Clinical Research

The Department of Therapeutic Radiology has a strong interest in the pursuit of research in various forms. The following are clinically related research studies in the Department of Therapeutic Radiology. The listing is a partial sample and additional active Clinical Trials can be found through the Yale Cancer Center.

Novel Approaches to Radiosensitize K-Ras Mutant Tumor Cells

• Primary investigator-Bindra
• Therapeutic Trial-No
• Initiation date-8/12
• Completion date-open
• Funding source-N/A
  

High-Throughput Screening for Small Molecule Inhibitors of Rhabdomyosarcoma Viability

• Primary investigator-Bindra
• Therapeutic Trial-No
• Initiation date-8/12
• Completion date-open
• Funding source-N/A

Investigation of Tumor DNA in Blood as a Cancer Biomarker

• Primary investigator-Patel
• Therapeutic trial-No
• Initiation date-11/2009
• Completion date-open
• Funding source- ASTRO/Brozman Foundation/Yale Cancer Center

Molecular Determinants of Radiosensitivity in NSCLC

• Primary investigator-Contessa (Johung)
• Therapeutic trial-No
• Initiation date- 1/12
• Completion date-open
• Funding source-N/A

PET Imaging of EGFR in Tumors

• Primary investigator-Contessa
• Therapeutic trial-No
• Initiation date- 6/11
• Completion date-open
• Funding source-Kalimeris/Yale Center for Clinical Investigation

(Additional Therapeutic Trails can be found through the Yale Cancer Center)

SEER evaluation of gender, race, and outcomes for cutaneous lymphoma

• Primary investigator-Wilson
• Therapeutic trial-No
• Initiation date-7/11
• Completion date-open
• Funding source-NIH/Kalimeris

A Multicenter, Open-Label, Randomized, Phase I/II Study Evaluating the Safety and Efficacy of Low-Dose (12Gy) Total Skin Electron Beam Therapy (TSEBT) Combined With Vorinostat Versus Low-Dose TSEBT Monotherapy in Mycosis Fungoides (MF)

• Primary investigator-Wilson
• Therapeutic trial-yes
• Initiation date-3/24/11
• Completion date-open
• Funding source: Stanford university/MERCK
  

A Pilot Study of Four-Dimensional Conformal Image Guided Accelerated Partial Breast Irradiation in the treatment of stage 0 and I breast carcinoma

• Primary investigator-Evans
• Therapeutic trial-Yes
• Initiation date-1/2012
• Completion date-open
• Funding source-Cancer center

Dosimetric Predictors of Moist Desquamation in Breast Radiotherapy

• Primary Investigator- Evans
• Collaborators-Rutter, Higgins
• Therapeutic trial-no
• Initiation date-9/12
• Completion date-IRB pending
• Funding source-n/a
  

Predictors of Local Control in Inflammatory Breast Cancer

• Primary Investigator- Evans
• Collaborators-Taylor
• Therapeutic Trial-no
• Initiation date-9/12
• Completion date-IRB pending
• Funding source-n/a
  

Cost-Effectiveness Research and Radiation Oncology; An Analysis of the Existing Literature

• Primary investigator - Dosoretz
• Therapeutic trial-No
• Initiation date-7/12
• Completion date-open
• Funding source- n/a

Academic Career Selection in Radiation Oncology: A Survey Across Time and Institution

• Primary investigator - Dosoretz
• Therapeutic trial - no
• Initiation date - 3/12
• Completion date - open
• Funding Source - n/a

A Decision Analysis to Assess the Value of Prostate Cancer Screening: A Shift in Focus from Prostate Cancer Specific Mortality to Distant Metastasis Free Survival

• Primary investigator - Dosoretz
• Therapeutic trial - no
• Initiation date - 2/12
• Completion date - open
• Funding Source - n/a

Histopathology of Post-Radiosurgery Imaging Changes

• Primary investigator: Veronica Chiang
• Therapeutic trial: No
• Initiation date: 8/11
• Completion date: open
• Funding source: N/A

• Primary investigator: Joanne Weidhaas
• Therapeutic trial: Yes
• Initiation date: 05/06
• Completion date: open
  
• Funding source: Yale

Immediate DIEP Breast Reconstruction and Post-Mastectomy Radiotherapy: Clinical Experience

• Primary investigator: Susan Higgins
• Therapeutic trial: No
• Initiation date: 08/11
• Completion date: open
• Funding source: N/A

Chemotherapy and Intra-Vaginal Brachytherapy for Stage III Endometrial Cancer

• Primary investigator- Damast, Young
• Therapeutic trial- No
• Initiation date- 1/12
• Completion date- open
• Funding source- none

A comparison of three treatment strategies for locally advanced pancreatic cancer

• Primary investigator-Bryan Chang / Shane Lloyd
• Therapeutic trial-No
• Initiation date-3/12
• Completion date-open
• Funding source-none

The Funding of Phase 3 Clinical Trials Examining Radiation Compared with That of Other Modalities

• Primary investigator-James Yu / Shane Lloyd
• Therapeutic trial-No
• Initiation date-3/11
• Completion date-open
• Funding source-none

Stereotactic Radiosurgery for Older Cancer Patients with Early Stage Non-small Cell Lung Cancer: National Patterns of Care and Comparison with Surgery

• Primary investigator-Yu
• Therapeutic trial-No
• Initiation date-7/12
• Completion date-open
• Funding source-YCCI

Clinical, socioeconomic, and geographic correlates to outcomes from cancer care using multiple large cancer databases, including SEER, the AMA masterfile, and state cancer profiles

• Primary investigators-Yu, Aneja, Dosoretz, Park
• Therapeutic trial-No
• Initiation date-7/09
• Completion date-open
• Funding source-None

Clinical, socioeconomic, and geographic correlates to outcomes from cancer care using multiple large cancer databases

• Primary investigators-Yu, Lloyd
• ]Therapeutic trial-No
• Initiation date-7/09
• Completion date-open
• Funding source-None

Boost vs. No Boost for Ductal Carcinoma In-Situ: A Multi-Institutional Evaluation

• Primary investigator-Meena S. Moran
• Therapeutic trial-No, multi-institutional large retrospective cohort evaluating patients from MD Anderson, Dana Farber, William Beaumont, UPenn, UMDNJ, British Columbia and Yale Radiation Therapy Departments
• Initiation date- 2010
• Completion date-2013
• Funding source-Kalimeris

Racial Disparities Between African Americans and White Breast Cancer Veterans From The Veteran Affairs Central Registry Database

• Primary investigator: Meena S. Moran
• Therapeutic trial: No, evaluation of the VA National Database in collaboration with Creighton University and University of Nebraska
• Initiation date- 2010
• Completion date-8/2012
• Funding source-none

Is Ki-67 a marker for local relapse in women undergoing breast conservation therapy?

• Primary investigator: Meena S. Moran
• Therapeutic trial: No, tissue micro-array analysis
• Initiation date: 2010
• Completion date: Thesis project for Yale Med student graduating 2013
• Funding source: Kalimeris

Differences in Various Molecular Marker Over-Expression for Early-Stage Breast Cancer in African American and White Women

• Primary investigator: Meena S. Moran
• Therapeutic trial: No,
• Initiation date: 2012
• Completion date-open
• Funding source-none

A Randomized Study of Lymphedema Screening Using Clinical Measurements Alone vs. Bioimpedance + Clinical Measurements for the Detection and Prevention of Chronic Lymphedema

• Primary investigator: Meena S. Moran
• Therapeutic trial: No, but prospective, randomized clinical study
• Initiation date: 9/12
• Completion date-open
• Funding source-Backus Breast Foundation

Implementation and Utilization of Reflex Testing to Improve Time Lines in Breast Center Programs: A Prospective Study

• Primary investigator: Meena S. Moran
• Therapeutic trial: No, but prospective clinical study
• Initiation date-9/09
• Completion date-1 year
• Funding source-None

Evaluation of the positive predictive value of BIRADS

• Primary investigator: Meena S. Moran
• Therapeutic trial: No, but clinical study
• Initiation date-9/12-
• Completion date: 3 years-Yale Medical Student Thesis Project, graduating in 3 years
• Funding source-Yale School of Medicine

Hypofractionated Post-mastectomy Radiation Therapy

• Primary investigator: Meena S. Moran
• Therapeutic trial: Yes
• Initiation date-10/12
• Completion date-3 years
• Funding source-Pending, Gateway Corp.

Do women of African American Race have increased local relapse after breast conservation therapy? A Meta-Analysis of the Published Data

• Primary investigator: Meena S. Moran
• Therapeutic trial: Yes
• Initiation date-2012
• Completion date-open
• Funding source-None

Lung SBRT Database; including comparing biopsied vs. unbiopsied patients as well as multiple primary vs. single primary NSCLC

• Primary investigator-Decker
• Therapeutic trial-No
• Initiation date-1/2012
• Completion date-open Funding source-N/A