Alexander Van Slyke, PhD, DABR
Assistant Professor of Therapeutic RadiologyDownloadHi-Res Photo
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Therapeutic Radiology
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Assistant Professor of Therapeutic Radiology
Appointments
Therapeutic Radiology
Assistant ProfessorPrimary
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Education & Training
- Medical Physics Resident
- University of Maryland (2023)
- Postdoctoral Fellow
- University of Pennsylvania (2021)
- Non Degree Program
- University of Pennsylvania, Certificate in Medical Physics (2020)
- PhD
- Cornell University, Biophysics (2019)
- BA
- SUNY Geneseo, Physics and Mathematics (2012)
Board Certifications
Therapeutic Medical Physics
- Certification Organization
- American Board of Radiology
- Original Certification Date
- 2024
Research
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Research at a Glance
Publications Timeline
A big-picture view of Alexander Van Slyke's research output by year.
13Publications
124Citations
Publications
2025
Geometric characterization of an electromagnetic surface tracking system in a radiation therapy environment.
Soomro MH, Xu J, Ding J, Cammin J, Lamichhane N, Van Slyke A, Liang X, Roys S, Zhuo J, Ernst T, Gullapalli RP, Nevo E, Sawant A. Geometric characterization of an electromagnetic surface tracking system in a radiation therapy environment. J Appl Clin Med Phys 2025, 26: e70187. PMID: 40660872, DOI: 10.1002/acm2.70187.Peer-Reviewed Original Research
2023
An AI-based universal phantom analysis method based on XML-SVG wireframes with novel functional object identifiers
Sakaamini A, Van Slyke A, Partouche J, Wu T, Wiersma R. An AI-based universal phantom analysis method based on XML-SVG wireframes with novel functional object identifiers. Physics In Medicine And Biology 2023, 68: 145020. PMID: 37267994, PMCID: PMC10405228, DOI: 10.1088/1361-6560/acdb44.Peer-Reviewed Original Research
2022
Improving the efficiency of small animal 3D‐printed compensator IMRT with beamlet intensity total variation regularization
Liu X, Van Slyke A, Pearson E, Shoniyozov K, Redler G, Wiersma R. Improving the efficiency of small animal 3D‐printed compensator IMRT with beamlet intensity total variation regularization. Medical Physics 2022, 49: 5400-5408. PMID: 35608256, DOI: 10.1002/mp.15764.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsIntensity-modulated radiation therapyBeam-on timeBeamlet intensitiesLung plansGamma analysisClinical intensity-modulated radiation therapyIMRT methodsTotal massComposite doseFluence mapsDose conformityGantry angleCompensator thicknessComposite deliveryCompensated materialPlan compensatorsBeamletsIntensity mapsDose metricsPreclinical scaleRadiation therapyTotal variation regularizationMouse heartsAttenuation regionsLong delivery timesOxygen Monitoring in Model Solutions and In Vivo in Mice During Proton Irradiation at Conventional and FLASH Dose Rates
Van Slyke A, Khatib M, Velalopoulou A, Diffenderfer E, Shoniyozov K, Kim M, Karagounis I, Busch T, Vinogradov S, Koch C, Wiersma R. Oxygen Monitoring in Model Solutions and In Vivo in Mice During Proton Irradiation at Conventional and FLASH Dose Rates. Radiation Research 2022, 198: 181-189. PMID: 35640166, PMCID: PMC10176203, DOI: 10.1667/rade-21-00232.1.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsFLASH dose ratesConventional dose ratesDose rateProton irradiationDose deliveryG-valuesNormal tissue sparing effectAdvanced Markus chamberTissue sparing effectSarcoma tumorsIn vivoHigh-dose-rateMarkus chamberGamma raysFLASH effectRadiation deliveryRadiation dosimetryFLASH irradiationTumor controlRadiation therapyPO2 levelsTherapeutic ratioIn vivo oxygen measurementsMuscle in vivoTumor tissuesUltrafast Tracking of Oxygen Dynamics During Proton FLASH
El Khatib M, Van Slyke A, Velalopoulou A, Kim M, Shoniyozov K, Allu S, Diffenderfer E, Busch T, Wiersma R, Koch C, Vinogradov S. Ultrafast Tracking of Oxygen Dynamics During Proton FLASH. International Journal Of Radiation Oncology • Biology • Physics 2022, 113: 624-634. PMID: 35314293, PMCID: PMC9250619, DOI: 10.1016/j.ijrobp.2022.03.016.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFLASH effectProton FLASHFLASH-RTRadiation therapyConventional radiation therapyG-valuesIn vivoBaseline oxygen levelsIn vitroWell-oxygenated tissuesRadiobiological studiesConventional irradiationTherapeutic advantageDose rateNormal tissuesSevere hypoxiaPhosphorescence quenching methodTherapyOxygen-dependentDepletion of oxygenTissueSerum albuminDynamicsHypoxiaQuenching methodO048 FLASH Mechanisms Track (Oral Presentations) ULTRAFAST TRACKING OF OXYGEN DYNAMICS DURING PROTON FLASH
Khatib M, Van Slyke A, Velalopoulou A, Shoniyozov K, Diffenderfer E, Kim M, Karagounis I, Busch T, Wiersma R, Koch C, Vinogradov S. O048 FLASH Mechanisms Track (Oral Presentations) ULTRAFAST TRACKING OF OXYGEN DYNAMICS DURING PROTON FLASH. Physica Medica 2022, 94: s31. DOI: 10.1016/s1120-1797(22)01499-5.Peer-Reviewed Original Research
2021
Ultra-Fast Oxygen Monitoring During Proton FLASH Delivery Using the Phosphorescence Quenching Method and Soluble Oxyphor Probes
Van Slyke A, Khatib M, Shoniyozov K, Diffenderfer E, Kim M, Koch C, Vinogradov S, Wiersma R. Ultra-Fast Oxygen Monitoring During Proton FLASH Delivery Using the Phosphorescence Quenching Method and Soluble Oxyphor Probes. International Journal Of Radiation Oncology • Biology • Physics 2021, 111: s31-s32. DOI: 10.1016/j.ijrobp.2021.07.098.Peer-Reviewed Original ResearchCitations
2020
Stoichiometric analysis of protein complexes by cell fusion and single molecule imaging
Singh A, Van Slyke A, Sirenko M, Song A, Kammermeier P, Zipfel W. Stoichiometric analysis of protein complexes by cell fusion and single molecule imaging. Scientific Reports 2020, 10: 14866. PMID: 32913201, PMCID: PMC7483473, DOI: 10.1038/s41598-020-71630-6.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProtein complexesSubunit stoichiometrySingle molecule imagingAnalysis of protein complexesProtein complex stoichiometrySupramolecular protein complexesStoichiometric analysisMolecule imagingLow expression levelsSubunit interactionsBiological functionsComplex stoichiometryCellular environmentMembrane receptorsCell fusionSingle molecule levelDetergent isolationExpression levelsFluorescence correlation spectroscopyConcentration rangeProtein recoverySingle molecule measurementsSubunitStoichiometryMolecular interactions
2018
Investigating the Heteromerization of Metabotropic Glutamate Receptors using a Novel Single Molecule Imaging Method
Van Slyke A, Singth A, Deshmukh N, Kammermeier P, Zipfel W. Investigating the Heteromerization of Metabotropic Glutamate Receptors using a Novel Single Molecule Imaging Method. Biophysical Journal 2018, 114: 531a. DOI: 10.1016/j.bpj.2017.11.2903.Peer-Reviewed Original ResearchAltmetric
2016
Investigating the Kinetics and Specificity of Transcription Activator-Like Effector Binding using High Throughput Single Molecule Imaging
Van Slyke A, Singh A, Rinaldi F, Bogdanove A, Lis J, Zipfel W. Investigating the Kinetics and Specificity of Transcription Activator-Like Effector Binding using High Throughput Single Molecule Imaging. Biophysical Journal 2016, 110: 640a. DOI: 10.1016/j.bpj.2015.11.3427.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Activities
activity C-RAD Optimization Committee
2024 - PresentCommitteesActing Co-Chairactivity Feasibility of Real-Time Electromagnetic (EM) Surface Tracking Inside the Treatment Room
07/21/2024 - 07/25/2024Oral PresentationAAPM 66th Annual MeetingDetailsLos Angeles, CA, United StatesCollaborators- M Hussain SoomroUniversity of Maryland Medical Center
- Alexander Van Slyke, PhD, DABR
activity Lung SBRT Planning Committee
2024 - 2024CommitteesChairactivity A Simulation of the Effect of Intrafraction Motion on the Delivered Dose Distribution in LATTICE Radiation Therapy
09/30/2022 - 10/01/2022Oral PresentationMACAAPM 2022 Annual MeetingDetailsAnnapolis, MD, United StatesCollaboratorsactivity A Simulation of the Effect of Respiration-Induced Motion on the Delivered Dose Distribution in LATTICE Radiation Therapy
07/10/2022 - 07/14/2022Oral PresentationAAPM 64th Annual MeetingDetailsWashington, DC, United StatesCollaborators
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