Douglas Brackney
Assistant Clinical Professor of Epidemiology (Microbial Diseases)DownloadHi-Res Photo
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Assistant Clinical Professor of Epidemiology (Microbial Diseases)
Biography
Dr. Brackney is an Assistant Scientist at the Connecticut Agricultural Experiment Station and Adjunct Assistant Clinical Professor of Epidemiology. He received his degree in Microbiology, Immunology and Pathology from Colorado State University in 2007 with an emphasis in arbovirology and vector biology. After post-doctoral fellowships at the University of New Mexico and Colorado State University, he moved with his family to the New Haven area in 2014 to join the Experiment Station. His laboratory is interested in understanding the cellular and molecular mechanisms mediating arbovirus-mosquito midgut interactions in hopes of identifying critical factors that can be targeted for novel control interventions.
Appointments
Epidemiology of Microbial Diseases
Assistant Professor AdjunctPrimary
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Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Douglas Brackney's published research.
Publications Timeline
A big-picture view of Douglas Brackney's research output by year.
Philip Armstrong
7Publications
296Citations
Publications
2024
Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics
Johnson R, Stopard I, Byrne H, Armstrong P, Brackney D, Lambert B. Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics. PLOS Pathogens 2024, 20: e1011975. PMID: 38557892, PMCID: PMC11008821, DOI: 10.1371/journal.ppat.1011975.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBasal lamina layersInfection dynamicsYellow fever virusEpidemics of severe diseaseMidgut escape barrierDengue virusVirus population dynamicsAmount of virusEstablishment of infectionDose-dependentlyMosquito feeding behaviorDEN virusesExtrinsic incubation periodFever virusMidgut epitheliumBlood feedingFeeding eventsMidgutViral infection dynamicsZika virusAedes aegyptiCourse of infectionEscape barrierAedes albopictusIncubation periodCorrigendum: A mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons
Ma Q, Srivastav S, Gamez S, Dayama G, Feitosa-Suntheimer F, Patterson E, Johnson R, Matson E, Gold A, Brackney D, Connor J, Colpitts T, Hughes G, Rasgon J, Nolan T, Akbari O, Lau N. Corrigendum: A mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons. Genome Research 2024, 34: 160-160. PMID: 38326031, PMCID: PMC10903936, DOI: 10.1101/gr.278898.123.Peer-Reviewed Original ResearchAltmetric
2022
Generation of Multiple Arbovirus-like Particles Using a Rapid Recombinant Vaccinia Virus Expression Platform
Wang Y, Griffiths A, Brackney D, Verardi P. Generation of Multiple Arbovirus-like Particles Using a Rapid Recombinant Vaccinia Virus Expression Platform. Pathogens 2022, 11: 1505. PMID: 36558839, PMCID: PMC9785247, DOI: 10.3390/pathogens11121505.Peer-Reviewed Original ResearchCitationsAltmetricConceptsVirus-like particlesTransmission electron microscopyRecombinant vaccinia virus expression systemVirus expression systemExpression platformVaccinia virus expression systemElectron microscopyGenetic modificationVLP formationExpression systemNative virionsPlatformSignal sequenceCapsid geneParticlesGenesMicroscopyRe-emerging arbovirusHeartland virusWestern blotVLP secretionPurificationThrombocytopenia syndrome virusExpressionMayaro virus
2021
Vector competence of human-biting ticks Ixodes scapularis, Amblyomma americanum and Dermacentor variabilis for Powassan virus
Sharma R, Cozens D, Armstrong P, Brackney D. Vector competence of human-biting ticks Ixodes scapularis, Amblyomma americanum and Dermacentor variabilis for Powassan virus. Parasites & Vectors 2021, 14: 466. PMID: 34503550, PMCID: PMC8427896, DOI: 10.1186/s13071-021-04974-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNaïve miceBALB/c micePublic health threatViremic miceC micePowassan virusIxodes sppIxodes scapularisInfection statusConclusionsOur findingsMiceDermacentor variabilisHealth threatPOWVTransmission fociTick speciesPotential roleInfected nymphsCompetent vectorsVector competenceEpidemiologyHuman riskFuture studiesResultsThe resultsVirusEffective control of the motile stages of Amblyomma americanum and reduced Ehrlichia spp. prevalence in adults via permethrin treatment of white-tailed deer in coastal Connecticut, USA
Williams S, Stafford K, Linske M, Brackney D, LaBonte A, Stuber H, Cozens D. Effective control of the motile stages of Amblyomma americanum and reduced Ehrlichia spp. prevalence in adults via permethrin treatment of white-tailed deer in coastal Connecticut, USA. Ticks And Tick-borne Diseases 2021, 12: 101675. PMID: 33529986, DOI: 10.1016/j.ttbdis.2021.101675.Peer-Reviewed Original ResearchCitationsAltmetricA mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons
Ma Q, Srivastav SP, Gamez S, Dayama G, Feitosa-Suntheimer F, Patterson EI, Johnson RM, Matson EM, Gold AS, Brackney DE, Connor JH, Colpitts TM, Hughes GL, Rasgon JL, Nolan T, Akbari OS, Lau NC. A mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons. Genome Research 2021, 31: gr.265157.120. PMID: 33419731, PMCID: PMC7919454, DOI: 10.1101/gr.265157.120.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPIWI-interacting RNAsGenomic resourcesMosquito cell culturesSmall RNA regulatory pathwaysSmall RNA expression profilesPIWI pathway genesRNA regulatory pathwaysSatellite DNA repeatsSmall RNA profilesCapacity of mosquitoesRNA interference (RNAi) pathwayRNA expression profilesImportant mosquito speciesTransposon activityGenome integritySiRNA populationsDNA repeatsInterference pathwayCluster lociCell culturesEvolutionary dynamicsPathway genesRegulatory pathwaysMosquito cellsExpression profiles
2008
Aedes aegyptiuses RNA interference in defense against Sindbis virus infection
Campbell C, Keene K, Brackney D, Olson K, Blair C, Wilusz J, Foy B. Aedes aegyptiuses RNA interference in defense against Sindbis virus infection. BMC Microbiology 2008, 8: 47. PMID: 18366655, PMCID: PMC2278134, DOI: 10.1186/1471-2180-8-47.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsVirus-dependent mannerAgo2 protein levelsVirus-specific siRNAsAnti-viral defense mechanismProtein levelsSINV infectionRNAi componentsAnti-viral defenseRNAi pathwayRNAi responseBlood-fed controlsSmall RNAsDsRNA injectionRecombinant Sindbis virusRNA interferenceTranscript levelsSindbis virus infectionSINV RNAMost populationsStrand RNAPathway activitySINV replicationRNAVirus interactionsDefense mechanisms
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- August 15, 2020Source: Yale News
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Epidemiology of Microbial Diseases
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