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High-Throughput Cryo-ET

The Liu laboratory is dedicated to developing a high-throughput cryo-electron tomography (cryo-ET) pipeline for high-resolution structure determination of molecular machines in cells.

Our state-of-the-art imaging system has been utilized to gain molecular insights into fundamental biochemical processes: bacterial motility, chemotactic signaling, protein secretion, and DNA translocation.

Cryo-electron tomography reveals cellular architecture of Treponema pallidum

Video by Jun Liu

00:00:37

Molecular mechanism for rotational switching of the bacterial flagellar motor

Credit: Yunjie Chang, Kai Zhang, Brittany L. Carroll, Xiaowei Zhao, Nyles W. Charon, Steven J. Norris, Md A. Motaleb, Chunhao Li , Jun Liu

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