Bong Ihn Koh
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About
Research
Overview
The bone marrow (BM) microenvironment is a critical regulator of hematopoietic stem cell self-renewal and fate. Aging, chronic inflammation and other insults compromise bone marrow function, but our current knowledge of the heterogeneity of various bones and their BM compartments in terms of endothelial, stromal and hematopoietic cell composition, as well as their hematopoietic function, is fairly limited.
The human skull is composed of 8 cranial and 14 facial bones. Whether distinct BM compartments within these bones are molecularly, cellularly and functionally specialized to perform specific immunological roles in general physiology is unknown. Furthermore, little is known whether the local and systemic impact of various pathologies, such as aging, neurodegenerative diseases and leukemia, affects various craniofacial bones and their BM compartments in a similar or distinct manner.
The overarching goal of the Koh Lab is to determine how distinct craniofacial tissue microenvironments confer functional specialization in health and disease. Using state-of-the-art imaging, transcriptomics/proteomics, and innovative functional assays, we will characterize unique cellular compositions and dynamic intercellular crosstalk in various craniofacial bone marrow compartments and meningeal interfaces during development, homeostasis and pathophysiological conditions. This work has the great potential to fundamentally impact the way we think about bone marrow heterogeneity and cranial tissue-specific immunological/physiological functions. Key findings from the Koh Lab may thus lead to novel therapeutic strategies against bone marrow aging, neurodegenerative diseases and leukemia.
Medical Research Interests
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Locations
Amistad Street Building
Academic Office
10 Amistad Street
New Haven, CT 06519
Amistad Street Building
Lab
10 Amistad Street
New Haven, CT 06519
Events
Yale Only Ömer H. Yilmaz, MD, PhD
Yale Only Aparna Bhaduri, PhD
Yale Only Matthew Greenblatt, MD, PhD
Yale Only Ulrich G. Steidl, MD, PhD