2013
Influence of racial differences on outcomes after thrombolytic therapy in acute ischemic stroke
Mishra NK, Mandava P, Chen C, Grotta J, Lees KR, Kent TA, collaboration V. Influence of racial differences on outcomes after thrombolytic therapy in acute ischemic stroke. International Journal Of Stroke 2013, 9: 613-617. PMID: 24148895, DOI: 10.1111/ijs.12162.Peer-Reviewed Original ResearchConceptsTissue plasminogen activatorBaseline National InstitutesHealth Stroke ScaleNon-Caucasian patientsPlasminogen activatorStroke ScaleNational InstituteRace-EthnicityNon-thrombolysed patientsStroke III TrialRace-ethnicity groupsNeuroprotection trialsIII trialsDiabetes statusFunctional outcomeImproved outcomesPatientsNeurological disordersCaucasian populationDifferential responseEthnicity groupsOutcomesCaucasiansOddsTrials
2011
Low Body Temperature Does Not Compromise the Treatment Effect of Alteplase
Lees JS, Mishra NK, Saini M, Lyden PD, Shuaib A. Low Body Temperature Does Not Compromise the Treatment Effect of Alteplase. Stroke 2011, 42: 2618-2621. PMID: 21757664, DOI: 10.1161/strokeaha.110.611210.Peer-Reviewed Original ResearchConceptsBaseline body temperatureAcute ischemic strokeRankin Scale scoreIschemic strokeAlteplase treatmentBaseline severityBody temperatureScale scoreVirtual International Stroke Trials ArchiveRankin Scale distributionsBaseline National InstitutesHealth Stroke ScaleIschemic stroke modelTreatment effectsStroke ScaleThrombolytic therapyImproved outcomesTherapeutic effectTreatment responseStroke modelTreatment groupsAlteplaseCochran-MantelLow body temperatureStroke
2010
Influence of Age on Outcome From Thrombolysis in Acute Stroke
Mishra NK, Diener HC, Lyden PD, Bluhmki E, Lees KR. Influence of Age on Outcome From Thrombolysis in Acute Stroke. Stroke 2010, 41: 2840-2848. PMID: 21030710, DOI: 10.1161/strokeaha.110.586206.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeHealth scale scoresControl subjectsIschemic strokeInfluence of ageScale scoreBaseline National InstitutesRankin Scale scoreNational InstituteLimited trial dataNeuroprotection trialsRankin scoreThrombolysis treatmentAcute strokeYounger patientsAge decilesPoor outcomeBaseline severityImproved outcomesPatientsHaenszel testTrial dataCochran-MantelThrombolysisLogistic regression
2009
Mismatch-Based Delayed Thrombolysis
Mishra NK, Albers GW, Davis SM, Donnan GA, Furlan AJ, Hacke W, Lees KR. Mismatch-Based Delayed Thrombolysis. Stroke 2009, 41: e25-e33. PMID: 19926836, DOI: 10.1161/strokeaha.109.566869.Peer-Reviewed Original ResearchConceptsSymptomatic intracerebral hemorrhageIntracerebral hemorrhageFavorable outcomeMismatch patientsSuccessful reperfusionStroke onsetClinical outcomesClinical benefitRecanalization/reperfusionPhase III trialsFavorable clinical outcomeWeb of KnowledgeDelayed thrombolysisMismatch selectionThrombolysis trialsIII trialsRelevant trialsCase seriesRoutine careThrombolytic therapyClinical findingsClinical trialsImproved outcomesOdds ratioPretreatment imaging