Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity
Male A, Goudzwaard E, Nakahara S, Turner J, Calhoun V, Mueller B, Lim K, Bustillo J, Belger A, Voyvodic J, O'Leary D, Mathalon D, Ford J, Potkin S, Preda A, van Erp T. Structural white matter abnormalities in Schizophrenia and associations with neurocognitive performance and symptom severity. Psychiatry Research Neuroimaging 2024, 342: 111843. PMID: 38896909, DOI: 10.1016/j.pscychresns.2024.111843.Peer-Reviewed Original ResearchConceptsSymptom severityFractional anisotropyDiffusion tensor imagingNeurocognitive performanceCognitive performanceAssociated with speed of processingLeft inferior fronto-occipital fasciculusWM abnormalitiesAssociated with neurocognitive performancePathophysiology of schizophreniaCognitive performance deficitsInferior fronto-occipital fasciculusSpeed of processingStructural white matter abnormalitiesMean diffusivityAxial diffusivityFronto-occipital fasciculusHealthy controlsRadial diffusivityRegional WM abnormalitiesNegative symptomsPerformance deficitsWhite matterWhite matter abnormalitiesAssociated with speed