2020
Neuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease
Weintraub D, Caspell‐Garcia C, Simuni T, Cho HR, Coffey CS, Aarsland D, Alcalay RN, Barrett MJ, Chahine LM, Eberling J, Espay AJ, Hamilton J, Hawkins KA, Leverenz J, Litvan I, Richard I, Rosenthal LS, Siderowf A, York M, Initiative P. Neuropsychiatric symptoms and cognitive abilities over the initial quinquennium of Parkinson disease. Annals Of Clinical And Translational Neurology 2020, 7: 449-461. PMID: 32285645, PMCID: PMC7187707, DOI: 10.1002/acn3.51022.Peer-Reviewed Original ResearchConceptsParkinson's disease participantsNeuropsychiatric symptomsParkinson's diseaseHealthy controlsCognitive impairmentMedication useYear 5Anticholinergic medication useCross-sectional prevalenceParkinson's disease patientsHypnotic useDisease patientsNeuropsychiatric featuresDisease onsetAnnual visitsSymptomsDisorder subtypesAbsolute prevalenceDiseaseTime pointsPrevalenceBaselineImpairmentParticipantsOnset
2019
DEPRESSION PREDICTS DELIRIUM AFTER CORONARY ARTERY BYPASS GRAFT SURGERY INDEPENDENT OF COGNITIVE IMPAIRMENT AND CEREBROVASCULAR DISEASE: AN ANALYSIS OF THE NOAHS STUDY
Lin I, Oldham M, Hawkins K, Scoutt L, Yuh D, Lee H. DEPRESSION PREDICTS DELIRIUM AFTER CORONARY ARTERY BYPASS GRAFT SURGERY INDEPENDENT OF COGNITIVE IMPAIRMENT AND CEREBROVASCULAR DISEASE: AN ANALYSIS OF THE NOAHS STUDY. American Journal Of Geriatric Psychiatry 2019, 27: s160-s161. DOI: 10.1016/j.jagp.2019.01.113.Peer-Reviewed Original ResearchMiddle cerebral arteryMild cognitive impairmentCerebrovascular diseaseCognitive impairmentRisk factorsCoronary artery bypass graft surgeryStenosis severityArtery bypass graft surgeryBilateral middle cerebral arteriesPreoperative cognitive assessmentBypass graft surgeryConfusion Assessment MethodCoronary artery bypassRisk of deliriumDelirium risk factorsObservational cohort studyPostoperative day 2Clinical Dementia RatingPutative risk factorsResults Average ageCI 1.3Preoperative depressionStructured HamiltonStudy psychiatristArtery bypass
2018
Depression Predicts Delirium After Coronary Artery Bypass Graft Surgery Independent of Cognitive Impairment and Cerebrovascular Disease: An Analysis of the Neuropsychiatric Outcomes After Heart Surgery Study
Oldham MA, Hawkins KA, Lin IH, Deng Y, Hao Q, Scoutt LM, Yuh DD, Lee HB. Depression Predicts Delirium After Coronary Artery Bypass Graft Surgery Independent of Cognitive Impairment and Cerebrovascular Disease: An Analysis of the Neuropsychiatric Outcomes After Heart Surgery Study. American Journal Of Geriatric Psychiatry 2018, 27: 476-486. PMID: 30709616, PMCID: PMC6443412, DOI: 10.1016/j.jagp.2018.12.025.Peer-Reviewed Original ResearchConceptsMiddle cerebral arteryMild cognitive impairmentCerebrovascular diseaseCognitive impairmentRisk factorsCoronary artery bypass graft surgeryStenosis severityProspective observational cohort studyArtery bypass graft surgeryBilateral middle cerebral arteriesTertiary care academic hospitalHeart Surgery studyPreoperative cognitive assessmentUndergoing CABG surgeryBypass graft surgeryConfusion Assessment MethodRisk of deliriumDelirium risk factorsObservational cohort studyPostoperative day 2Clinical Dementia RatingDepression InterviewPreoperative depressionStructured HamiltonStudy psychiatrist
2017
Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease
Caspell-Garcia C, Simuni T, Tosun-Turgut D, Wu IW, Zhang Y, Nalls M, Singleton A, Shaw LA, Kang JH, Trojanowski JQ, Siderowf A, Coffey C, Lasch S, Aarsland D, Burn D, Chahine LM, Espay AJ, Foster ED, Hawkins KA, Litvan I, Richard I, Weintraub D, Initiative T. Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease. PLOS ONE 2017, 12: e0175674. PMID: 28520803, PMCID: PMC5435130, DOI: 10.1371/journal.pone.0175674.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersBrain-Derived Neurotrophic FactorCatechol O-MethyltransferaseCognitive DysfunctionDiffusion Tensor ImagingDopamine Plasma Membrane Transport ProteinsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedParkinson DiseasePolymorphism, Single NucleotideTau ProteinsTomography, Emission-Computed, Single-PhotonConceptsParkinson's diseaseCognitive impairmentDe novo Parkinson's diseaseDopamine transporter single-photon emissionLongitudinal mixed-effects modelsNovo Parkinson's diseaseYears of diseaseIdiopathic Parkinson's diseaseMovement Disorders CenterSingle nucleotide polymorphismsStructural magnetic resonance imagingClinical trial designLongitudinal structural MRIMagnetic resonance imagingSingle photon emissionDevelopment of treatmentsDiffusion tensor imagingBiomarker predictorsPlaque pathologyAmyloid pathologyDopamine deficiencyDopaminergic deficitUnivariate analysisBiomarker changesDisorders Center
2015
Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease
Weintraub D, Simuni T, Caspell‐Garcia C, Coffey C, Lasch S, Siderowf A, Aarsland D, Barone P, Burn D, Chahine M, Eberling J, Espay AJ, Foster ED, Leverenz JB, Litvan I, Richard I, Troyer MD, Hawkins KA, Initiative T. Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson's disease. Movement Disorders 2015, 30: 919-927. PMID: 25737166, PMCID: PMC4855523, DOI: 10.1002/mds.26170.Peer-Reviewed Original ResearchConceptsParkinson's Progression Markers InitiativeNeuropsychiatric symptomsPD patientsHealthy controlsProgression Markers InitiativeParkinson's diseaseCognitive impairmentUntreated PD patientsDopamine replacement therapySignificant depressive symptomsGroup differencesSymptoms of depressionQuality of lifeMild cognitive impairmentUntreated patientsDisease courseReplacement therapyICD symptomsControl disordersDepressive symptomsGeneral populationPatientsMeeting criteriaMulti-site studyBiological predictors
2012
The course of cognitive functioning over six months in individuals at clinical high risk for psychosis
Barbato M, Colijn MA, Keefe RS, Perkins DO, Woods SW, Hawkins KA, Christensen BK, Addington J. The course of cognitive functioning over six months in individuals at clinical high risk for psychosis. Psychiatry Research 2012, 206: 195-199. PMID: 23159196, PMCID: PMC3600156, DOI: 10.1016/j.psychres.2012.10.013.Peer-Reviewed Original ResearchConceptsClinical high riskCHR individualsComprehensive cognitive test batteryCognitive test batteryCognitive impairmentFuture longitudinal researchCognitive functioningCognitive performanceCognitive testsTest batteryLongitudinal researchCognitionPoor performanceLongitudinal changesPsychosisIndividualsParticipantsImpairmentBaseline participantsFunctioningPerformanceBatteriesResearchProdromeGlycine treatment of the risk syndrome for psychosis: Report of two pilot studies
Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: Report of two pilot studies. European Neuropsychopharmacology 2012, 23: 931-940. PMID: 23089076, PMCID: PMC4028140, DOI: 10.1016/j.euroneuro.2012.09.008.Peer-Reviewed Original ResearchConceptsPilot studyRisk syndromeSyndrome patientsNegative symptomsShort-term pilot studyEffect sizeAdjunctive antipsychotic medicationOpen-label studyPatients meeting criteriaNMDA receptor functionDurability of effectPsychosis risk symptomsGlycine site agonistsGroup effect sizesWeeks of evaluationAntipsychotic medicationSyndrome subjectsPromising effect sizesTreatment needsLarge effect sizesMeeting criteriaCognitive impairmentReduced symptomsReceptor functionSymptoms
2010
Verbal Fluency Deficits Co-Occur with Memory Deficits in Geriatric Patients at Risk for Dementia: Implications for the Concept of Mild Cognitive Impairment
Cottingham M, Hawkins K. Verbal Fluency Deficits Co-Occur with Memory Deficits in Geriatric Patients at Risk for Dementia: Implications for the Concept of Mild Cognitive Impairment. Behavioural Neurology 2010, 22: 73-79. DOI: 10.1155/2010/319128.Peer-Reviewed Original ResearchMemory deficitsMemory groupFluency performanceMild cognitive impairmentLower memory performanceCognitive impairmentPhonemic fluency taskMemory test scoresAmnestic mild cognitive impairmentAlzheimer's disease (AD) displayMemory patientsMemory performanceFluency taskMemory scoresSemantic fluencyCognitive complaintsFluency testMemory abilityFluency scoresDisease displayTest scoresDeficitsClinical presentationGeriatric patientsPatient group
2008
Everyday Decision-Making Ability in Older Persons With Cognitive Impairment
Lai JM, Gill TM, Cooney LM, Bradley EH, Hawkins KA, Karlawish JH. Everyday Decision-Making Ability in Older Persons With Cognitive Impairment. American Journal Of Geriatric Psychiatry 2008, 16: 693-696. PMID: 18669948, PMCID: PMC2730037, DOI: 10.1097/jgp.0b013e31816c7b54.Peer-Reviewed Original ResearchConceptsDecision-making abilityDecision-making capacityCognitive impairmentMacArthur Competency Assessment ToolExecutive functionMeasure of understandingOverall cognitionAssessment of capacityValid measureAlpha coefficientMedical treatment decisionsCronbach's alpha coefficientGood reliabilityImpairmentMeasuresACEDModerate correlationOlder personsCognitionAssessment toolPersonsAbilityReasoningCaregiversEveryday
2002
Factors Affecting Cognitive Functioning in a Sample of Human Immunodeficiency Virus-Positive Injection Drug Users
Margolin A, Avants SK, Warburton LA, Hawkins KA. Factors Affecting Cognitive Functioning in a Sample of Human Immunodeficiency Virus-Positive Injection Drug Users. AIDS Patient Care And STDs 2002, 16: 255-267. PMID: 12133261, DOI: 10.1089/10872910260066697.Peer-Reviewed Original ResearchConceptsCognitive functioningTest performanceNeuropsychological test performanceSelf-report measuresVisual-motor coordinationNP test performanceInjection drug usersEvidence of impairmentDrug useCognitive flexibilityNP test batteryVerbal informationNation's inner citiesTest batteryEducational attainmentDrug-abusing individualsDrug usersSubstance abuseCognitive impairmentIndependent contributionTreatment interventionsViral loadLittle researchPsychiatric problemsSuccessful engagementRelationship between Alcohol Consumption and Folstein Mini-Mental Status Examination Scores among Older Cognitively Impaired Adults
Reid MC, Maciejewski PK, Hawkins KA, Bogardus ST. Relationship between Alcohol Consumption and Folstein Mini-Mental Status Examination Scores among Older Cognitively Impaired Adults. Journal Of Geriatric Psychiatry And Neurology 2002, 15: 31-37. PMID: 11936241, DOI: 10.1177/089198870201500107.Peer-Reviewed Original ResearchConceptsAlcohol abuse/dependenceAbuse/dependenceCognitive screenMMSE subscoresLower total MMSE scoresMMSE scoresDistinctive cognitive profileCognitive impairmentBrief cognitive screenAdverse cognitive outcomesTotal MMSE scoreAlcohol historyCognitive measuresCognitive domainsCognitive profileAlcohol consumptionMini - mental status examination testMini-Mental Status Examination scoreCognitive outcomesAlcohol abuse/dependence disordersImpaired adultsCurrent alcohol intakeMiddle-aged adultsSignificant alcohol historyComprehensive geriatric assessment
2000
Verbal Fluency Deficits Co‐Occur with Memory Deficits in Geriatric Patients at Risk for Dementia: Implications for the Concept of Mild Cognitive Impairment
Cottingham ME, Hawkins KA. Verbal Fluency Deficits Co‐Occur with Memory Deficits in Geriatric Patients at Risk for Dementia: Implications for the Concept of Mild Cognitive Impairment. Behavioural Neurology 2000, 22: 73-79. PMID: 20595739, PMCID: PMC5434323, DOI: 10.3233/ben-2009-0246.Peer-Reviewed Original ResearchConceptsMemory deficitsMemory groupFluency performanceMild cognitive impairmentLower memory performanceCognitive impairmentPhonemic fluency taskMemory test scoresAmnestic mild cognitive impairmentAlzheimer's disease (AD) displayMemory patientsMemory performanceFluency taskMemory scoresSemantic fluencyCognitive complaintsFluency testMemory abilityFluency scoresDisease displayTest scoresDeficitsClinical presentationGeriatric patientsPatient group