Detection and Genotype of High-Risk Human Papillomavirus in Fine-Needle Aspirates of Patients With Metastatic Squamous Cell Carcinoma Is Helpful in Determining Tumor Origin
Baldassarri R, Aronberg R, Levi AW, Yarbrough WG, Kowalski D, Chhieng D. Detection and Genotype of High-Risk Human Papillomavirus in Fine-Needle Aspirates of Patients With Metastatic Squamous Cell Carcinoma Is Helpful in Determining Tumor Origin. American Journal Of Clinical Pathology 2015, 143: 694-700. PMID: 25873503, DOI: 10.1309/ajcpcza4pszcfhq4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsy, Fine-NeedleCarcinoma, Squamous CellFemaleGenotypeHead and Neck NeoplasmsHuman papillomavirus 16HumansLymphatic MetastasisMaleMiddle AgedPapillomaviridaePapillomavirus InfectionsSquamous Cell Carcinoma of Head and NeckConceptsSquamous cell carcinomaCobas 4800 systemRoche cobas 4800 systemMetastatic squamous cell carcinomaFine needle aspiratesHuman papillomavirusHR-HPVCell carcinomaHPV 16High-risk (HR) HPVSquamous cell carcinoma originatingHigh-risk human papillomavirusNeck squamous cell carcinomaHPV 16/18 genotypesHR-HPV testingHR-HPV detectionHR-HPV resultsCorresponding histologic specimensLeft parapharyngeal massElectronic health recordsCarcinoma originatingMediastinal lymphadenopathyNegative HNSCCProspective studyHistologic material