Jian Yue, PhD
Associate Research ScientistDownloadHi-Res Photo
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Associate Research Scientist
Biography
Dr. Yue earned his Ph.D. in Biochemistry and Molecular Biology from the University of Science and Technology of China in December, 2020, and also worked as a postdoctoral researcher at the Southern University of Science and Technology. Dr. Yue utilizes various techniques, such as X-ray crystallography, cryo-electron microscopy (cryo-EM), and biochemical methods, to investigate the structure-function relationship of proteins involved in critical physiological processes in bacterial, yeast, and human cells.
In May 2023, Dr. Jian joined the Liu laboratory at Yale School of Medicine and the Microbial Sciences Institute to further develop his expertise in cryo-electron tomography (cryo-ET) and correlative approaches. He investigates bacterial type IV secretion system (T4SS), utilizing high-throughput cryo-ET techniques to visualize and determine high-resolution 3D structures in their native context.
Last Updated on July 26, 2023.
Appointments
Microbial Pathogenesis
Associate Research ScientistPrimary
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Education & Training
- PhD
- University of Science and Technology of China, Biochemistry and Molecular Biology
Research
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Overview
Medical Research Interests
Bacterial Secretion Systems; Cryoelectron Microscopy; Electron Microscope Tomography; Host Microbial Interactions; Molecular Structure
ORCID
0009-0002-4960-940X- View Lab Website
Liu Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jian Yue's published research.
Publications Timeline
A big-picture view of Jian Yue's research output by year.
Research Interests
Research topics Jian Yue is interested in exploring.
Jun Liu, PhD
Wangbiao (Seven) Guo
Huaxin Yu
Jing Yan, PhD
Chunyan Wang, PhD
Craig Roy, PhD
18Publications
216Citations
Cryoelectron Microscopy
Publications
2026
Near-atomic in situ architecture and membrane-coupled dynamics of the Vibrio cholerae sheathed flagellum
Guo W, Yue J, Park J, Valverde-Mendez D, Botting J, Yu H, Sen A, Kumar R, Yan J, Yildiz F, Liu J. Near-atomic in situ architecture and membrane-coupled dynamics of the Vibrio cholerae sheathed flagellum. Nature Communications 2026, 17: 9199. PMID: 42660870, DOI: 10.1038/s41467-026-75593-6.Peer-Reviewed Original ResearchAltmetricCryo-EM Structures of Phage T4 Infection Intermediate
Shao Q, Dong J, Wang A, Hu H, Yue J, Li H, Li Y, Zhang Q, Liu J, Sun L, Fokine A, Rao V, Tao P, Fang Q. Cryo-EM Structures of Phage T4 Infection Intermediate. Journal Of Molecular Biology 2026, 438: 169938. PMID: 42401366, DOI: 10.1016/j.jmb.2026.169938.Peer-Reviewed Original ResearchAltmetric
2025
Structural basis of bacteriophage Ur-lambda infection initiation
Yu H, Wang C, Yue J, Guo W, Molineux I, Liu J. Structural basis of bacteriophage Ur-lambda infection initiation. Science Advances 2025, 11: eadw7914. PMID: 41237242, PMCID: PMC12617516, DOI: 10.1126/sciadv.adw7914.Peer-Reviewed Original ResearchCitationsAltmetricStructures of the sheathed flagellum reveal mechanisms of assembly and rotation in Vibrio cholerae
Guo W, Zhang S, Park J, Stanton V, Asp M, Herrera H, Tai J, Yue J, Wang J, Guo J, Kumar R, Botting J, Yan J, Klose K, Yildiz F, Liu J. Structures of the sheathed flagellum reveal mechanisms of assembly and rotation in Vibrio cholerae. Nature Microbiology 2025, 10: 3305-3314. PMID: 41174224, PMCID: PMC13137154, DOI: 10.1038/s41564-025-02161-x.Peer-Reviewed Original ResearchCitationsAltmetricIn situ structures of the Legionella Dot/Icm T4SS identify the DotA–IcmX complex as the gatekeeper for effector translocation
Yue J, Heydari S, Park D, Chetrit D, Tachiyama S, Guo W, Botting J, Wu S, Roy C, Liu J. In situ structures of the Legionella Dot/Icm T4SS identify the DotA–IcmX complex as the gatekeeper for effector translocation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2516300122. PMID: 40986344, PMCID: PMC12501162, DOI: 10.1073/pnas.2516300122.Peer-Reviewed Original ResearchCitationsAltmetricA flexible peptide linking the periplasmic and cytoplasmic domains of MxiG controls type III secretion signaling and stable sorting platform assembly in Shigella
Tachiyama S, Muthuramalingam M, Whittier S, Chang Y, Yue J, Younis W, Picking W, Liu J, Picking W. A flexible peptide linking the periplasmic and cytoplasmic domains of MxiG controls type III secretion signaling and stable sorting platform assembly in Shigella. Frontiers In Cellular And Infection Microbiology 2025, 15: 1611779. PMID: 40831705, PMCID: PMC12358396, DOI: 10.3389/fcimb.2025.1611779.Peer-Reviewed Original ResearchCitationsAltmetricFlgY, PflA, and PflB form a spoke–ring network in the high-torque flagellar motor of Helicobacter pylori
Tachiyama S, Rosinke K, Khan M, Zhou X, Xin Y, Botting J, Yue J, Roujeinikova A, Hoover T, Liu J. FlgY, PflA, and PflB form a spoke–ring network in the high-torque flagellar motor of Helicobacter pylori. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2421632122. PMID: 40261933, PMCID: PMC12054838, DOI: 10.1073/pnas.2421632122.Peer-Reviewed Original ResearchCitationsAltmetricFlbB forms a distinctive ring essential for periplasmic flagellar assembly and motility in Borrelia burgdorferi
Botting J, Rahman M, Xu H, Yue J, Guo W, Del Mundo J, Hammel M, Motaleb M, Liu J. FlbB forms a distinctive ring essential for periplasmic flagellar assembly and motility in Borrelia burgdorferi. PLOS Pathogens 2025, 21: e1012812. PMID: 39777417, PMCID: PMC11750108, DOI: 10.1371/journal.ppat.1012812.Peer-Reviewed Original ResearchCitationsAltmetric
2023
Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis
Xie T, Liu P, Wu X, Dong F, Zhang Z, Yue J, Mahawar U, Farooq F, Vohra H, Fang Q, Liu W, Wattenberg B, Gong X. Ceramide sensing by human SPT-ORMDL complex for establishing sphingolipid homeostasis. Nature Communications 2023, 14: 3475. PMID: 37308477, PMCID: PMC10261145, DOI: 10.1038/s41467-023-39274-y.Peer-Reviewed Original ResearchCitationsAltmetricMechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex
Liu P, Xie T, Wu X, Han G, Gupta S, Zhang Z, Yue J, Dong F, Gable K, Niranjanakumari S, Li W, Wang L, Liu W, Yao R, Cahoon E, Dunn T, Gong X. Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex. Science Advances 2023, 9: eadg0728. PMID: 36989369, PMCID: PMC10058238, DOI: 10.1126/sciadv.adg0728.Peer-Reviewed Original ResearchCitationsAltmetric
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