2025
Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome
Zhang Z, Hu X, Du Q, Mo P, Chen X, Luo M, Jiang Q, Deng L, Xiong Y. Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome. BMC Infectious Diseases 2025, 25: 508. PMID: 40217170, DOI: 10.1186/s12879-025-10900-y.Peer-Reviewed Original ResearchConceptsDisseminated intravascular coagulationOutcomes of disseminated intravascular coagulationPresence of disseminated intravascular coagulationNon-DIC groupIndependent risk factorIntravascular coagulationClinical characteristicsRisk factorsDisseminated intravascular coagulation groupThrombocytopenia syndromeMultivariate logistic regression analysisAssociated with high mortalityIn-hospital mortality of patientsCumulative survival rateZhongnan Hospital of Wuhan UniversityMortality of patientsIn-hospital mortalitySevere feverLogistic regression analysisConsecutive patientsFerritin levelsD-dimerViral loadClinical dataCystatin CDelineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis
Bronstein M, Kummerfeld E, Bearden C, Cornblatt B, Walker E, Woods S, Mathalon D, Perkins D, Cadenhead K, Addington J, Cannon T, Vinogradov S. Delineating Empirically Plausible Causal Pathways to Suicidality Among People at Clinical High Risk for Psychosis. Journal Of Psychopathology And Clinical Science 2025, 134: 239-250. PMID: 39913476, DOI: 10.1037/abn0000969.Peer-Reviewed Original ResearchConceptsClinical high riskNorth American Prodrome Longitudinal StudyClinical high-risk samplesAttenuated psychosis symptomsPathways to suicideSuicide risk reductionPsychosis symptomsCausal pathwaysDepressed moodPsychosisIntervention effortsSelf-deprecationSuicideLongitudinal studyMeasurement time pointsStudy timepointsHigh riskSymptomsInterventionHopelessnessMoodTime pointsDepressionIndividualsDirect causesIncidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure
Barbano R, Jabbari B, Sadeghi M, Ukah A, Yue E, Ifantides K, Huang N, Swope D. Incidence of Dysphagia and Comorbidities in Patients with Cervical Dystonia, Analyzed by Botulinum Neurotoxin Treatment Exposure. Toxins 2025, 17: 148. PMID: 40137921, PMCID: PMC11945862, DOI: 10.3390/toxins17030148.Peer-Reviewed Original ResearchConceptsIncidence of dysphagiaCervical dystoniaComorbid conditionsContinuous health plan enrollmentCohort entry dateRate of dysphagiaRetrospective cohort studyPre-existing dysphagiaHealth plan enrollmentRisk factors of dysphagiaFactors of dysphagiaReal-world studyPotential adverse eventsPotential risk factorsPatient-level dataReal-world analysisAdverse eventsCD patientsCohort studyComorbid neurological conditionsLongitudinal patient-level dataCD diagnosisDysphagiaDysphagia riskPatientsIdentifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana
Mensah B, Mensah-Brown H, Partey F, Addo C, Buah G, Afudego G, Okyere D, Tetteh M, Boateng E, Wilson M, Paintsil E. Identifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana. BMC Public Health 2025, 25: 1042. PMID: 40102895, PMCID: PMC11917097, DOI: 10.1186/s12889-025-22254-w.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleGhanaHIV InfectionsHumansLost to Follow-UpMaleMiddle AgedRetrospective StudiesRisk FactorsYoung AdultConceptsFactors associated with LTFUHigh-burden districtsIdentified risk factorsRisk factorsAssociated with loss to follow-upPromote health literacyCare of personsBackgroundLoss to follow-upLoss to follow-upGlobal health initiativesAssociated with LTFULogistic regression modelsAntiretroviral therapyHealth literacyHIV careHealth initiativesFollow-upNo educationHIV clinicEffective interventionsEffectiveness of treatment strategiesLTFUHospital visitsCareMethodsA retrospective analysisThe burden of cardiovascular disease in Latin America and the Caribbean, 1990-2019: An analysis of the global burden of disease study
Alhuneafat L, Al Ta'ani O, Arriola-Montenegro J, Al-Ajloun Y, Naser A, Chaponan-Lavalle A, Ordaya-Gonzales K, Pertuz G, Maaita A, Jabri A, Altibi A, Al-Abdouh A, Van't Hof J, Gutierrez Bernal A. The burden of cardiovascular disease in Latin America and the Caribbean, 1990-2019: An analysis of the global burden of disease study. International Journal Of Cardiology 2025, 428: 133143. PMID: 40064205, DOI: 10.1016/j.ijcard.2025.133143.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsGlobal Burden of DiseaseBurden of cardiovascular diseaseCardiovascular diseaseRisk factorsMortality-to-incidence ratioGlobal burdenIschemic heart diseaseAge-standardized disability-adjusted life yearsGlobal Burden of Disease StudyDisability-adjusted life year ratesBurden of Disease StudyAge-standardized prevalenceComparative risk assessment frameworkCardiovascular disease prevalenceCardiovascular disease burdenBurden of diseaseLeading risk factorHeart diseaseTailored interventionsCountry-specific variationsElevated BMIRate of strokeHealthcare infrastructureSocio-economic factorsPerinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015)
Clark C, Wang R, Wiemels J, Metayer C, Deziel N, Ma X. Perinatal exposure to ambient fine particle air pollution and risk of childhood ewing sarcoma in a population-based case-control study in California (1988–2015). Environmental Health 2025, 24: 6. PMID: 40055781, DOI: 10.1186/s12940-025-01159-6.Peer-Reviewed Original ResearchConceptsHispanic childrenSarcoma riskControls frequency-matched to casesFrequency-matched to casesBirth yearPopulation-based case-control studyOdds ratioPM2.5 exposureConfidence intervalsAir pollution exposureCalifornia birth cohortNon-Hispanic childrenAmbient PM2.5 exposureFine particle air pollutionCase-control studyAmbient fine particulate matterHigher PM2.5 levelsMaternal residenceCancer riskMaternal educationPotential disparitiesBirth cohortHispanic ethnicityElevated oddsLinkage studiesPolygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification
D'Aoust T, Clocchiatti‐Tuozzo S, Rivier C, Mishra A, Hachiya T, Grenier‐Boley B, Soumaré A, Duperron M, Le Grand Q, Bouteloup V, Proust‐Lima C, Samieri C, Neuffer J, Sargurupremraj M, Chêne G, Helmer C, Thibault M, Amouyel P, Lambert J, Kamatani Y, Jacqmin‐Gadda H, Tregouët D, Inouye M, Dufouil C, Falcone G, Debette S. Polygenic score integrating neurodegenerative and vascular risk informs dementia risk stratification. Alzheimer's & Dementia 2025, 21: e70014. PMID: 40042447, PMCID: PMC11881617, DOI: 10.1002/alz.70014.Peer-Reviewed Original ResearchConceptsOlder community-dwelling peopleCommunity-dwelling peopleDementia risk stratificationVascular contribution to dementiaAssociated with dementia riskGenetic riskDementia clinical trialsApo E4Polygenic risk scoresGenetic risk groupsHigh-risk individualsDementia riskImprove risk predictionEast Asian ancestryAD-PRSPopulation-basedPolygenic scoresRisk stratificationMemory-clinic patientsPrevention programsClinical risk factorsDementiaClinical participantsRisk scoreAlzheimer's diseaseGlobal, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021
Collaborators G, Kerr J, Patton G, Cini K, Abate Y, Abbas N, Al Magied A, ElHafeez S, Abd-Elsalam S, Abdollahi A, Abdoun M, Abdulah D, Abdulkader R, Abdullahi A, Abeywickrama H, Abie A, Abiodun O, Abohashem S, Abtahi D, Abualruz H, Abubakar B, Abu-Gharbieh E, Abukhadijah H, Abu-Rmeileh N, Aburuz S, Abu-Zaid A, Adams L, Adane M, Addo I, Adedokun K, Adegoke N, Adesola R, Adetunji J, Adeyeoluwa T, Adiga U, Adnani Q, Afify A, Afolabi A, Afzal M, Afzal S, Agampodi S, Aghamiri S, Sobrinho C, Agyemang-Duah W, Ahinkorah B, Ahlstrom A, Ahmad A, Ahmad D, Ahmad F, Ahmad M, Ahmad N, Ahmad S, Ahmed A, Ahmed H, Ahmed L, Ahmed M, Ahmed M, Ahmed S, Ajami M, Akkaif M, Akrami A, Al Hamad H, Al Hasan S, Al Ta'ani Z, Al Thaher Y, Alalwan T, Al-Aly Z, Alam K, Al-amer R, Alansari A, Al-Ashwal F, Albashtawy M, Alemayehu B, Algammal A, Alhabib K, Alhuwail D, Ali A, Ali E, Ali M, Ali M, Ali R, Ali W, Alif M, Alimohamadi Y, Al-Jabi S, Aljofan M, Aljunid S, Alkhatib A, Almahmeed W, Al-Marwani S, Alomari M, Alqahtani S, Alqarni A, Alrawashdeh A, Alrimawi I, Alrousan S, Alshahrani N, Altaany Z, Altaf A, Alvi F, Alvis-Guzman N, Al-Wardat M, Al-Worafi Y, Aly H, Aly S, Alzoubi K, Mohammadi M, Amera T, Amiri S, Amu H, Amugsi D, Amusa G, Ananda R, Ancuceanu R, Ansari M, Ansari S, Anuoluwa B, Anuoluwa I, Anvari S, Anwar S, Anyasodor A, Arab J, Arabloo J, Arafat M, Aravkin A, Areda D, Aregawi B, Arifin H, Armocida B, Ärnlöv J, Arooj M, Arora A, Artamonov A, Artanti K, Arumugam A, Asghari-Jafarabadi M, Ashraf T, Asiamah-Asare B, Astell-Burt T, Athari S, Atorkey, Atreya A, Aumoldaeva Z, Awoke M, Awotidebe A, Aychiluhm S, Azimi A, Aziz S, Aziz S, Azzam A, Azzolino D, Babashahi M, Babu G, Badran A, Bagheri N, Bai R, Baig A, Bakkannavar S, Balakrishnan S, Baltatu O, Bam K, Banik R, Barati S, Bardhan M, Barqawi H, Barquera S, Barrow A, Barua L, Bastan M, Basu S, Bayat R, Bayih M, Bayleyegn N, Beeraka N, Behera P, Ramirez D, Bello U, Belo L, Bennett D, Bergami M, Berhe K, Berihun A, Bhadoria A, Bhala N, Bharadwaj R, Bhardwaj N, Bhardwaj P, Bhaskar S, Bhat A, Bhattacharjee P, Bhatti G, Bhatti J, Bilgin C, Bisignano C, Biswas B, Peroni B, Bjertness E, Bjørge T, Boloor A, Boppana S, Bosoka S, Bouaoud S, Boyko E, Braithwaite D, Brazo-Sayavera J, Brenner H, Bryazka D, Bugiardini R, Bui L, Bustanji Y, Butt N, Butt Z, Barsbay M, Calina D, Cámera L, Campos L, Cao S, Capodici A, Carletti C, Carvalho A, Carvalho M, Cattafesta M, Cattaruzza M, Cegolon L, Cembranel F, Cerin E, Cernigliaro A, Chadwick J, Chakraborty C, Chandrasekar E, Chang J, Chattu V, Chaudhary A, Chaurasia A, Chen A, Chen H, Chew N, Chi G, Chimoriya R, Ching P, Chitheer A, Choi D, Chong B, Chong C, Chopra H, Chopra S, Chou H, Choudhari S, Chung S, Chung S, Chutiyami M, Cogen R, Columbus A, Conrad N, Criqui M, Cruz-Martins N, da Silva A, Dadras O, Dai X, Dalakoti M, D'Amico E, Dandona L, Dandona R, D'Anna L, Danpanichkul P, Darcho S, Soltani R, Dash N, Davletov K, Dehghan A, Denova-Gutiérrez E, Molla M, Dergaa I, Desale A, Devanbu V, Devegowda D, Dhali A, Dhungel B, Diaz D, Dinu M, Chi T, do Prado C, Dodangeh M, Doegah P, Dohare S, Dokova K, Doku P, Dolatkhah N, D'Oria M, Dorostkar F, Doshi O, Doshi R, Dowou R, Du M, Dumith S, Dumuid D, Duncan B, Dutta S, Ebrahimi A, Edvardsson K, Sedeh A, Ekholuenetale M, Arab R, Bayoumy I, Eladl M, El-Ashker S, Elbarazi I, Elgendy I, Elhadi M, El-Metwally A, Elmonem M, Elnaem M, Elsheikh R, Eltaha C, Emeto T, Eslami M, Fabin N, Fadavian H, Fagbamigbe A, Fakhradiyev I, Faraji S, Farinha C, Faris M, Faris P, Kouhanjani M, Farooque U, Farrokhpour H, Fasusi S, Fazeli P, Fazylov T, Feizkhah A, Fekadu G, Feng X, Fernandez-Jimenez R, Ferreira N, Foigt N, Folayan M, Fomenkov A, Foroumadi R, Rodrigues C, Foschi M, Francis K, Franklin R, Gába A, Gadanya M, Gaidhane A, Galali Y, Gallus S, Ganesan B, Gangachannaiah S, Gebregergis M, Gebrehiwot M, Getacher L, Getie M, Ghadirian F, Ghazy R, Gil A, Gill T, Gillum R, Girmay A, Golechha M, Goleij P, Goulart A, Grada A, Grivna M, Grover A, Guan Z, Guarducci G, Gubari M, Guha A, Gulati S, Gunawardane D, Guo Z, Gupta B, Gupta R, Gupta R, Gupta V, Gutiérrez-Murillo R, Guzman-Esquivel J, Hadi N, Hadian Z, Hamdy N, Hamidi S, Hanif A, Hanifi N, Hankey G, Haq A, Haro J, Hasan F, Hashempour R, Hashempur M, Hasnain S, Hassan A, Hassan N, Hassanipour S, Rad A, Havmoeller R, Hay S, Hebert J, Hezam K, Hiraike Y, Hoang M, Holla R, Hossain A, Hosseinzadeh H, Hostiuc M, Hostiuc S, Htay Z, Hu M, Hu Y, Humayun A, Hundie T, Husseiny M, Hussien F, Huynh H, Hwang B, Ibrahim R, Ibrayeva A, Ikeda N, Ilesanmi O, Ilic I, Ilic M, Inbaraj L, Inok A, Iqbal K, Islam S, Islam F, Islam R, Islam M, Ismail N, Iso H, Isola G, Ituka M, Iwagami M, Iwu-Jaja C, Iyasu A, Jacob L, Jaffar S, Jahrami H, Jain A, Jain R, Jairoun A, Jakovljevic M, Javaid S, Jayapal S, Jayaram S, Jebasingh F, Jee S, Jema A, Jeswani B, Jonas J, Joseph N, Joshua C, Jozwiak J, Jürisson M, Kaambwa B, Kabir A, Kadashetti V, Kakkar A, Kalra S, Kanaan S, Kankam S, Kanmanthareddy A, Kanmodi K, Kantar R, Kar D, Karajizadeh M, Karakasis P, Behnagh A, Karimzadhagh S, Kassebaum N, Kauppila J, Kayode G, Kedir S, Kehagias D, Keshwani A, Kesse-Guyot E, Keykhaei M, Khajuria H, Khalili P, Khalilian A, Khalis M, Khan A, Khan M, Khan A, Khan M, Khan M, Khan M, Khan N, Khanal V, Khanmohammadi S, Khatatbeh M, Kheirkhah M, Khidri F, Khokhar M, Khosla A, Khosravi S, Khosrowjerdi M, Khusun H, Kim G, Kim J, Kim J, Kim M, Kim Y, Kimokoti R, Kisa A, Kishore L, Shivakumar K, Kokkorakis M, Kompani F, Korzh O, Kostev K, Laxminarayana S, Kretchy I, Kua C, Defo B, Kuddus M, Kulimbet M, Kulkarni V, Kumar G, Kumar V, Kundu S, Kunutsor S, Kurmi O, Kurniasari M, Kusuma D, Kytö V, La Vecchia C, Lacey B, Lahariya C, Lai D, Landires I, Larijani B, Lassi Z, Le H, Le N, Lee H, Lee M, Lee P, Lee S, Lee W, Li A, Li M, Li W, Li Y, Lim S, Lin J, Lin Q, Lindholm D, Lindstedt P, Liu J, Lo J, López-Gil J, Lorkowski S, Lucchetti G, Lugo A, Lutambi A, Feei Z, Gómez J, Maghbouli N, Mahalleh M, Mahmood N, Majeed A, Makris K, Rad E, Malekzadeh R, Malhotra K, Malik A, Malik I, Malta D, Mamun A, Manu E, Marateb H, Marino M, Marjani A, Martinez-Piedra R, Martorell M, März W, Marzouk S, Masrouri S, Mathangasinghe Y, Matozinhos F, Matthias T, Mattiello R, Maugeri A, Mazidi M, McPhail S, Mechili E, Salas M, Mehmood A, Mehrabani-Zeinabad K, Meto T, Meles H, Mendoza W, Menezes R, Mengistie E, Meo A, Mestrovic T, Mettananda C, Mettananda S, Miao H, Miller T, Ming W, Mirrakhimov E, Misganaw A, Mitiku H, Mittal M, Mohamed J, Mohamed M, Mohamed N, Mohammad T, Mohammad-Alizadeh-Charandabi S, Mohammadian-Hafshejani A, Mohammadzadeh I, Mohammed S, Mokdad A, Monasta L, Mondello S, Moni M, Namin S, Ghalibaf A, Moradi Y, Morrison S, Motappa R, Mubarik S, Mulita F, Mullany E, Munkhsaikhan Y, Murillo-Zamora E, Murray C, Musa S, Mustafa G, Muthu S, Mwita J, Myung W, Nafiu A, Nagel G, Naik G, Naik H, Nambi G, Nangia V, Nargus S, Nascimento G, Nassar M, Nauman J, Naureen Z, Navaratna S, Nawsherwan, Nayak B, 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A, Selvaraj S, Sendekie A, Sengupta P, Senol Y, Senthilkumaran S, Sepanlou S, Sethi Y, Seylani A, Shafie M, Shah S, Shahid S, Shahwan M, Shamim M, Shams-Beyranvand M, Shamsutdinova A, Shanawaz M, Shannawaz M, Sharath M, Sharifan A, Sharma M, Sharma U, Sharma V, Sheida F, Shenoy R, Shetty P, Shiferaw D, Shin M, Lapari M, Shiri R, Shittu A, Shool S, Shorofi S, Shrestha G, Shrestha R, Shuval K, Si Y, Sibuyi N, Siddig E, Siervo M, Silva D, Silva L, Singh A, Singh B, Singh H, Singh J, Singh K, Singh L, Singh M, Singh P, Singh S, Skryabina A, Smith A, Smith G, Soliman S, Soraneh S, Spartalis M, Srichawla B, Stanikzai M, Starodubova A, Straif K, Stubbs P, Subramaniyan V, Odidi M, Sulkowski A, Meo A, Sun Z, Sunny S, Sunuwar D, Swain C, Szarpak L, Y S, Tabarés-Seisdedos R, Tabatabaei S, Malazy O, Tabatabaeizadeh S, Tabatabai S, Tabche C, Tabish M, Taiba J, Tampa M, Tamuzi J, Tan K, Tanwar M, Tariq S, Tat N, Temsah M, Temsah R, Teramoto M, Terefa D, Tewari J, Thangaraju P, Thapar R, Thavamani A, Thirunavukkarasu S, Thomas J, Tiruneh S, Tiruye T, Titova M, Tiwari K, Tomo S, Tonelli M, Touvier M, Tovani-Palone M, Trabelsi K, Tran N, Tran T, Duc N, Trico D, Truyen T, Tsegay G, Tumurkhuu M, Tye S, Udoakang A, Ullah A, Ullah S, Ullah S, Umair M, Umar L, Umar U, Unim B, Upadhya D, Upadhyay E, Usman J, Ustunsoz D, Vaezghasemi M, Vaithinathan A, Van den Eynde J, Varghese J, Vasankari T, Vaziri S, Vellingiri B, Venketasubramanian N, Verma M, Verras G, Villalobos-Daniel V, Vladimirov S, Vlassov V, Vollset S, Vukovic R, Wahiduzzaman M, Wang C, Wang S, Wang X, Wang Y, Weerakoon K, Wei F, Wicaksana A, Wickramasinghe D, Wickramasinghe N, Willeit P, Wojewodzic M, Xia Q, Xiao G, Xie W, Xu S, Xu X, Yahya G, Yamagishi K, Yano Y, Yao H, Yarahmadi A, Yaribeygi H, Ye P, Yesuf S, Yin D, Yon D, Yonemoto N, Yu C, Yuan C, Yuce D, Yunusa I, Zamagni G, Zastrozhin M, Zeariya M, Zhang C, Zhang H, Zhang J, Zhang L, Zhang X, Zhang Z, Zhao H, Zheng D, Zhong A, Zhong C, Zhou J, Zhu B, Zhumagaliuly A, Zielińska M, Zitoun O, Zoghi G, Zou Z, Zyoud S, Gakidou E, Sawyer S, Azzopardi P. Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021. The Lancet 2025, 405: 785-812. PMID: 40049185, PMCID: PMC11920006, DOI: 10.1016/s0140-6736(25)00397-6.Peer-Reviewed Original ResearchConceptsHigh-income North AmericaSouthern sub-Saharan AfricaExcess body massObesity prevalenceAged 5Non-communicable diseases in adulthoodGlobal burdenGlobal Burden of Disease StudyBurden of Disease StudyGlobal Burden of DiseaseSub-Saharan AfricaCentral Latin AmericaNational prevalence of childrenRisk Factors StudySpatiotemporal Gaussian process regression modelingBurden of diseaseMales aged 5Prevalence of childrenConsequences of obesityOverweight prevalenceAdolescent overweightAge-standardisedBody massIndividuals aged 5Females aged 5Implications of gene × environment interactions in post-traumatic stress disorder risk and treatment
Seah C, Sidamon-Eristoff A, Huckins L, Brennand K. Implications of gene × environment interactions in post-traumatic stress disorder risk and treatment. Journal Of Clinical Investigation 2025, 135: e185102. PMID: 40026250, PMCID: PMC11870735, DOI: 10.1172/jci185102.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderGene x environment interactionsGenetic component of riskLimitations of genetic studiesTreating post-traumatic stress disorderExposure to traumatic stressPost-traumatic stress disorder riskInteraction of traumaGenetic screeningGenetic studiesGenetic componentEnvironment interactionMolecular mechanismsStress disorderPTSD riskTraumatic exposureTraumatic stressTraumatic experiencesDisorder riskGenetic factorsNovel therapeuticsBiological mechanismsGWASGeneral populationGenesIdentification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities
Loesch D, Garg M, Matelska D, Vitsios D, Jiang X, Ritchie S, Sun B, Runz H, Whelan C, Holman R, Mentz R, Moura F, Wiviott S, Sabatine M, Udler M, Gause-Nilsson I, Petrovski S, Oscarsson J, Nag A, Paul D, Inouye M. Identification of plasma proteomic markers underlying polygenic risk of type 2 diabetes and related comorbidities. Nature Communications 2025, 16: 2124. PMID: 40032831, PMCID: PMC11876343, DOI: 10.1038/s41467-025-56695-z.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersCardiovascular DiseasesComorbidityDiabetes Mellitus, Type 2Extracellular Matrix ProteinsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInsulin-Like Growth Factor Binding Protein 2MaleMiddle AgedMultifactorial InheritanceProteomicsRisk FactorsUnited KingdomConceptsPolygenic scoresNon-coding variantsEtiology of type 2 diabetesMolecular dataVariant effectsPathway enrichmentPlasma proteomic markersPotential therapeutic targetType 2 diabetesProteinDisease biologyPolygenic riskUK BiobankProteomic markersTherapeutic targetPathwayCirculating proteinsGenomeRisk of type 2 diabetesCardiometabolic scoreBiologyInteractive portalVariantsEnrichmentDiabetes comorbiditiesTranscatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients An Updated Meta-Analysis of Randomized Controlled Trials
Reddy R, Howard J, Mack M, Reardon M, Jørgensen T, Hørsted Thyregod H, Toff W, Van Mieghem N, Vora A, Makkar R, Kapadia S, Forrest J, Leon M, Ahmad Y. Transcatheter vs Surgical Aortic Valve Replacement in Lower-Risk Patients An Updated Meta-Analysis of Randomized Controlled Trials. Journal Of The American College Of Cardiology 2025, 85: 926-940. PMID: 40044297, DOI: 10.1016/j.jacc.2024.12.031.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementLower-risk patientsAortic valve replacementPooled survival analysisValve replacementIndividual participant dataPairwise meta-analysesFollow-upMeta-analysis of randomized controlled trialsLonger-term clinical outcomesReduced hazard of deathSevere aortic stenosisFixed effect assumptionsComposite of deathLonger-term follow-upAll-cause deathMean survival time modelsMeta-analysesHazard of deathRate of strokeRandomized controlled trialsSurvival time modelFrailty termProportional odds modelGLP-1RA Use and Thyroid Cancer Risk
Brito J, Herrin J, Swarna K, Ospina N, Montori V, Toro-Tobon D, Umpierrez G, Galindo R, Deng Y, Mickelson M, Shao H, Polley E, McCoy R. GLP-1RA Use and Thyroid Cancer Risk. JAMA Otolaryngology - Head & Neck Surgery 2025, 151: 243-252. PMID: 39847346, PMCID: PMC11907303, DOI: 10.1001/jamaoto.2024.4852.Peer-Reviewed Original ResearchConceptsDipeptidyl peptidase-4 inhibitorsModified intention-to-treatSodium-glucose cotransporter 2 inhibitorsTarget trial emulationGLP-1RA initiationComparative effectiveness studiesGLP-1RAThyroid cancerType 2 diabetesSecondary analysisMedicare fee-for-service planTrial emulationHazard ratioAssociated with increased overall riskIncident thyroid cancerDipeptidyl peptidase-4 inhibitor groupTreated with GLP-1RAGlucagon-like peptide-1 receptor agonistsHistory of thyroid cancerFee-for-service plansModified intention-to-treat analysisPeptide-1 receptor agonistsEnhanced early detectionGLP-1RA therapyPeptidase-4 inhibitorsOptimizing Psychological Health Across the Perinatal Period: An Update on Maternal Cardiovascular Health: A Scientific Statement From the American Heart Association.
Sharma G, Gaffey A, Hameed A, Kasparian N, Mauricio R, Marsh E, Beck D, Skowronski J, Wolfe D, Levine G. Optimizing Psychological Health Across the Perinatal Period: An Update on Maternal Cardiovascular Health: A Scientific Statement From the American Heart Association. Journal Of The American Heart Association 2025, 14: e041369. PMID: 39996493, DOI: 10.1161/jaha.125.041369.Peer-Reviewed Original ResearchConceptsMaternal cardiovascular healthPsychological healthCardiovascular healthAmerican Heart AssociationPerinatal periodCare delivery modelsMaternal psychological healthScientific statementPsychological health carePostpartum follow-upHeart AssociationPsychological health conditionsAssociated with adverse pregnancy outcomesCardiovascular outcomesMaternal mortalityAdverse pregnancy outcomesHealth careDelivery modelsHealth conditionsLong-term cardiovascular outcomesHealthStakeholder partnersOffspring neurodevelopmentPregnancy outcomesCareElevated initial blood kynurenine is associated with increased odds of post-stroke infection Kynurenine and post-stroke infection
Dylla L, Reisz J, Poisson S, Herson P, Sansing L, Monte A. Elevated initial blood kynurenine is associated with increased odds of post-stroke infection Kynurenine and post-stroke infection. Journal Of Stroke And Cerebrovascular Diseases 2025, 34: 108268. PMID: 40015349, DOI: 10.1016/j.jstrokecerebrovasdis.2025.108268.Peer-Reviewed Original ResearchConceptsPost-stroke infectionsAssociated with increased oddsTryptophan metabolitesHistory of diabetes mellitusEnd stage renal diseaseNIH Stroke Scale scoreConcentrations of kynurenineAcute ischemic stroke patientsMultivariate logistic regressionStage renal diseaseStroke Scale scoreCirculating kynurenineIschemic stroke onsetIschemic stroke patientsKynurenine concentrationsConcentrations of tryptophanEmergency department admissionsKynurenic acidDiabetes mellitusMortality of ischemic strokeRenal diseaseTryptophan metabolismOdds ratioQuinolinic acidImmune responseExamining multimorbidity contributors to dementia over time
Klee M, Markwardt S, Elman M, Han L, Leist A, Allore H, Quiñones A. Examining multimorbidity contributors to dementia over time. Alzheimer's & Dementia 2025, 21: e14589. PMID: 39988573, PMCID: PMC11847647, DOI: 10.1002/alz.14589.Peer-Reviewed Original ResearchConceptsAverage attributable fractionDementia incidenceDementia riskAttributable fractionChronic conditionsAssociated with increased risk of dementiaHealth and Retirement Study participantsMedicare fee-for-service beneficiariesAcute myocardial infarctionFee-for-service beneficiariesRetirement Study participantsRisk of dementiaPatterns of comorbiditiesAssociated with increased riskDementia casesMyocardial infarctionClaims algorithmIncident casesADRDStudy participantsIschemic heart diseaseDementiaConfidence intervalsMultimorbidityHeart diseaseIntegration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology
Erbay M, Manubolu V, Stein-Merlob A, Ferencik M, Mamas M, Lopez-Mattei J, Baldassarre L, Budoff M, Yang E. Integration and Potential Applications of Cardiovascular Computed Tomography in Cardio-Oncology. Current Cardiology Reports 2025, 27: 51. PMID: 39932640, PMCID: PMC11814013, DOI: 10.1007/s11886-025-02206-x.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesCoronary Artery DiseaseHumansNeoplasmsRisk FactorsTomography, X-Ray ComputedConceptsRadiation-induced cardiovascular diseaseCoronary artery diseaseCardiovascular diseaseCardiac massComputed tomographyArtery diseaseChest CT scans of patientsCT scans of patientsIncreased risk of CVDInvasive coronary angiographyRisk of cardiovascular diseaseRisk of complicationsScans of patientsCardiovascular computed tomographySeverity of cardiovascular diseaseNon-invasive imaging toolMonitoring of disease progressionManifestations of diseaseAsymptomatic patientsCardiac deteriorationIschemia evaluationCoronary angiographyPericardial diseaseCardiac changesRisk stratificationPredictors of Delayed Surgery After Distal Radius Fracture: A Large National Database Study.
Ratnasamy P, Allam O, Kammien A, Joo P, Luo X, Grauer J. Predictors of Delayed Surgery After Distal Radius Fracture: A Large National Database Study. Orthopedics 2025, 48: e75-e80. PMID: 39933104, DOI: 10.3928/01477447-20250204-01.Peer-Reviewed Original ResearchConceptsDistal radius fracturesDelayed surgeryRadius fracturesImmediate surgeryClinical factorsDistal radius fracture surgeryTime of surgeryCohort of patientsDemographics of patientsNon-clinical factorsFracture surgeryIndependent predictorsRetrospective studySurgical timeImpact patient outcomesMultivariate analysisSurgerySmoking statusComorbidity burdenPatientsWeek 0 to 2Patient outcomesWeek 3WeeksNon-clinicalSilent Myocardial Infarction and Risk of Stroke Recurrence: A Post Hoc Analysis of the IRIS Trial.
Ridha M, Zhang C, McCullough S, Viscoli C, Sharma R, Kamel H, Merkler A. Silent Myocardial Infarction and Risk of Stroke Recurrence: A Post Hoc Analysis of the IRIS Trial. Journal Of The American Heart Association 2025, 14: e037663. PMID: 39921499, DOI: 10.1161/jaha.124.037663.Peer-Reviewed Original ResearchConceptsSilent MISilent myocardial infarctionStroke recurrenceClinical MIAssociated with stroke recurrenceFirst-ever strokeMyocardial infarctionIschemic strokeTailored prevention strategiesRecurrent strokeVascular risk factorsHistory of hospitalizationRisk of stroke recurrenceEvidence of MIUnadjusted analysisPrevention strategiesInclusion criteriaSecondary outcomesECG evidence of MIPrimary outcomeRisk factorsMultivariate Cox regression analysisPost hoc analysisStrokeRegression analysisSpatial Correlates of Dementia and Disability After Intracerebral Hemorrhage.
Chen Y, Rivier C, Mora S, Torres Lopez V, Payabvash S, Sheth K, Harloff A, Falcone G, Rosand J, Mayerhofer E, Anderson C. Spatial Correlates of Dementia and Disability After Intracerebral Hemorrhage. Journal Of The American Heart Association 2025, 14: e037930. PMID: 39921496, DOI: 10.1161/jaha.124.037930.Peer-Reviewed Original ResearchConceptsFollow-up telephone interviewsElectronic health recordsAssociated with disabilityAssociated with dementiaDevelopment of dementiaDevelopment of disabilityIncident dementiaAssociated with intracerebral hemorrhageIntracerebral hemorrhageHealth recordsTelephone interviewsDementia conversionCohort studyDementiaDisabilityLobar intracerebral hemorrhageIntracerebral hemorrhage locationIntracerebral hemorrhagic lesionsFunctional outcomesNoncontrast computed tomography scanCohortMedian follow-up timeRight posterior limbOutcomesLeft temporo-occipital regionRisk Factors and Hospitalizations Associated with Pediatric Adenovirus and Rotavirus Infections in Northern Lebanon
Khalife S, Osman M, Moubayed S, Kassem I, Safadi D. Risk Factors and Hospitalizations Associated with Pediatric Adenovirus and Rotavirus Infections in Northern Lebanon. Medicina 2025, 61: 296. PMID: 40005411, PMCID: PMC11857655, DOI: 10.3390/medicina61020296.Peer-Reviewed Original ResearchConceptsAcute gastroenteritisRotavirus infectionRisk factorsSusceptibility to rotavirus infectionAssociated with breastfeedingBurden of rotavirusInfection rateLevel of maternal educationCross-sectional studyClinical dataRotavirus vaccinePediatric departmentFrequent viral agentsPediatric morbidityStool samplesLow infection rateTargeted public health interventionsChromatographic immunoassayNorth LebanonViral agentsInfectionProtective effectAdenovirusMaternal educationRotavirus
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