2025
Reduced removal of waste products from energy metabolism takes center stage in human brain aging
Mangia S, DiNuzzo M, Ponticorvo S, Dienel G, Behar K, Benveniste H, Hyder F, Giove F, Herculano-Houzel S, Petroff O, Eberly L, Filip P, Michaeli S, Rothman D. Reduced removal of waste products from energy metabolism takes center stage in human brain aging. Scientific Reports 2025, 15: 8127. PMID: 40057554, PMCID: PMC11890754, DOI: 10.1038/s41598-025-90342-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAgingBrainCarbon DioxideCerebrovascular CirculationEnergy MetabolismFemaleHumansHydrogen-Ion ConcentrationMaleMiddle AgedOxygen ConsumptionPositron-Emission TomographyYoung Adult[18F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [15O]Water.
Fu J, Juttukonda M, Garimella A, Salvatore A, Lois C, Ranasinghe A, Efthimiou N, Sari H, Aye W, Guehl N, El Fakhri G, Johnson K, Dickerson B, Izquierdo-Garcia D, Catana C, Price J. [18F]MK-6240 Radioligand Delivery Indices as Surrogates of Cerebral Perfusion: Bias and Correlation Against [15O]Water. Journal Of Nuclear Medicine 2025, 66: 410-417. PMID: 39947916, PMCID: PMC11876731, DOI: 10.2967/jnumed.124.268701.Peer-Reviewed Original ResearchMicroglia modulate the cerebrovascular reactivity through ectonucleotidase CD39
Fu Z, Ganesana M, Hwang P, Tan X, Kinkaid M, Sun Y, Bian E, Weybright A, Chen H, Sol-Church K, Eyo U, Pridans C, Quintana F, Robson S, Kumar P, Venton B, Schaefer A, Kuan C. Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39. Nature Communications 2025, 16: 956. PMID: 39843911, PMCID: PMC11754601, DOI: 10.1038/s41467-025-56093-5.Peer-Reviewed Original ResearchConceptsCerebral blood flowEctonucleotidases CD39Whisker stimulationResponse to whisker stimulationCerebrovascular reactivityDeletion of CD39Blood flowInjection of adenosine triphosphateModulation of cerebral blood flowRegulation of cerebral blood flowExtracellular adenosine triphosphateInjection of adenosineBorder-associated macrophagesMicroglia repopulationExtracellular adenosineAdenosine triphosphateFemale miceBlood flow anomaliesP2RY12 receptorCo-transmitterMouse modelPharmacological inhibitionCD39MicrogliaMice
2024
Single-Cell Analysis in Cerebrovascular Research: Primed for Breakthroughs and Clinical Impact
Albertson A, Winkler E, Yang A, Buckwalter M, Dingman A, Fan H, Herson P, McCullough L, Perez-Pinzon M, Sansing L, Sun D, Alkayed N. Single-Cell Analysis in Cerebrovascular Research: Primed for Breakthroughs and Clinical Impact. Stroke 2024, 56: 1082-1091. PMID: 39772596, DOI: 10.1161/strokeaha.124.049001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCerebrovascular CirculationCerebrovascular DisordersHumansSequence Analysis, RNASingle-Cell AnalysisRelative Cerebral Blood Flow as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status.
Salim H, Hamam O, Parilday G, Moustafa R, Ghandour S, Rutgers M, Sharara M, Cho A, Mazumdar I, Radmard M, Shin C, Montes D, Malhotra A, Romero J, Yedavalli V. Relative Cerebral Blood Flow as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status. Journal Of The American Heart Association 2024, 13: e034581. PMID: 39158542, DOI: 10.1161/jaha.124.034581.Peer-Reviewed Original ResearchConceptsAnterior circulation large vessel occlusionAcute ischemic strokeLarge vessel occlusionCollateral statusAdmission laboratory valuesChronic kidney diseaseBaseline characteristicsCerebral blood flowVessel occlusionPoor CSConsecutive patientsMale sexLaboratory valuesComputed tomography perfusion dataPretreatment computed tomography perfusionKidney diseasePredictors of favorable outcomeAssociation of baseline characteristicsRetrospective multicenter studyBlood flowPoor collateral statusIndications of CSCerebral perfusion parametersPatient baseline characteristicsRelative cerebral blood flowHypoperfusion Intensity Ratio as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large-Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status.
Hamam O, Gudenkauf J, Moustafa R, Cho A, Montes D, Sharara M, Moustafa A, Radmard M, Nabi M, Chen K, Sepehri S, Shin C, Mazumdar I, Kim M, Mohseni A, Malhotra A, Romero J, Yedavalli V. Hypoperfusion Intensity Ratio as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large-Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status. Journal Of The American Heart Association 2024, 13: e030897. PMID: 39158547, DOI: 10.1161/jaha.123.030897.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCerebrovascular CirculationCollateral CirculationComputed Tomography AngiographyFemaleHumansIschemic StrokeMaleMiddle AgedPerfusion ImagingRetrospective StudiesConceptsAnterior circulation large-vessel occlusionHypoperfusion intensity ratioLarge-vessel occlusionAcute ischemic strokeAdmission laboratory findingsCollateral statusAIS-LVOAdmission National InstitutesBaseline characteristicsLaboratory findingsConsecutive patientsPoor CSCryptogenic causeComputed tomography perfusion dataPretreatment computed tomography perfusionAssociation of baseline characteristicsPoor collateral statusPatient baseline characteristicsComputed tomography perfusionMultivariate logistic regressionInfarct growth rateMale patientsRetrospective studyClinical outcomesLogistic regression modelsDysregulated cerebral blood flow, rather than gray matter Volume, exhibits stronger correlations with blood inflammatory and lipid markers in depression
Kang L, Wang W, Nie Z, Gong Q, Yao L, Xiang D, Zhang N, Tu N, Feng H, Zong X, Bai H, Wang G, Wang F, Bu L, Liu Z. Dysregulated cerebral blood flow, rather than gray matter Volume, exhibits stronger correlations with blood inflammatory and lipid markers in depression. NeuroImage Clinical 2024, 41: 103581. PMID: 38430800, PMCID: PMC10944186, DOI: 10.1016/j.nicl.2024.103581.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersBrainCerebrovascular CirculationDepressionDepressive Disorder, MajorGray MatterHumansLipidsMagnetic Resonance ImagingSpin LabelsConceptsGray matter volumeCerebral blood flowMatter volumeArterial spin labelingRight middle temporal gyrusPredictors of MDDMiddle temporal gyrusImmune markersBrain functional changesProportion of MDDExploratory correlation analysisTumor necrosis factor-alphaBlood flowMDD patientsDepressive disorderAngular gyrusTemporal gyrusNecrosis factor-alphaMDDBrain regionsCerebral blood flow changesBlood lipid levelsInferior temporalCase-control comparisonCD4 count
2023
Trends on Near-Infrared Spectroscopy Associated With Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation
Zhao D, Shou B, Caturegli G, Whitman G, Kim B, Cho S, Investigators O. Trends on Near-Infrared Spectroscopy Associated With Acute Brain Injury in Venoarterial Extracorporeal Membrane Oxygenation. ASAIO Journal 2023, 69: 1083-1089. PMID: 37556554, PMCID: PMC10843160, DOI: 10.1097/mat.0000000000002032.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain InjuriesCerebrovascular CirculationExtracorporeal Membrane OxygenationFemaleHumansMaleMiddle AgedOximetryOxygenSpectroscopy, Near-InfraredConceptsCerebral near-infrared spectroscopyArea under the curveVenoarterial extracorporeal membrane oxygenationAcute brain injuryVA-ECMO patientsExtracorporeal membrane oxygenationVA-ECMOMembrane oxygenationCerebral regional oxygen saturationHypoxic ischemic brain injuryAssociated with acute brain injuryRegional oxygen saturationBrain injuryIschemic brain injuryECMO cannulationCerebral desaturationIntracranial hemorrhageConsecutive hoursNIRS monitoringOxygen saturationECMOIncreased oddsIschemic strokePatientsRSO 2Dynamic cerebral autoregulation in postpartum individuals with and without preeclampsia
Miller E, Katsidoniotaki M, Haghighi N, Dos Santos K, Booker W, Petersen N, Wapner R, Bello N, Kougioumtzoglou I, Marshall R. Dynamic cerebral autoregulation in postpartum individuals with and without preeclampsia. Pregnancy Hypertension 2023, 33: 39-45. PMID: 37524001, PMCID: PMC10528950, DOI: 10.1016/j.preghy.2023.07.176.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityBlood PressureCerebrovascular CirculationFemaleHomeostasisHumansPostpartum PeriodPre-EclampsiaPregnancyUltrasonography, Doppler, TranscranialConceptsDynamic cerebral autoregulationFirst week postpartumPostpartum individualsSevere featuresCerebral autoregulationPostpartum groupPreeclampsia diagnosisWeeks postpartumHistorical controlsFemale volunteersNon-pregnant female volunteersContinuous arterial blood pressureArterial blood pressureNon-pregnant volunteersDiagnosis of preeclampsiaHealthy non-pregnant female volunteersCerebrovascular complicationsBlood pressureTranscranial DopplerPostpartum participantsAutoregulatory responseFinger plethysmographyKruskal-Wallis testPreeclampsiaAutoregulation parametersSpatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb
James S, Sanggaard S, Akif A, Mishra S, Sanganahalli B, Blumenfeld H, Verhagen J, Hyder F, Herman P. Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 1891-1904. PMID: 37340791, PMCID: PMC10676132, DOI: 10.1177/0271678x231183887.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarbon DioxideCerebral CortexCerebrovascular CirculationHypercapniaMiceNeurovascular CouplingOlfactory BulbConceptsVasodilatory responseCerebral cortexNeurovascular couplingOlfactory bulbNeuronal activityBrief sensory stimuliRegional neurovascular couplingStimulus-induced activityHypercapnia challengeVascular toneNeuronal deactivationHemodynamic responseNeuronal excitabilityNeuronal responsesCalcium transientsBrain functionHemodynamic signalsSensory stimuliVasodilationHypercapniaCortexMiceCareful appraisalStimuliMetabolic wasteMeasurement of Cerebral Perfusion Indices from the Early Phase of [18F]MK6240 Dynamic Tau PET Imaging
Guehl N, Dhaynaut M, Hanseeuw B, Moon S, Lois C, Thibault E, Fu J, Price J, Johnson K, El Fakhri G, Normandin M. Measurement of Cerebral Perfusion Indices from the Early Phase of [18F]MK6240 Dynamic Tau PET Imaging. Journal Of Nuclear Medicine 2023, 64: 968-975. PMID: 36997330, PMCID: PMC10241011, DOI: 10.2967/jnumed.122.265072.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAniline CompoundsBrainCerebrovascular CirculationCognitive DysfunctionHumansPositron-Emission TomographyConceptsTime-activity curvesCerebral perfusionMetabolite-corrected arterial input functionBrain time-activity curvesEarly phaseRegional time-activity curvesIndices of cerebral perfusionDynamic [<sup>18</sup>FBlood-brain barrierPlasma to brain tissueStatistically significant differenceArterial blood samplesForty-nine subjectsCNArterial input functionPathophysiological mechanismsPerfusion indicatorsPET imagingBlood samplesSignificant differenceSurrogate indexNoninvasive estimationAnatomical informationCompound BForty-nineEmbracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial
Morais A, Locascio J, Sansing L, Lamb J, Nagarkatti K, Imai T, van Leyen K, Aronowski J, Koenig J, Bosetti F, Lyden P, Ayata C, Bosetti F, Koenig J, Lyden P, Lamb J, Nagarkatti K, Hess D, Kamat P, Khan M, Dhandapani K, Arbab A, Siddiqui S, Smith C, Nisar M, Leira E, Chauhan A, Dhanesha N, Patel R, Kumskova M, Thedens D, Wang K, Ayata C, Morais A, Imai T, Qin T, Jin X, Erdogan T, Yu L, Mandeville J, Kimberly W, Whittier J, Lo E, Arai K, Van Leyen K, Sansing L, Hyder F, Mihailovic J, Sanganahalli B, Diaz-Perez S, Velazquez S, Beatty H, Johnson C, Herman A, Boisserand L, Immakavar E, Koehler R, Dawson T, Dawson V, Shi Y, Avery B, Lannon S, Bibic A, Akhter K, Karuppagounder S, Aronowski J, McCullough L, Obertas L, Goh A, Huang S, Chauhan A. Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial. Stroke 2023, 54: 620-631. PMID: 36601951, PMCID: PMC9870939, DOI: 10.1161/strokeaha.122.040638.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebrovascular CirculationDisease Models, AnimalInfarction, Middle Cerebral ArteryIschemic Attack, TransientMiceMulticenter Studies as TopicResearch DesignStrokeConceptsTotal anesthesia durationAnesthesia durationIndependent predictorsMultivariable analysisClinical trialsTransient focal cerebral ischemiaFocal cerebral ischemiaCerebral blood flowLaser Doppler flowCentralized randomizationModified intentionTreat populationExperimental strokeCerebral ischemiaDoppler flowRodent modelsMCAOBlood flowNetwork trialFlow dropPreclinical trialsMouse cohortsStudy designTrialsTrial onset
2022
Cerebral Blood Flow of the Frontal Lobe in Untreated Children with Trigonocephaly versus Healthy Controls: An Arterial Spin Labeling Study
Long A, Persing J, Alperovich M. Cerebral Blood Flow of the Frontal Lobe in Untreated Children with Trigonocephaly versus Healthy Controls: An Arterial Spin Labeling Study. Plastic & Reconstructive Surgery 2022, 151: 526e-527e. PMID: 36730155, DOI: 10.1097/prs.0000000000009946.Peer-Reviewed Original ResearchStress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating
Bini J, Parikh L, Lacadie C, Hwang JJ, Shah S, Rosenberg SB, Seo D, Lam K, Hamza M, De Aguiar RB, Constable T, Sherwin RS, Sinha R, Jastreboff AM. Stress-level glucocorticoids increase fasting hunger and decrease cerebral blood flow in regions regulating eating. NeuroImage Clinical 2022, 36: 103202. PMID: 36126514, PMCID: PMC9486604, DOI: 10.1016/j.nicl.2022.103202.Peer-Reviewed Original ResearchMeSH KeywordsAppetiteCerebrovascular CirculationGlucocorticoidsHumansHungerHydrocortisoneInsulinMagnetic Resonance ImagingConceptsCerebral blood flowRegional cerebral blood flowBlood flowMetabolic hormonesRandomized double-blind cross-over designDouble-blind cross-over designStress level glucocorticoidsPrimary sensory cortexPerfusion magnetic resonanceCross-over designMedial temporal gyrusWhole-brain voxelMedial brainstemSaline daysOvernight infusionCBF responseHunger ratingsPlasma insulinGlucocorticoid effectsHedonic signalsObesity riskLimbic regionsFood intakeNeural regulationDistinct brain networks
2021
Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome
Nogueira R, Aries M, Minhas J, Petersen N, Xiong L, Kainerstorfer J, Castro P. Review of studies on dynamic cerebral autoregulation in the acute phase of stroke and the relationship with clinical outcome. Cerebrovascular And Brain Metabolism Reviews 2021, 42: 430-453. PMID: 34515547, PMCID: PMC8985432, DOI: 10.1177/0271678x211045222.Peer-Reviewed Original ResearchConceptsDynamic cerebral autoregulationAcute phaseClinical outcomesCerebral autoregulationAcute ischemic strokeCerebral hemodynamic parametersPotential therapeutic targetCerebrovascular disease statesAcute strokeIschemic strokeStroke onsetCerebral perfusionCerebral circulationIntracerebral hemorrhageHigh morbidityHemodynamic parametersIndividual patientsPerfusion interventionsNew therapiesTherapeutic targetHemodynamic aspectsPatientsAdditional treatmentDisease statesRelevant studiesContinuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays
Wang C, Qi B, Lin M, Zhang Z, Makihata M, Liu B, Zhou S, Huang Y, Hu H, Gu Y, Chen Y, Lei Y, Lee T, Chien S, Jang K, Kistler E, Xu S. Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays. Nature Biomedical Engineering 2021, 5: 749-758. PMID: 34272524, DOI: 10.1038/s41551-021-00763-4.Peer-Reviewed Original ResearchMeSH KeywordsCerebrovascular CirculationHeartHemodynamicsHumansMicroarray AnalysisMonitoring, PhysiologicSignal-To-Noise RatioUltrasonography, DopplerWearable Electronic DevicesConceptsUltrasonic phased arrayPhased arrayStretchable wearable devicesContinuous monitoring of physiological signalsMonitoring of physiological signalsDepth of signal penetrationIncident angleDoppler spectrumSignal penetrationWearable diagnosticsFlow waveformsArrayUltrasound beamWearable devicesBlood flow waveformsResolved signalsReal timeDevicesCerebral blood supplyContinuous monitoringHealthy volunteersPenumbra Consumption Rates Based on Time-to-Maximum Delay and Reperfusion Status: A Post Hoc Analysis of the DEFUSE 3 Trial
Yaghi S, Raz E, Dehkharghani S, Riina H, McTaggart R, Jayaraman M, Prabhakaran S, Liebeskind DS, Khatri P, Mac Grory B, Al-Mufti F, Lansberg M, Albers G, de Havenon A. Penumbra Consumption Rates Based on Time-to-Maximum Delay and Reperfusion Status: A Post Hoc Analysis of the DEFUSE 3 Trial. Stroke 2021, 52: 2690-2693. PMID: 34157865, DOI: 10.1161/strokeaha.120.033806.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBrain IschemiaCerebral RevascularizationCerebrovascular CirculationEndovascular ProceduresFemaleHumansMaleMiddle AgedStrokeThrombectomyTime-to-TreatmentConceptsDEFUSE-3 trialsLarge vessel occlusionPenumbral tissueVessel occlusionMismatch volumeAcute large vessel occlusionAnterior circulation occlusionEndovascular thrombectomy patientsAcute ischemic strokePost Hoc AnalysisReperfusion statusThrombectomy patientsTICI 0Cerebral infarctionEndovascular thrombectomyIschemic strokeUntreated patientsPrimary outcomeSalvageable tissueTreatment modalitiesHoc AnalysisPerfusion timePatientsNatural historyOcclusionPartial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease
Lu Y, Toyonaga T, Naganawa M, Gallezot JD, Chen MK, Mecca AP, van Dyck CH, Carson RE. Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease. NeuroImage 2021, 238: 118248. PMID: 34119639, PMCID: PMC8454285, DOI: 10.1016/j.neuroimage.2021.118248.Peer-Reviewed Original ResearchFetal cerebrovascular impedance is reduced in left congenital diaphragmatic hernia
Kosiv K, Moon‐Grady A, Hogan W, Keller R, Rapoport R, Rogers E, Feldstein V, Lee H, Peyvandi S. Fetal cerebrovascular impedance is reduced in left congenital diaphragmatic hernia. Ultrasound In Obstetrics And Gynecology 2021, 57: 386-391. PMID: 32068925, PMCID: PMC7431368, DOI: 10.1002/uog.21992.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalCardiography, ImpedanceCase-Control StudiesCerebrovascular CirculationEchocardiographyElectric ImpedanceFemaleFetal DevelopmentFetusFunctional LateralityGestational AgeHernias, Diaphragmatic, CongenitalHumansMiddle Cerebral ArteryNeurodevelopmental DisordersPregnancyPulsatile FlowUltrasonography, PrenatalUmbilical ArteriesConceptsLeft ventricular cardiac outputLeft-sided CDHCongenital diaphragmatic herniaMCA-PI Z-scoreMCA-PICerebral blood flowCardiac outputRight-sided CDHPulsatility indexHead circumferenceBiparietal diameterCDH survivorsBlood flowSmall left-sided cardiac structuresMiddle cerebral artery pulsatility indexRight-sided congenital diaphragmatic herniaLeft-sided congenital diaphragmatic herniaLeft-sided cardiac structuresPercentage of COCerebral artery pulsatility indexGestational age-matched controlsZ-scoreMCA PI valuesArtery pulsatility indexSignificant mass effectIntravenous Infusion of Mesenchymal Stem Cells Enhances Therapeutic Efficacy of Reperfusion Therapy in Cerebral Ischemia
Kiyose R, Sasaki M, Kataoka-Sasaki Y, Nakazaki M, Nagahama H, Magota H, Oka S, Ukai R, Takemura M, Yokoyama T, Kocsis JD, Honmou O. Intravenous Infusion of Mesenchymal Stem Cells Enhances Therapeutic Efficacy of Reperfusion Therapy in Cerebral Ischemia. World Neurosurgery 2021, 149: e160-e169. PMID: 33618048, DOI: 10.1016/j.wneu.2021.02.056.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowInfused mesenchymal stem cellsReperfusion therapyPermanent MCAOIntravenous infusionMesenchymal stem cellsTherapeutic efficacyTransient middle cerebral artery occlusion modelMiddle cerebral artery occlusion modelArterial spin labeling magnetic resonance imagingArtery occlusion modelStandard therapeutic strategyTransient MCAO modelCerebral blood flowBehavioral functionsNon-favorable outcomeRat model systemStem cellsMCAO groupStroke inductionAcute strokeCerebral ischemiaNeurologic functionInfusion groupMCAO model
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply