Faye Rogers, PhD
Professor of Therapeutic RadiologyDownloadHi-Res Photo
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Appointments
Therapeutic Radiology
Primary
Additional Titles
Associate Cancer Center Director, YCC Collaborative Excellence
Vice Chair for Collaborative Excellence, Therapeutic Radiology
Associate Director, Yale MD-PhD Program
Director, Yale BioMed Amgen Scholars Program
Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
Appointments
Therapeutic Radiology
Primary
Additional Titles
Associate Cancer Center Director, YCC Collaborative Excellence
Vice Chair for Collaborative Excellence, Therapeutic Radiology
Associate Director, Yale MD-PhD Program
Director, Yale BioMed Amgen Scholars Program
Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
Appointments
Therapeutic Radiology
Primary
Additional Titles
Associate Cancer Center Director, YCC Collaborative Excellence
Vice Chair for Collaborative Excellence, Therapeutic Radiology
Associate Director, Yale MD-PhD Program
Director, Yale BioMed Amgen Scholars Program
Contact Info
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
About
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Titles
Professor of Therapeutic Radiology
Associate Cancer Center Director, YCC Collaborative Excellence; Vice Chair for Collaborative Excellence, Therapeutic Radiology; Associate Director, Yale MD-PhD Program; Director, Yale BioMed Amgen Scholars Program
Appointments
Therapeutic Radiology
ProfessorPrimary
Other Departments & Organizations
- BioMed Amgen Scholars Program
- DNA Damage and Genome Integrity
- MD-PhD Program
- Molecular Medicine, Pharmacology, and Physiology
- Program in Translational Biomedicine (PTB)
- Radiobiology
- Therapeutic Radiology
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Ventures
- YCC Collaborative Excellence
- YSM Office of Collaborative Excellence
Education & Training
- PhD
- University of Maryland at Baltimore (1998)
Research
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Overview
Medical Research Interests
Apoptosis; Biochemistry; Breast Neoplasms; DNA Repair; Drug Design; Genomic Instability; Nucleic Acids; Radiation Oncology
ORCID
0000-0002-1454-9892
Research at a Glance
Yale Co-Authors
Frequent collaborators of Faye Rogers's published research.
Publications Timeline
A big-picture view of Faye Rogers's research output by year.
Research Interests
Research topics Faye Rogers is interested in exploring.
Peter M. Glazer, MD, PhD
Adam Krysztofiak, PhD
Daniel Andrés Colón-Ríos
Yanfeng Liu
Leonard Milstone, MD
Demetrios Braddock, MD, PhD
26Publications
617Citations
DNA Repair
Apoptosis
Genomic Instability
Breast Neoplasms
Nucleic Acids
Publications
2025
PARP inhibitor resistance in IDH1-mutant cancers due to loss of end protection factors, 53BP1 and REV7
Colón-Ríos D, Dow J, Krysztofiak A, Liu Y, Rogers F, Glazer P. PARP inhibitor resistance in IDH1-mutant cancers due to loss of end protection factors, 53BP1 and REV7. NAR Cancer 2025, 7: zcaf047. PMID: 41357766, PMCID: PMC12675010, DOI: 10.1093/narcan/zcaf047.Peer-Reviewed Original ResearchThis study investigates how IDH1-mutant cancers develop resistance to PARP inhibitors through loss of end protection factors, 53BP1 and REV7, and shows that the drug cediranib can overcome this resistance, highlighting potential therapeutic strategies for improving cancer treatment outcomes.Cell-penetrating antibody enhances nuclear delivery of triplex-forming oligonucleotides targeting HER2-positive cancers
Minnah A, Tubéns N, Krysztofiak A, Liu Y, Glazer P, Rogers F. Cell-penetrating antibody enhances nuclear delivery of triplex-forming oligonucleotides targeting HER2-positive cancers. Molecular Therapy - Nucleic Acids 2025, 36: 102720. PMID: 41127334, PMCID: PMC12538099, DOI: 10.1016/j.omtn.2025.102720.Peer-Reviewed Original ResearchAltmetricConceptsNucleic acid therapiesNuclear deliveryBreast cancer modelHER2-positive cancersTriplex-forming oligonucleotidesCancer treatment optionsTumor-targeting propertiesPrecision cancer therapyAnti-DNA monoclonal antibodyTreatment optionsCancer modelsCell-penetrating antibodiesBinding extracellular DNACancer therapyClinical translationMonoclonal antibodiesDelivery efficiencyIn vitroNecrotic regionsTherapyExtracellular DNADelivery systemAntibodiesDeliveryHER2
2024
Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition
Rackear M, Quijano E, Ianniello Z, Colón-Ríos D, Krysztofiak A, Abdullah R, Liu Y, Rogers F, Ludwig D, Dwivedi R, Bleichert F, Glazer P. Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition. Oncotarget 2024, 15: 699-713. PMID: 39352803, PMCID: PMC11444335, DOI: 10.18632/oncotarget.28651.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTumor targetingMonoclonal antibody therapyTumor-specific targetingCell uptakeNucleic acid bindingCell surface antigensAntibody therapyHuman variantsClinical successCell-penetrating antibodiesAcid bindingSystemic administrationSurface antigensTumorRAD51 inhibitionAntibody platformMechanism of cell penetrationBind RAD51AntibodiesFull-lengthSpecific targetsCell penetrationDisease targetsCellsAutoantibodies
2022
The Pathogenic R3052W BRCA2 Variant Disrupts Homology-Directed Repair by Failing to Localize to the Nucleus
Jimenez-Sainz J, Krysztofiak A, Garbarino J, Rogers F, Jensen RB. The Pathogenic R3052W BRCA2 Variant Disrupts Homology-Directed Repair by Failing to Localize to the Nucleus. Frontiers In Genetics 2022, 13: 884210. PMID: 35711920, PMCID: PMC9197106, DOI: 10.3389/fgene.2022.884210.Peer-Reviewed Original ResearchCitationsAltmetricConceptsDominant-negative alleleDNA damage responseDNA repair functionDNA strand exchangeHomology-directed repairGenome instabilityCellular functionsDamage responseDNA bindingNegative allelesStrand exchangeRepair functionGermline missense variantsCell survivalFunction mutationsMissense variantsRAD51Pathogenic allelesSimple lossPARP inhibitorsCytoplasmProteinAllelesHomologyDNA
2021
Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair
Dow J, Krysztofiak A, Liu Y, Colon-Rios DA, Rogers FA, Glazer PM. Vulnerability of IDH1-Mutant Cancers to Histone Deacetylase Inhibition via Orthogonal Suppression of DNA Repair. Molecular Cancer Research 2021, 19: 2057-2067. PMID: 34535560, PMCID: PMC8642278, DOI: 10.1158/1541-7786.mcr-21-0456.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHistone deacetylase inhibitor vorinostatPatient-derived tumor xenograftsHomology-directed repairIsocitrate dehydrogenase 1/2 mutationsHistone deacetylase inhibitionIDH1 mutant cellsGreater cell deathHDACi treatmentInhibitor vorinostatTumor xenograftsDeacetylase inhibitionIDH1/2 mutationsPotential biomarkersSpecific cancersMutant cancersCancerCancer cellsDNA repair defectsMalignancyVorinostatDNA double-strand breaksGliomasHistone hypermethylationCell deathPARPiDirect targeting of amplified gene loci for proapoptotic anticancer therapy
Kaushik Tiwari M, Colon-Rios DA, Tumu HCR, Liu Y, Quijano E, Krysztofiak A, Chan C, Song E, Braddock DT, Suh HW, Saltzman WM, Rogers FA. Direct targeting of amplified gene loci for proapoptotic anticancer therapy. Nature Biotechnology 2021, 40: 325-334. PMID: 34711990, PMCID: PMC8930417, DOI: 10.1038/s41587-021-01057-5.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDNA double-strand breaksTriplex-forming oligonucleotidesDNA damage responseDouble-strand breaksDrug resistanceGene amplificationP53-independent apoptosisHER2-positive breastOvarian cancer modelHuman tumor xenograftsInduction of apoptosisGenomic lociNumber of drugsCellular functionsDamage responseGene locusProtein productsHER2-positive cancer cellsDriver genesClinical efficacyCombat drug resistanceDNA damageHER2 amplificationTherapeutic strategiesTumor xenografts
2020
A DNA Repair Inhibitor Isolated from an Ecuadorian Fungal Endophyte Exhibits Synthetic Lethality in PTEN-Deficient Glioblastoma
Adaku N, Park HB, Spakowicz DJ, Tiwari MK, Strobel SA, Crawford JM, Rogers FA. A DNA Repair Inhibitor Isolated from an Ecuadorian Fungal Endophyte Exhibits Synthetic Lethality in PTEN-Deficient Glioblastoma. Journal Of Natural Products 2020, 83: 1899-1908. PMID: 32407116, DOI: 10.1021/acs.jnatprod.0c00012.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPTEN-deficient glioblastoma cellsPTEN-deficient cancersTumor suppressor PTENImportant molecular toolPTEN-deficient glioblastomaInhibitor of DNAHuman cancer developmentDNA repair inhibitorsFungal endophytesBreak repairGenomic levelSuppressor PTENMolecular toolsEndophytic fungiSynthetic lethalityPTEN deficiencyGlioblastoma cellsRepair inhibitorsCancer developmentPTEN lossCurrent cancer treatmentsLarger patient populationTherapeutic leadsMedicinal plantsNew therapeutic leads
2016
Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cells
Tiwari M, Adaku N, Peart N, Rogers FA. Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cells. Nucleic Acids Research 2016, 44: 7742-7754. PMID: 27298253, PMCID: PMC5027492, DOI: 10.1093/nar/gkw515.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDouble-strand breaksReplication fork collapseFork collapseGenomic instabilityReplication-associated double-strand breaksDNA replication fork progressionNucleotide excision repair proteinsTriplex structureRobust DNA damage responseDNA double-strand breaksReplication fork progressionReplication fork stabilityStrand breaksReplication fork integrityXPC-deficient cellsDNA damage responseMirror repeat sequencesExcision repair proteinsMore DSBsNER-deficient cellsDamage recognition proteinsGenomic integrityDual phosphorylationFork stabilityFork integrityImaging Functional Nucleic Acid Delivery to Skin
Kaspar RL, Hickerson RP, González-González E, Flores MA, Speaker TP, Rogers FA, Milstone LM, Contag CH. Imaging Functional Nucleic Acid Delivery to Skin. Methods In Molecular Biology 2016, 1372: 1-24. PMID: 26530911, DOI: 10.1007/978-1-4939-3148-4_1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNucleic acid deliveryNucleic acid-based therapiesAcid deliveryAcid-based therapiesFunctional deliveryFunctional nucleic acid deliveryTherapeutic nucleic acidsNucleic acidsOptical imaging technologiesReal-time monitoringTriplex nucleic acidsInteraction of lightMonogenic skin diseasesLight-tissue interactionsGene editingGene silencingOptical imagingNoninvasive imaging technologyTopical deliveryTime monitoringImaging technologyReporter geneLayered structureGeneral strategyEnzymatic reactions
2014
Improved bioactivity of G-rich triplex-forming oligonucleotides containing modified guanine bases
Rogers FA, Lloyd JA, Tiwari MK. Improved bioactivity of G-rich triplex-forming oligonucleotides containing modified guanine bases. Artificial DNA PNA & XNA 2014, 5: e27792. PMID: 25483840, PMCID: PMC4014521, DOI: 10.4161/adna.27792.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMobility gel shift assaysDNA double-strand breaksTarget sequenceGel shift assaysDouble-strand breaksGene-targeted mutagenesisActivation of apoptosisG-quadruplex formationGenomic modificationsDNA repairShift assaysReporter geneMolecular mechanismsPolypurine sequenceStrand breaksTriplex technologyTarget siteMutagenesisTriplex structureGenesGuanine baseTriplex formationGuanine basesSequenceAG30
Academic Achievements & Community Involvement
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Honors
honor Leadership in Diversity, Equity & Inclusion Award
03/24/2022Yale School of Medicine AwardYale Cancer CenterDetailsUnited Stateshonor Translational Science Research Prize
03/24/2022Yale School of Medicine AwardYale Cancer CenterDetailsUnited States
News & Links
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Media
Cellular Damage, Repair & Apoptosis - The Rogers Lab at Yale School of Medicine
A video about Dr. Rogers' research into cellular response to DNA damage in cancer.
News
- October 13, 2025
Biomedical Summer Undergraduate Research Fellowship Symposium 2025
- October 07, 2025
Multi-Day Cancer Symposium Lays Groundwork for Research Collaboration
- April 02, 2025
Yale Cancer Center Annual Awards
- August 16, 2024
Biomedical Summer Undergraduate Research Fellowship Symposium 2024
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Mailing Address
Therapeutic Radiology
PO Box 208040
New Haven, CT 06520-8040
United States
Locations
Hunter Building
Academic Office
15 York Street, Ste 213B
New Haven, CT 06510
Appointments
203.737.3658Fax
203.785.6309