2018
Time From Imaging to Endovascular Reperfusion Predicts Outcome in Acute Stroke
Tsai JP, Mlynash M, Christensen S, Kemp S, Kim S, Mishra NK, Federau C, Nogueira RG, Jovin TG, Devlin TG, Akhtar N, Yavagal DR, Bammer R, Straka M, Zaharchuk G, Marks MP, Albers GW, Lansberg MG. Time From Imaging to Endovascular Reperfusion Predicts Outcome in Acute Stroke. Stroke 2018, 49: 952-957. PMID: 29581341, PMCID: PMC5875452, DOI: 10.1161/strokeaha.117.018858.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAgedAngiography, Digital SubtractionCerebral AngiographyCohort StudiesEndovascular ProceduresFemaleHumansInfarction, Middle Cerebral ArteryMaleMiddle AgedPerfusion ImagingPrognosisRecovery of FunctionReperfusionStrokeThrombectomyTime-to-TreatmentTomography, X-Ray ComputedTreatment OutcomeConceptsTarget mismatch profileReperfusion timeFunctional independenceMismatch profileInfarct growthCTP scansLarger final infarct volumeTarget mismatch patientsAcute ischemic strokeCohort of patientsFinal infarct volumeTarget mismatchSuccessful endovascular reperfusionMismatch patientsEndovascular reperfusionInfarct volumeRadiological outcomesSuccessful reperfusionAcute strokeIschemic strokeRadiographic outcomesEndovascular therapyBaseline imagingMalignant profileTomographic perfusion
2016
Comparison of stroke volume evolution on diffusion-weighted imaging and fluid-attenuated inversion recovery following endovascular thrombectomy
Federau C, Christensen S, Mlynash M, Tsai J, Kim S, Zaharchuk G, Inoue M, Straka M, Mishra NK, Kemp S, Lansberg MG, Albers GW. Comparison of stroke volume evolution on diffusion-weighted imaging and fluid-attenuated inversion recovery following endovascular thrombectomy. International Journal Of Stroke 2016, 12: 510-518. PMID: 27811306, DOI: 10.1177/1747493016677985.Peer-Reviewed Original ResearchConceptsInfarct lesion volumeFluid-attenuated inversion recoveryDiffusion-weighted imagingLesion volumeEndovascular thrombectomyInversion recoveryDay 5Fluid-attenuated inversion recovery lesionsPost-stroke onsetDegree of reperfusionStroke lesion volumeFluid-attenuated inversion recovery imagesInversion recovery imagesInfarct volumeInfarct growthStroke onsetSymptom onsetLesion growthPatientsRecovery imagesInterquartile rangeThrombectomyProcedure images
2013
J. T. P. Liggins et al.
Liggins JT, Yoo AJ, Mishra NK, Wheeler HM, Straka M, Leslie‐Mazwi T, Chaudhry ZA, Kemp S, Mlynash M, Bammer R, Albers GW, Lansberg MG, Investigators D. J. T. P. Liggins et al. International Journal Of Stroke 2013, 10: 705-709. PMID: 24207136, PMCID: PMC4048330, DOI: 10.1111/ijs.12207.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingBrain IschemiaCohort StudiesDatabases, FactualDiffusion Magnetic Resonance ImagingFemaleFibrinolytic AgentsHumansLogistic ModelsMaleMiddle AgedMulticenter Studies as TopicOutcome Assessment, Health CareSeverity of Illness IndexStrokeTissue Plasminogen ActivatorTreatment OutcomeConceptsPoor functional outcomeDiffusion-weighted imaging scoreFunctional outcomeImaging scoresTherapy scoreClinical responseDiffusion-weighted imaging volumeModified Rankin Scale scoreAcute stroke interventionAcute ischemic strokePercentage of patientsPredictive scoring systemRankin Scale scorePredictors of outcomeCharacteristic curveDiffusion-Weighted ImagingIschemic strokeEndovascular therapyIndependent predictorsPatient ageStroke interventionEndovascular treatmentValidation cohortClinical variablesLesion volumePostthrombolysis outcomes in acute ischemic stroke patients of Asian race‐ethnicity
Mishra NK, Chan BP, Teoh H, Meng C, Lees KR, Chen C, Sharma VK, collaboration F. Postthrombolysis outcomes in acute ischemic stroke patients of Asian race‐ethnicity. International Journal Of Stroke 2013, 8: 95-99. PMID: 23490069, DOI: 10.1111/ijs.12012.Peer-Reviewed Original ResearchConceptsVirtual International Stroke Trials ArchiveThrombolytic therapyStroke patientsAsian patientsHealth Stroke Scale scorePropensity score-matched patientsAcute ischemic stroke patientsTissue plasminogen activator therapyAsian stroke patientsBaseline National InstitutesPropensity-matched cohortStroke Scale scoreIschemic stroke patientsProportional odds logistic regression analysisPlasminogen activator therapyNational University HospitalLogistic regression analysisNational InstituteRace-ethnic differencesNeurological outcomeRankin scoreThrombolyzed patientsPropensity matchingTertiary centerActivator therapy
2011
Home Time Is Extended in Patients With Ischemic Stroke Who Receive Thrombolytic Therapy
Mishra NK, Shuaib A, Lyden P, Diener HC, Grotta J, Davis S, Davalos A, Ashwood T, Wasiewski W, Lees KR. Home Time Is Extended in Patients With Ischemic Stroke Who Receive Thrombolytic Therapy. Stroke 2011, 42: 1046-1050. PMID: 21350199, DOI: 10.1161/strokeaha.110.601302.Peer-Reviewed Original ResearchConceptsHealth Stroke ScaleBaseline National InstitutesPresence of diabetesAcute stroke trialsStroke ScaleRankin ScaleBarthel IndexStroke trialsNational InstituteDay 90Use of alteplaseHome timeCountry of enrollmentLevel of consciousnessAlteplase useIschemic strokeStroke onsetIschemic lesionsThrombolytic therapyPatient enrollmentBaseline severityOrdinal logistic regressionTreatment responsivenessOutcome measuresAnalysis of covariance