Anna Marie Pyle

Sterling Professor of Molecular, Cellular, and Developmental Biology and Professor of Chemistry; Director, Division of Biological Sciences

Departments & Organizations

Molecular Virology: Virology Laboratories

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS) | Computational Biology and Bioinformatics | Molecular Cell Biology, Genetics and Development

Structural Biology

Center for RNA Science and Medicine

Office of Cooperative Research

Liver Center

Yale Cancer Center: Virus and Other Infection-associated Cancers


Anna Marie Pyle is the William Edward Gilbert Professor of Molecular, Cellular and Developmental Biology and Professor of Chemistry at Yale University.She has been a Howard Hughes Medical Institute Investigator since 1997.Dr. Pyle obtained her undergraduate degree in Chemistry from Princeton University and received her Ph.D. in Chemistry from Columbia University in 1990, where she worked with Professor Jacqueline K. Barton. Dr. Pyle was a postdoctoral fellow in the laboratory of Thomas Cech at the University of Colorado. Dr. Pyle formed her own research group in 1992 in the Department of Biochemistry and Molecular Biophysics at Columbia University Medical Center.In 2002, she moved to Yale University, where she leads a research group that specializes in structure and function of large RNA molecules and RNA remodeling enzymes.Dr. Pyle teaches the undergraduate Molecular Biology course at Yale and she is Chair of the Building Committee for the new Yale Biology Building.Dr. Pyle is the Chair of the MSFA Study Section at the NIH, and previously served as a permanent member on the MSFE, and MGB Study Sections.At Brookhaven National labs, she serves on the Science and Technology Steering Committee and on Beamline Advisory Teams at the NSLSII light source.Dr. Pyle is the Co-Editor of Methods in Enzymology and serves on the Editorial Board of the Journal of Molecular Biology.Dr. Pyle is the author of over 160 publications and has mentored more than 40 graduate students and postdocs.The Pyle laboratory uses a diverse set of biochemical techniques, including crystallography and enzymology, to understand the structural complexity of large RNA molecules. She pioneered the study of RNA helicase enzymes and other RNA-stimulated ATPases that serve as translocases, RNA remodeling enzymes and signaling enzymes in the cell.Her experimental work is complemented by efforts to develop new computational tools for modeling, analyzing and predicting RNA structure.

Education & Training

Postdoctoral Fellow University of Colorado

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Contact Info

Anna Marie Pyle
Mailing Address
PO Box 208103
219 Prospect Street

New Haven, CT 06520-8103

Curriculum Vitae

Pyle Lab

Figure 2

Crystal structure of RIG-I in complex with RNA hairpin and Adenosine Diphosphate (top and side view, 4AY2). The color-coded key to domain organization is shown in the cartoon, below. RNA is yellow; ADP is pink. Hel1 and Hel2 are the conserved motor domains. The Pincer (P), Hel2i, and CTD are mechanical adapter domains. CARD1 and CARD2 are signaling domains. David Rawling

Figure 1

Crystal structure of the Oi group IIC intron (left, 4FAR). Homology model of the yeast group IIB ai5γ ( (right). The catalytic center (domain 5) is shown in red, surrounded by intron domains (gray). The ai5γ model was built using the Oi core, biochemical constraints, and the RCrane modeling program. Srinivas Somarowthu