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Peru

Site Institution 1: Universidad Peruana Cayetano Heredia (UPCH)

Site Institution: Universidad Peruana Cayetano Heredia (UPCH), ), Laboratorios de Investigación y Desarrollos
Research Areas: Malaria, Leptospirosis, Leishmaniasis, Hepatitis B, Parasitic Diseases, Immunology, Molecular Biology

Site Description:
The Laboratorios de Investigación y Desarrollos (LID) contributes to the scientific and technological progress of Peru through its state-of-the-art facilities that support cutting edge research and innovation.

Dr. Vinetz has worked in Peru since 1998, studying leptospirosis and malaria. Dr. Vinetz maintains a laboratory on the UPCH Faculty of Sciences campus (LID) and a fully functioning field laboratory. Dr. Gamboa leads the Malaria Research Group at LID-UPCH. This group has three independent laboratories that are the most modern facilities of their kind in Peru (outside of government). Facilities at LID include laboratories for molecular/cellular biology, bioinformatics and immunology. The Malaria Research Group also has laboratory facilities in Iquitos, which houses an insectary specialized in rearing mosquito species involved in malaria transmission. Drs. Vinetz and Gamboa have been collaborators for over 14 years. Together, they manage the Amazonian International Center of Excellence in Malaria Research (ICEMR), which focuses on utilizing a comprehensive approach to understanding the biological features of Amazonian malaria towards the ultimate goal of regional control and elimination of Plasmodium falciparum and P. vivax.

Current research projects and focus areas include:
  • Amazonian Center of Excellence in Malaria Research (Amazonia ICEMR)
    • Goals: To continue supporting the Amazonia ICEMR in its effort to discover underlying principles and develop new tools to go beyond conventional malaria control activities towards regional malaria elimination.
  • Translational Research Development for Endemic Infectious Diseases of Amazonia
    • Goals: To continue supporting the Global Infectious Disease Training program at UPCH, which aims to enhance tropical infectious disease research capacity in Peru by focusing on research disciplines and diseases relevant to the Amazon region of Peru.
  • Immunology of asympomatic malaria and the immunity effects in plasmodium transmission
  • Study of the fundamental biology of malaria resilience in the Amazon - characterize human populations of malaria transmission reservoirs (epidemiology), study the molecular ecology and transmission biology of human-Anopheles interactions, and investigate molecular and cellular mechanisms of non-sterilizing clinical immunity to malaria caused by P. vivax and P. falciparum.
  • Leptospira and Leptospirosis – collaboration of multidisciplinary studies of Leptospira and leptospirosis, focused on clinical field studies of acute undifferentiated febrile illness to characterize epidemiological and clinical features of leptospirosis and ultimately deploy new novel molecular and point-of-care diagnostic tests.

Site Institution 2: School of Public Health and Administration (FASPA)

Site Institution: Universidad Peruana Cayetano Heredia (UPCH), ), School of Public Health and Administration
Research Areas: HIV and Aging, Non-Communicable Diseases, Musculoskeletal Health, Osteoporosis, Sarcopenia

Site Description:
Peru is a country of enormous geographic, cultural and biologic diversity. Located in the capital city of Lima, the Universidad Peruana Cayetano Heredia (UPCH) is the leading biomedical teaching and research institution in the country. Since its foundation, UPCH´s scientific contributions have significantly influenced national public health policies and promoted development and innovation in Peru.

The newly remodeled School of Public Health (FASPA, acronym in Spanish), founded in 1998, is the only School of Public Health in Peru. Its mission is to generate, apply and disseminate knowledge relevant to health promotion, disease prevention and treatment in human populations. FASPA is committed to improving health management, health policies and health economics and considers research to be a key strategy to design effective policy and intervention programs.

Dr. Garcia has served as Dean of FASPA, Director of the Instituto Nacional de Salud (Peruvian National Institute of Health), and most recently as the Minister of Health of Peru. Dr. Hsieh is an Associate Professor at the Yale School of Medicine (Rheumatology) and School of Public Health (Chronic Disease Epidemiology). Her recent work focuses on prevention of osteoporosis and fractures in countries undergoing economic transition, and the intersection between HIV and non-communicable disease.

Dr. Evelyn Hsieh and Dr. Garcia have collaborated on epidemiological, prevention and health services research projects related to women’s health topics including sexually transmitted infections, osteoporosis, and aging-related comorbidities among Peruvian women with HIV (osteoporosis, fractures, and sarcopenia). This site strives to expand knowledge in these key areas of health, which are understudied in Peru and across much of Latin America.

Current or recent projects include:
  • Musculoskeletal Outcomes among Women Aging with HIV in Peru
  • Health-Related Quality of Life among Women Aging with HIV and Peru
  • Capacity building for NCD care for the HIV positive population of Peru: a national assessment of knowledge and resources among HIV providers
  • Expanding the toolbox for prevention of sarcopenia and osteoporosis among Peruvian People with HIV: A validation study

Other features of this site include:
  • 8 active research units within FASPA which have contributed with countless studies on areas of critical relevance for Peru and Globally: such as sexuality, mental health, adolescent health, epidemiology, STIs and HIV-AIDS, HPV, biomedical informatics, indigenous health, environment and health and global health with a focus on social innovation, implementation research and moving from research to policy.
  • Interdisciplinary research teams linked to the School, the University and other affiliated institutions. The creation and development of inter- institutional projects has been a productive and increasingly important process and has fostered the consolidation of working groups and research units.
  • Longstanding experience in training both Peruvian and foreign scholars in global health and research methods through the delivery of short courses/electives in Global Health, a formal master’s degree program, and the innovative Fogarty Kuskaya post-doctoral global health fellowship program.

Mentors

  • Site Mentor

    Internal Medicine & Infectious Diseases Professor, School of Public Health, Unit of Epidemiology, STI and HIV, Cayetano Heredia University; Adjunct Professor, Department of Global Health, University of Washington; Adjunct Professor, School of Public Health at Tulane University; Adjunct Professor, School of Science and Engineering, Cayetano Heredia University

  • U.S. Mentor

    Associate Professor of Medicine (Rheumatology, Allergy & Immunology); Chief of Rheumatology, VA Connecticut Healthcare System; Associate Professor on Term, Chronic Disease Epidemiology; Network Lead, Yale Network for Global Non-Communicable Diseases (NGN); Associate Program Director, Global Health Equity Scholars Program; Program Director, CMB Global Health Fellowship Programs; Affiliated Faculty, Yale Institute for Global Health

GHES Alumni

  • Mr. Abdeen will spend his fellowship year at Universidad Peruana Cayetano Heredia in Lima, Peru under the mentorship of Patricia Garcia, MD, MPH, PhD, and Evelyn Hsieh, MD, PhD. His research will focus on risk factors and prevalence of hand osteoarthritis among patients with HIV. Mr. Abdeen is a third-year medical student at the Penn State College of Medicine. He aspires to become a holistic and culturally adept orthopedic surgeon that has the means to affect people in a multitude of ways. His faith, Islam, has been the main source of influence throughout his life. His career trajectory has been influenced by Drs. Fadia Kamal, John Elfar, and David Glazier.
  • Dr. Malca Hernandez spent his fellowship year at Universidad Peruana Cayetano Heredia (UPCH) in Lima under the mentorship of Patricia Garcia, PhD, MPH, MD and Evelyn Hsieh, PhD, MPH, MD. His research focused on exploring the interrelationships of aging expectations and quality of life, depression, stigma, and musculoskeletal health among middle-aged and older patients with HTV in Peru. Dr. Malca Hernandez received his medical degree from UPCH. He is a budding researcher whose career goal is to contribute to developing public health policies to reduce the impact of infectious and tropical diseases in Peru, South America, and globally. Also, he is interested in pursuing a Master of Global Health and maintaining the relationships formed at the NTH orientation and Yale in order to plan for future research collaborations.
  • Fellowship Site: Universidad Peruana Cayetano HerediaUS Institution: Yale UniversityProject Title: Prevention of Osteoporosis-Related Fractures Among HIV Positive Women in Peru: Assessment of Risk Scores, Knowledge and Health BeliefsAround the world, osteoporosis-related fractures cause significant morbidity and mortality. Patients with HIV are at increased risk for osteoporosis and fractures due to a combination of traditional risk factors, the nature of chronic infection, and antiretroviral therapy. Dual-energy x-ray absorptiometry (DXA) is the gold-standard technique to assess bone mineral density (BMD), the measure by which osteoporosis is diagnosed. Because it is often not economically or logistically practical to obtain DXA scans for all individuals of a certain age or gender, osteoporosis risk scores have been developed to assist clinical judgement and identify patients at highest risk so they can be referred for DXA screening. In countries like Peru, where DXA machines are not widely available, this targeted approach is particularly important.In the general population, several osteoporosis risk scores have been validated, however, none of these tools have been studied in HIV positive women in Latin America, and no literature exists on how they can be incorporated into osteoporosis prevention strategies for this population. To optimize the uptake of prevention strategies among women with HIV, understanding patient-oriented factors such as knowledge and health beliefs regarding osteoporosis is critically important. Approximately 1250 women receive care at the HIV clinic at Loayza Hospital in Lima, Peru. Our proposal will work with a cohort of HIV-positive women over the age of 50 years with previously collected BMD results to measure the performance characteristics (sensitivity, specificity, area under the receiver operating characteristic curve) of four validated osteoporosis risk scores (Osteorisk, SCORE, ORAI, OST). Patients returning for routine follow up to the HIV clinic will complete the osteoporosis knowledge test and osteoporosis health beliefs score. These surveys are theory-driven, validated tools for assessment of osteoporosis-related knowledge and health beliefs that have been used successfully among community-dwelling Peruvian women. The ultimate goal of our project is to provide valuable insight into how screening and prevention of osteoporosis may be optimized, within the resource practicalities of countries like Peru, for an HIV positive population.
  • Assistant Professor of Emergency Medicine; Global Health Fellow, Emergency Medicine

    Dr. Sanchez Rodriguez will spend her fellowship year at Universidad Peruana Cayetano Heredia Hospital in Lima, Peru under the mentorship of Patricia Garcia, MD, MPH, PhD, Evelyn Hsieh, MD, PhD, and Eleanor Reid MD, MSc, PhD. Her research will focus on assessing the needs and barriers to palliative care services in emergency department settings in Lima, Perú. Dr. Sanchez Rodriguez is an Emergency Medicine Physician at Yale University. She aspires to evaluate and implement strategies to improve palliative and end of life care in Emergency Medicine units in Latin America. Her largest influence stems from her experience as an Emergency Medicine Resident in her home, Puerto Rico. Limited resources and organization often hindered physician ability to provide comprehensive and sensible care to patients nearing their end of life.
  • Ms. Woodson spent her fellowship year at Universidad Peruana Cayetano Heredia (UPCH) in Lima under the mentorship of Magaly Blas, PhD, MD and Purnima Madhivanan, MBBS, MPH, PhD. Her research focused on exploring the sexual and reproductive health of adolescent women in vulnerable populations in the Amazon Basin. Ms. Woodson is a candidate in Epidemiology at the University of Arizona. She is currently a Fulbright Fogarty scholar in Peru working with the Universidad Peruana Cayetano Heredia (UPCH) and the organization, Mamas del Rio. Ms. Woodson hopes to use this knowledge to help inform programs within the Amazon Basin region to help reduce adolescent pregnancy and to promote greater gender equality around reproductive health issues.