Alisa Rybkin, MD, MPH
Assistant Professor of Therapeutic RadiologyCards
About
Research
Publications
2025
Will adaptive radiation therapy be the new state-of-the-ART in head and neck cancer?
Rybkin A, Young M, Park H. Will adaptive radiation therapy be the new state-of-the-ART in head and neck cancer? Journal Of The National Cancer Institute 2025, 118: 1-3. PMID: 41066140, DOI: 10.1093/jnci/djaf283.Commentaries, Editorials and LettersThis editorial contextualizes data on adaptive radiation therapy for head and neck cancer, showing potential to reduce side effects like xerostomia while maintaining effective tumor control.Evaluation of a Novel Prognostic System for Surgically Resected Oral Cavity Carcinoma
Rybkin A, Lee V, Young M, Eskander A, Burtness B, Park H, Husain Z. Evaluation of a Novel Prognostic System for Surgically Resected Oral Cavity Carcinoma. Head & Neck 2025, 48: 175-183. PMID: 40862436, DOI: 10.1002/hed.70022.Peer-Reviewed Original ResearchOral cavity carcinomaNational Cancer Data BaseOverall survivalHigh-risk groupFive-year OSTreated with surgeryPredictive of OSKaplan-Meier methodHigh-risk categoryT/N stageNegative marginsDefinitive surgeryDistant metastasisPatientsPrognostic systemCarcinomaSurgeryPrediction scoreLVSIMetastasisSurgicallyT/NCohortPoint-based systemOrally
2022
Outcomes for Organ Preservation with Chemoradiation Therapy for T4 Larynx and Hypopharynx Cancer
Eita A, Mohamed N, Rybkin A, Kang J, Fiasconaro M, Zhigang Z, Zakeri K, Yu Y, Sadaka E, Sherman E, Dunn L, Cracchiolo J, Wong R, Cohen M, Lee N. Outcomes for Organ Preservation with Chemoradiation Therapy for T4 Larynx and Hypopharynx Cancer. The Laryngoscope 2022, 133: 1138-1145. PMID: 35801573, PMCID: PMC10547133, DOI: 10.1002/lary.30279.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUnivariate analysisLocoregional failureT4 laryngealNonoperative managementHypopharyngeal cancerRadiation therapyPercutaneous endoscopic gastrostomy tubeHypopharynx cancer patientsYear OS ratesDisease-free survivalNon-surgical managementHypopharynx groupsInoperable diseaseLast followUnresectable diseaseChemoradiation therapyNodal statusGastrostomy tubeHypopharynx cancerOS ratesStage T4Cancer patientsFunctional outcomeTracheostomy tubeOrgan preservation
2021
The effect of short radiation treatment breaks on chemo‐radiotherapy for oropharyngeal cancers
Rybkin A, Kang JJ, Lee A, Kitpanit S, Fan M, Mohamed N, Cartano O, Zakeri K, Gelblum D, Sherman E, Dunn L, Boyle J, Wong R, Chen L, Yu Y, McBride SM, Tsai CJ, Riaz N, Lee NY. The effect of short radiation treatment breaks on chemo‐radiotherapy for oropharyngeal cancers. Head & Neck 2021, 43: 3796-3809. PMID: 34585792, PMCID: PMC9414892, DOI: 10.1002/hed.26879.Peer-Reviewed Original ResearchConceptsRadiation treatment breaksOropharyngeal squamous cell carcinomaOverall treatment timeTreatment breaksClinical outcomesDefinitive concurrent chemoradiotherapySquamous cell carcinomaConcurrent chemoradiotherapyOPSCC patientsOropharyngeal cancerDisease failureCell carcinomaNeck cancerCancer recurrenceConsecutive cohortMultivariate analysisSignificant associationPatientsCancerFurther investigationProlongationDaysOutcomesNumerous studiesChemoradiotherapyAny day, split halfway: Flexibility in scheduling high‐dose cisplatin—A large retrospective review from a high‐volume cancer center
Kang JJ, Tchekmedyian V, Mohammed N, Rybkin A, Kitpanit S, Fan M, Wang H, Lobaugh SM, Zhang Z, Lee A, Chen L, Yu Y, Zakeri K, Gelblum DY, Riaz N, McBride SM, Tsai CJ, Cohen MA, Cracchiolo JR, Morris LG, Singh B, Patel S, Ganly I, Boyle JO, Wong RJ, Eng J, Zhi WI, Ng K, Ho AL, Dunn LA, Michel L, Fetten JV, Pfister DG, Lee NY, Sherman EJ. Any day, split halfway: Flexibility in scheduling high‐dose cisplatin—A large retrospective review from a high‐volume cancer center. International Journal Of Cancer 2021, 149: 139-148. PMID: 33586179, PMCID: PMC9380235, DOI: 10.1002/ijc.33518.Peer-Reviewed Original ResearchConceptsTotal cumulative doseHigh-dose cisplatinLocoregional failureOverall survivalOropharyngeal cancerDistant metastasisRegional failureHigh-volume cancer centerLocal failureAlternate dosing schedulesHuman papillomavirus (HPV) statusKarnofsky performance statusCooperative group trialsAdvanced oropharyngeal cancerLarge retrospective reviewStandard of careMultivariable regression modelsDefinitive chemoradiationInduction chemotherapyPerformance statusDosing schedulesTherapy startAdministration dayRetrospective reviewRenal toxicity
2020
The 3 Bs of cancer care amid the COVID‐19 pandemic crisis: “Be safe, be smart, be kind”—A multidisciplinary approach increasing the use of radiation and embracing telemedicine for head and neck cancer
Kang JJ, Wong RJ, Sherman EJ, Rybkin A, McBride SM, Riaz N, Tsai CJ, Yu Y, Chen L, Zakeri K, Gelblum DY, Gillespie EF, Cohen MA, Cracchiolo JR, Ganly I, Patel S, Singh B, Boyle JO, Roman BR, Morris LG, Shaha AR, Dunn LA, Ho AL, Fetten JV, Shah JP, Pfister DG, Lee NY. The 3 Bs of cancer care amid the COVID‐19 pandemic crisis: “Be safe, be smart, be kind”—A multidisciplinary approach increasing the use of radiation and embracing telemedicine for head and neck cancer. Cancer 2020, 126: 4092-4104. PMID: 32639615, PMCID: PMC7361524, DOI: 10.1002/cncr.33031.Peer-Reviewed Original ResearchConceptsSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2High-volume cancer centerRespiratory syndrome coronavirus 2Coronavirus disease 2019 (COVID-19) pandemicSyndrome coronavirus 2Neck cancer treatmentDisease 2019 pandemicPersonal protective equipmentPublic health directivesEndoscopic evaluationNonsurgical treatmentCancer CenterCoronavirus 2Cancer careNeck cancerHNC treatmentOropharyngeal tractUse of radiationFeasibility dataMultidisciplinary conferenceCancer treatmentProtective equipmentRadiation oncologyMultidisciplinary approach
2016
Proton beam radiation therapy results in significantly reduced toxicity compared with intensity-modulated radiation therapy for head and neck tumors that require ipsilateral radiation
Romesser P, Cahlon O, Scher E, Zhou Y, Berry S, Rybkin A, Sine K, Tang S, Sherman E, Wong R, Lee N. Proton beam radiation therapy results in significantly reduced toxicity compared with intensity-modulated radiation therapy for head and neck tumors that require ipsilateral radiation. Radiotherapy And Oncology 2016, 118: 286-292. PMID: 26867969, PMCID: PMC4980117, DOI: 10.1016/j.radonc.2015.12.008.Peer-Reviewed Original ResearchConceptsIntensity-modulated radiation therapyProton beam radiation therapyBeam radiation therapyRadiation therapyTissue sparingTreated with intensity-modulated radiation therapyCommon Terminology Criteria for Adverse Events versionIntensity-modulated radiation therapy plansNational Cancer Institute Common Terminology Criteria for Adverse Events versionAcute treatment-related toxicityRates of grade 2Head and neck tumorsCutaneous squamous cell carcinomaMaximum spinal cordAdverse Events versionTreatment-related toxicitySalivary gland cancerSquamous cell carcinomaHead and neckContralateral parotidIpsilateral irradiationIpsilateral radiationDosimetric advantagesNeck tumorsTarget delineation
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