Yu Sun
Associate Research Scientist in NeuroscienceCards
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Research
Publications
2025
A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement
Consortium A, Fu X, Wang S, Wu Y, Sun Y, Liu W, Xi X, Li G, Liu K, Yuan W, Chen F, Wang H, Yang T, Liu Y, Zheng J, Shi H, Qu J, Chen X, Suo L, Huang Y, Xu X, Tang X, Li X, Xu L, Gao X, Yu L, Shu Y, Zhang W, Sun J, Yuan H, Gong S, Li W, Ma X, Zha D, Gao J, Li H, He Z, Liu G, Pei G, Kong W, Wang H, Chai R. A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement. Life Medicine 2025, lnaf011. DOI: 10.1093/lifemedi/lnaf011.Peer-Reviewed Original ResearchAuditory healthAuditory systemAssociated with cognitive declineQuality of lifeHearing lossOlder adultsPsychosocial disordersSensory impairmentElderly populationConsensus statementCognitive declineHearingHealthAging societyVerbal communicationAgeSensory functionAbstract HearingHumoral biomarkersBiomarkers ConsortiumBiomarkersInterventionAging biomarkersAdultsComprehensive evaluationA positron emission tomography tracer for the imaging of oxidative stress in the central nervous system
Wilde J, Sun Y, Simpson S, Hill E, Fu Z, Bian E, Kinkaid M, Villanueva P, Weybright A, Terrell W, Qureshi Z, Perera S, Sheppard H, Stone J, Kundu B, Kuan C, Neumann K. A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system. Nature Biomedical Engineering 2025, 1-14. PMID: 40044816, DOI: 10.1038/s41551-025-01362-3.Peer-Reviewed Original ResearchCentral nervous systemPositron emission tomographyInjection of sodium nitroprussideOxidative stressNervous systemClinical trials of antioxidantsMiddle cerebral arteryBlood-brain barrierTrials of antioxidantsPositron emission tomography tracersIntrastriatal injectionParametric mappingSodium nitroprussideCerebral arteryLongitudinally in vivoIn vivo quantificationQuantification of oxidative stressEmission tomographyPET imagingAntioxidant edaravoneDynamic PET imagesHuman plasmaA force-sensitive adhesion GPCR is required for equilibrioception
Yang Z, Zhou S, Zhang Q, Song Z, Liu W, Sun Y, Wang M, Fu X, Zhu K, Guan Y, Qi J, Wang X, Sun Y, Lu Y, Ping Y, Xi Y, Teng Z, Xu L, Xiao P, Xu Z, Xiong W, Qin W, Yang W, Yi F, Chai R, Yu X, Sun J. A force-sensitive adhesion GPCR is required for equilibrioception. Cell Research 2025, 1-22. PMID: 39966628, DOI: 10.1038/s41422-025-01075-x.Peer-Reviewed Original ResearchTransmembrane channel-like protein 1G protein-coupled receptorsUtricular hair cellsHair cellsIncreased open probabilityAdhesion GPCRsVestibular hair cellsGlutamate releaseOpen probabilityApical membraneMET responsesVestibular functionCalcium signalingApical surfaceProtein 1Lphn2Heterologous systemsMechanosensitive G-protein-coupled receptorsMetSMiceFunctional analysisCellsMicroglia modulate the cerebrovascular reactivity through ectonucleotidase CD39
Fu Z, Ganesana M, Hwang P, Tan X, Kinkaid M, Sun Y, Bian E, Weybright A, Chen H, Sol-Church K, Eyo U, Pridans C, Quintana F, Robson S, Kumar P, Venton B, Schaefer A, Kuan C. Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39. Nature Communications 2025, 16: 956. PMID: 39843911, PMCID: PMC11754601, DOI: 10.1038/s41467-025-56093-5.Peer-Reviewed Original ResearchConceptsCerebral blood flowEctonucleotidases CD39Whisker stimulationResponse to whisker stimulationCerebrovascular reactivityDeletion of CD39Blood flowInjection of adenosine triphosphateModulation of cerebral blood flowRegulation of cerebral blood flowExtracellular adenosine triphosphateInjection of adenosineBorder-associated macrophagesMicroglia repopulationExtracellular adenosineAdenosine triphosphateFemale miceBlood flow anomaliesP2RY12 receptorCo-transmitterMouse modelPharmacological inhibitionCD39MicrogliaMiceMiMeJF: Application of Coupled Matrix and Tensor Factorization (CMTF) for Enhanced Microbiome-Metabolome Multi-Omic Analysis
Ou Z, Fu X, Norbäck D, Lin R, Wen J, Sun Y. MiMeJF: Application of Coupled Matrix and Tensor Factorization (CMTF) for Enhanced Microbiome-Metabolome Multi-Omic Analysis. Metabolites 2025, 15: 51. PMID: 39852393, PMCID: PMC11767930, DOI: 10.3390/metabo15010051.Peer-Reviewed Original ResearchJoint analysis of microbiomeHuman gut samplesIntegration of microbiomeAnalysis of microbiomeMulti-omics datasetsBiologically meaningful biomarkersBiologically relevant insightsMulti-omics analysisMulti-omics integrationMetabolomics dataMicrobial taxaPathway abundanceGut samplesFunctional pathwaysBiological processesInflammatory bowel diseaseMicrobiomeBiomarker identificationBiologyPyroglutamic acidTaxaJoint analysisMetabolomicsBiomarker detectionAbundanceEnvironmental impacts on childhood rhinitis: The role of green spaces, air pollutants, and indoor microbial communities in Taiyuan, a city in Northern China
Yang L, Gao H, Wang Y, Norbäck D, Zhao Z, Fu X, Sun Y, Zhang X. Environmental impacts on childhood rhinitis: The role of green spaces, air pollutants, and indoor microbial communities in Taiyuan, a city in Northern China. Ecotoxicology And Environmental Safety 2025, 289: 117662. PMID: 39756177, DOI: 10.1016/j.ecoenv.2024.117662.Peer-Reviewed Original ResearchConceptsAir pollutionGreen spacesEnhanced vegetation indexNormalized Difference Vegetation IndexIndoor microbiomeLevels of air pollutionAmbient air pollutionDay care centersCurrent rhinitisLand cover dataNorthern city of ChinaIndoor microbial communitiesVegetation indexBacterial 16S rRNASurrounding green spaceAssociated with current rhinitisCare centerGrassland proportionEnvironmental factorsNatural grasslandsInfluence respiratory healthAmplicon sequencingEnvironmental impactPollutionDifference Vegetation Index
2024
Nasal, dermal, oral and indoor dust microbe and their interrelationship in children with allergic rhinitis
Tang H, Du S, Niu Z, Zhang D, Tang Z, Chen H, Chen Z, Zhang M, Xu Y, Sun Y, Fu X, Norback D, Shao J, Zhao Z. Nasal, dermal, oral and indoor dust microbe and their interrelationship in children with allergic rhinitis. BMC Microbiology 2024, 24: 505. PMID: 39614169, PMCID: PMC11606197, DOI: 10.1186/s12866-024-03668-9.Peer-Reviewed Original ResearchConceptsSpecies levelBacterial speciesAR childrenNasal cavityMethodsIn this case–control studyBody sitesControl groupBacterial diversityCase-control studyB-diversityOral swab samplesS. epidermidisStaphylococcus epidermidisStaphylococcus aureusBacterial characterizationMicrobesAllergic rhinitisSpeciesHealthy subjectsBackgroundAllergic rhinitisSwab samplesHealthy onesConclusionsOur studyMicroorganismsRhinitisIntrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis
Cheng H, Chen N, Chen W, Wu Z, Sun Y, Teng W, Su F, Sung C, Wen Z. Intrathecal lactate dehydrogenase A inhibitors FX11 and oxamate alleviate chronic constriction injury-induced nociceptive sensitization through neuroinflammation and angiogenesis. The Journal Of Headache And Pain 2024, 25: 207. PMID: 39587478, PMCID: PMC11590346, DOI: 10.1186/s10194-024-01916-x.Peer-Reviewed Original ResearchConceptsLactate dehydrogenase ANeuropathic painNociceptive sensitizationLDHA inhibitorsTreat neuropathic painType of painUpregulation of glycolysisCCI-induced neuroinflammationCentral nervous systemBackgroundNeuropathic painNeuropathic ratsSpinal roleNociceptive behaviorBlood vessel growthImmunohistochemical analysisControl inflammationPainEffective treatmentConclusionIn conclusionHIF-1aCellular mechanismsNervous systemTherapeutic targetVessel growthWestern blottingExploring the role of genetics, gut microbiota and blood metabolites in IBD
Yuan Y, Fu X, Deng Y, Sun Y. Exploring the role of genetics, gut microbiota and blood metabolites in IBD. Gut 2024, 74: gutjnl-2024-333611. PMID: 39366724, DOI: 10.1136/gutjnl-2024-333611.Peer-Reviewed Original ResearchSynergistic effect of molecular sieving and adsorption inhibition in MOF-based mixed matrix membranes for efficient O2/N2 separation
Qin Z, Sun Y, Zhang Z, Zhang C, Tang C, Geng C, Qiao Z. Synergistic effect of molecular sieving and adsorption inhibition in MOF-based mixed matrix membranes for efficient O2/N2 separation. Chemical Engineering Journal 2024, 497: 154615. DOI: 10.1016/j.cej.2024.154615.Peer-Reviewed Original ResearchO-carboraneO2/N2 selectivityO2/N2 separationZIF-8Molecular sievesMOF-based mixed matrix membranesPolymers of intrinsic microporosityO2 permeabilitySurface of ZIF-8MOF-based membranesMixed matrix membranesEffect of molecular sievesPolymer-filler interfaceSynergistic effectIntrinsic microporosityN2 moleculesUpper bound limitMatrix membranesInterfacial compatibilityOptimized membraneO2/N2Pim-1Preferential adsorptionMembrane moduleAir separation
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