2013
J. T. P. Liggins et al.
Liggins JT, Yoo AJ, Mishra NK, Wheeler HM, Straka M, Leslie‐Mazwi T, Chaudhry ZA, Kemp S, Mlynash M, Bammer R, Albers GW, Lansberg MG, Investigators D. J. T. P. Liggins et al. International Journal Of Stroke 2013, 10: 705-709. PMID: 24207136, PMCID: PMC4048330, DOI: 10.1111/ijs.12207.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingBrain IschemiaCohort StudiesDatabases, FactualDiffusion Magnetic Resonance ImagingFemaleFibrinolytic AgentsHumansLogistic ModelsMaleMiddle AgedMulticenter Studies as TopicOutcome Assessment, Health CareSeverity of Illness IndexStrokeTissue Plasminogen ActivatorTreatment OutcomeConceptsPoor functional outcomeDiffusion-weighted imaging scoreFunctional outcomeImaging scoresTherapy scoreClinical responseDiffusion-weighted imaging volumeModified Rankin Scale scoreAcute stroke interventionAcute ischemic strokePercentage of patientsPredictive scoring systemRankin Scale scorePredictors of outcomeCharacteristic curveDiffusion-Weighted ImagingIschemic strokeEndovascular therapyIndependent predictorsPatient ageStroke interventionEndovascular treatmentValidation cohortClinical variablesLesion volumeThrombolysis in Stroke Despite Contraindications or Warnings?
Frank B, Grotta JC, Alexandrov AV, Bluhmki E, Lyden P, Meretoja A, Mishra NK, Shuaib A, Wahlgren NG, Weimar C, Lees KR. Thrombolysis in Stroke Despite Contraindications or Warnings? Stroke 2013, 44: 727-733. PMID: 23391774, DOI: 10.1161/strokeaha.112.674622.Peer-Reviewed Original ResearchConceptsHealth Stroke ScoreAlteplase treatmentStroke ScoreOdds ratioBaseline National InstitutesIntravenous alteplase treatmentPretreatment National InstitutesSingle antiplatelet agentTrial selection criteriaAcute ischemic strokeIschemic stroke patientsProportional odds logistic regression analysisSubgroup of patientsAdjusted odds ratioCommon clinical situationsNational InstituteLogistic regression analysisInternational normalizedIntravenous thrombolysisOral anticoagulationPrior strokeComprehensive retrospective analysisIschemic strokeRankin ScaleUntreated patients
2011
Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus
Mishra NK, Ahmed N, Davalos A, Iversen HK, Melo T, Soinne L, Wahlgren N, Lees KR. Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus. Neurology 2011, 77: 1866-1872. PMID: 22094479, DOI: 10.1212/wnl.0b013e318238ee42.Peer-Reviewed Original ResearchConceptsNIH Stroke Scale scoreBaseline NIH Stroke Scale scoreConcomitant diabetes mellitusPrior strokeIschemic stroke patientsDiabetes mellitusThrombolytic therapyStroke patientsOdds ratioScale scoreAcute ischemic stroke patientsInfluence of DMOutcomes of patientsStroke Scale scoreRankin Scale scoreConfidence intervalsDistribution of mRSAlteplase treatmentProportional odds logistic regressionMRS outcomesThrombolysis outcomesPatientsHaenszel testEuropean approvalCochran-Mantel
2010
Influence of Age on Outcome From Thrombolysis in Acute Stroke
Mishra NK, Diener HC, Lyden PD, Bluhmki E, Lees KR. Influence of Age on Outcome From Thrombolysis in Acute Stroke. Stroke 2010, 41: 2840-2848. PMID: 21030710, DOI: 10.1161/strokeaha.110.586206.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeHealth scale scoresControl subjectsIschemic strokeInfluence of ageScale scoreBaseline National InstitutesRankin Scale scoreNational InstituteLimited trial dataNeuroprotection trialsRankin scoreThrombolysis treatmentAcute strokeYounger patientsAge decilesPoor outcomeBaseline severityImproved outcomesPatientsHaenszel testTrial dataCochran-MantelThrombolysisLogistic regressionThrombolysis Is Associated With Consistent Functional Improvement Across Baseline Stroke Severity
Mishra NK, Lyden P, Grotta JC, Lees KR. Thrombolysis Is Associated With Consistent Functional Improvement Across Baseline Stroke Severity. Stroke 2010, 41: 2612-2617. PMID: 20947852, DOI: 10.1161/strokeaha.110.589317.Peer-Reviewed Original ResearchConceptsRankin Scale score distributionBaseline stroke severityBaseline NIHSSAssociation of treatmentScale score distributionStroke severityOdds ratioModified Rankin scale score distributionCochran-MantelVirtual International Stroke Trials ArchiveBaseline National InstitutesConsistent functional improvementsHealth Stroke ScaleProportional odds logistic regression analysisClinical trial enrollmentLogistic regression analysisNeuroprotection trialsUntreated comparatorsStroke ScaleTrial enrollmentAdjusted outcomesThrombolysed patientsNonrandomized comparisonBaseline severityFunctional improvement