D, Han P, De Feyter H, de Graaf R, Ma C. A Manifold Learning-based Approach for Denoising in Deuterium Metabolic Imaging. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/3083.Peer-Reviewed Original ResearchMetabolism of choline and deuterated choline detected by 1H-14N 2D heteronuclear single-quantum coherence (HSQC) NMR
de Graaf R, Thomas M, De Feyter H. Metabolism of choline and deuterated choline detected by 1H-14N 2D heteronuclear single-quantum coherence (HSQC) NMR. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/3175.Peer-Reviewed Original ResearchLiver pH imaging for diagnosis and prognosis
Santana J, Kurdi S, Chapiro J, Hyder F, Coman D. Liver pH imaging for diagnosis and prognosis. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/1803.Peer-Reviewed Original ResearchTumor microenvironmentTumor-promoting phenotypeMouse liver tumor modelTumor microenvironment acidityImmunosuppressive tumor microenvironmentDensity of immune cellsImmune T cellsLiver tumor modelMouse liver tumorsLiver cancer therapyPhenotype of macrophagesT cellsImmune cellsLiver tumorsLow pHeTumor modelExtracellular acidosisCancer therapyCytotoxic activityImmune dynamicsMetabolic characterizationTumorMiceLiverSubmillimeter resolutionMultimodal imaging reveals gliomas are cooler than normal tissue
Coman D, Herman P, Rao J, Mihailovic J, Huang Y, Kaneko G, Hyder F. Multimodal imaging reveals gliomas are cooler than normal tissue. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/1939.Peer-Reviewed Original ResearchTransmembrane pH imaging distinguishes glycolytic and oxidative phenotypes in gliomas
Coman D, Mishra S, Kurdi S, Santana J, Hyder F. Transmembrane pH imaging distinguishes glycolytic and oxidative phenotypes in gliomas. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2025 DOI: 10.58530/2025/3064.Peer-Reviewed Original Research