Craig M Crews, PhD

Lewis B. Cullman Professor of Molecular, Cellular, and Developmental Biology and Professor of Chemistry; Executive Director, Yale Center for Molecular Discovery

Research Interests

Biochemistry; Biology; Chemistry; Cell Biology; Neoplasms; Pharmacology; Drugs, Investigational; Proteasome Endopeptidase Complex; Proteasome Inhibitors

Research Organizations

Diabetes Research Center

Stem Cell Center, Yale

Yale Cancer Center: Developmental Therapeutics

Office of Cooperative Research

Research Summary

We use a combination of biochemistry, molecular biology, and bio-organic chemistry to explore different aspects of developmental and cell biology. Different projects include 1) the exploration of how biologically active compounds from nature work in order to identify new probes for cell biology as well as identify novel drug targets and 2) the development of novel small molecules to control intracellular protein homeostasis.

Extensive Research Description

We develop novel reagents, which will allow us to explore new areas in cell biology. This 'chemical genetic' approach uses biologically active natural products and de novo designed small molecules to identify critical components in intracellular processes. In the past few years, our efforts have focused on anti-angiogenic, antitumor and anti-inflammatory natural products. More recently, we have explored the use of small molecules to control intracellular protein levels, either by inhibiting their degradation or by inducing their proteolysis via the 26S proteasome. A goal of this research is to develop novel methodologies that would allow for small molecule control of the 'undruggable proteome'.

Selected Publications

Full List of PubMed Publications

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Contact Info

Craig M Crews, PhD
Mailing Address
Yale University
P.O. Box 208103

New Haven, CT 06520-8103

Curriculum Vitae

Crews Laboratory Homepage

PROTACs: Induced Protein Degradation as a New Pharmaceutical Paradigm

Since 2000, the Crews lab has focused on developing new methodologies for "Controlled Proteostasis" such as Proteolysis Targeting Chimeras (PROTACs), which are powerful inducers of protein degradation that remove unwanted proteins from cells.