William Bracamonte, MD, PhD
Clinical FellowAbout
Titles
Clinical Fellow
Biography
William Bracamonte Baran, MD PhD, is a physician scientist born in Venezuela. Earned his MD degree with honors from the Central University of Venezuela in 2004. After two years of practice in rural and underserved areas, he pursued an Internal Medicine residency at the Caracas University Hospital, with special emphasis in Rheumatology and autoimmunity. Then, he started a professor tenure in the Central University of Venezuela with appointment in the Department of Physiology, focusing on biophysics research, and clinical practice in the Department of Internal Medicine, focusing on diagnostic medicine and autoimmunity. In 2011 he moved to the USA to pursue a PhD in Immunology at the University of Wisconsin - Madison. His doctoral research led to discovery of mechanisms of allo-tolerance mediated by exosomes. He then obtained a post-doctoral position at Johns Hopkins University, where carried out translational research in the field of cardiac autoimmunity and transplant immunology. Once there, he made significant findings in the cardiac immunology field, mainly regarding properties of cardiac resident innate lymphoid cells, immunomodulatory role of cardiac endothelial cells via PDL1, amongst others. Aside of clinical and research experience, Dr. Bracamonte has developed extensive academic, teaching and mentoring activities and is reviewer of several peer-review indexed scientific journals. His work has been recognized by the American Heart Association, the American Autoimmune Related Disease Association, World Transplant Congress, amongst others, and produced multiple publications in recognized journals such PNAS and Circulation-Heart Failure. Aiming to continue a physician scientist career in the USA, he moved to Texas to complete a second Internal Medicine residency at Texas Tech University. Then he established a successful Internal Medicine practice at Midland Memorial Hospital, Texas. Dr. Bracamonte entered the Rheumatology Fellowship Program at Yale University in July 2023.
Departments & Organizations
Education & Training
- Resident
- Texas Tech University (2021)
- Postdoctoral Research
- John Hopkins University (2019)
- PhD
- University of Wisconsin - Madison (2015)
- Resident
- Universidad Central de Venezuela - Hospital Universitario de Caracas (2009)
- MD
- Luis Razetti Medical School, Central University of Venezuela (2004)
Research
Research at a Glance
Yale Co-Authors
Publications Timeline
Sang Taek Kim, MD, PhD
Publications
2024
The protective role of GATA6+ pericardial macrophages in pericardial inflammation
Hughes D, Won T, Talor M, Kalinoski H, Jurčová I, Szárszoi O, Stříž I, Čurnová L, Bracamonte-Baran W, Melenovský V, Čiháková D. The protective role of GATA6+ pericardial macrophages in pericardial inflammation. IScience 2024, 27: 110244. PMID: 39040070, PMCID: PMC11260870, DOI: 10.1016/j.isci.2024.110244.Peer-Reviewed Original ResearchConceptsMyocardial infarctionMyocardial inflammationPericardial inflammationTrafficking of inflammatory monocytesCoxsackievirus B3-induced myocarditisUpregulation of inflammatory markersPreventing interstitial fibrosisCardiac function post-MIStimulated in vitroFunction post-MIInduced pericarditisInflammatory monocytesInflammatory markersBone marrowInterstitial fibrosisCardiac fibrosisAttenuated traffickingPost-MIInflammationInduced upregulationFibrosisMacrophagesGATA6Pericardial cavityCoxsackievirus B3The Current and Future of Biomarkers of Immune Related Adverse Events
Bracamonte-Baran W, Kim S. The Current and Future of Biomarkers of Immune Related Adverse Events. Rheumatic Disease Clinics Of North America 2024, 50: 201-227. PMID: 38670721, PMCID: PMC11232920, DOI: 10.1016/j.rdc.2024.01.004.Peer-Reviewed Original Research
2021
Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8+ T-Cell Infiltration After Heart Transplantation
Bracamonte-Baran W, Gilotra N, Won T, Rodriguez K, Talor M, Oh B, Griffin J, Wittstein I, Sharma K, Skinner J, Johns R, Russell S, Anders R, Zhu Q, Halushka M, Brandacher G, Čiháková D. Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8+ T-Cell Infiltration After Heart Transplantation. Circulation Heart Failure 2021, 14: e007982. PMID: 34555935, PMCID: PMC8550427, DOI: 10.1161/circheartfailure.120.007982.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPD-L1 expressionT cell infiltrationPD-L1Heart transplantationEndothelial cellsHemodynamic parametersPD1/PD-L1 axisCD8 T-cell ratioMultivariate logistic regression analysisPeripheral blood mononuclear cellsMurine model resultsGraft endothelial cellsHeart transplant patientsPD-L1 axisT cell frequenciesT cell ratioHeart transplantation modelSurveillance endomyocardial biopsiesBlood mononuclear cellsHuman heart transplantationLogistic regression analysisGraft expressionLeukocyte compartmentLeukocyte patternModulates CD8
2020
Complete recovery of fulminant cytotoxic CD8 T‐cell‐mediated myocarditis after ECMELLA unloading and immunosuppression
Jurcova I, Rocek J, Bracamonte‐Baran W, Zelizko M, Netuka I, Maluskova J, Kautzner J, Cihakova D, Melenovsky V, Maly J. Complete recovery of fulminant cytotoxic CD8 T‐cell‐mediated myocarditis after ECMELLA unloading and immunosuppression. ESC Heart Failure 2020, 7: 1976-1981. PMID: 32485066, PMCID: PMC7373888, DOI: 10.1002/ehf2.12697.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMechanical circulatory supportCirculatory supportT cell-mediated myocarditisTemporary mechanical circulatory supportThird-degree atrioventricular blockWeeks of supportSevere biventricular failureT-cell predominanceExtracorporeal membrane oxygenationPrevious cardiac historyBiventricular failureCardiogenic shockVentricular dysfunctionLymphocytic myocarditisCardiac historyEndomyocardial biopsyMembrane oxygenationAtrioventricular blockVentricular unloadingMacrophage expansionMyocarditisFlow cytometryComplete recoverySustained recoveryImmunosuppressionCharacteristics and Outcomes of Pulmonary Angioplasty With or Without Stenting for Sarcoidosis-Associated Pulmonary Hypertension: Systematic Review and Individual Participant Data Meta-Analysis
daSilva-deAbreu A, Bracamonte-Baran W, Condado J, Babaliaros V, Tafur-Soto J, Mandras S. Characteristics and Outcomes of Pulmonary Angioplasty With or Without Stenting for Sarcoidosis-Associated Pulmonary Hypertension: Systematic Review and Individual Participant Data Meta-Analysis. Current Problems In Cardiology 2020, 46: 100616. PMID: 32532452, DOI: 10.1016/j.cpcardiol.2020.100616.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSarcoidosis-associated pulmonary hypertensionIndividual participant dataPulmonary angioplastyPulmonary hypertensionCase reportIndividual Participant Data Meta-AnalysisMulticenter registry studyNYHA FC IIIPulmonary vascular stenosisControlled Clinical TrialsSmall case seriesData Meta-AnalysisRegistry studyCase seriesFC IIIFocal stenosisDefinitive diagnosisClinical trialsPulmonary vesselsOutcome dataVascular stenosisStage IIIPatientsAngioplastySignificant improvementInnate Lymphoid Cells Play a Pathogenic Role in Pericarditis
Choi H, Won T, Hou X, Chen G, Bracamonte-Baran W, Talor M, Jurčová I, Szárszoi O, Čurnova L, Stříž I, Hooper J, Melenovský V, Čiháková D. Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis. Cell Reports 2020, 30: 2989-3003.e6. PMID: 32130902, PMCID: PMC7332109, DOI: 10.1016/j.celrep.2020.02.040.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsCell MovementChemokine CCL11Disease SusceptibilityEosinophilsFemaleFibroblastsGene Expression RegulationHeartHeart Function TestsHumansImmunity, InnateInterleukin-1 Receptor-Like 1 ProteinInterleukin-33Interleukin-5LymphocytesMaleMediastinumMice, Inbred BALB CPericarditisSignal TransductionUp-RegulationConceptsInnate lymphoid cellsEosinophilic pericarditisPathogenic roleMediastinal cavityLymphoid cellsGroup 2 innate lymphoid cellsCardiac fibroblastsDevelopment of pericarditisCardiac inflammationEotaxin-1Healthy controlsPericardial fluidCardiac diseasePericarditisB cellsSerous cavitiesILC2sEosinophilsPatientsMiceHeartCellsCritical roleFibroblastsInflammationTreg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance
Sullivan J, Tomita Y, Jankowska-Gan E, Lema D, Arvedson M, Nair A, Bracamonte-Baran W, Zhou Y, Meyer K, Zhong W, Sawant D, Szymczak-Workman A, Zhang Q, Workman C, Hong S, Vignali D, Burlingham W. Treg-Cell-Derived IL-35-Coated Extracellular Vesicles Promote Infectious Tolerance. Cell Reports 2020, 30: 1039-1051.e5. PMID: 31995748, PMCID: PMC7042971, DOI: 10.1016/j.celrep.2019.12.081.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsB-LymphocytesCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCoculture TechniquesExtracellular VesiclesFemaleForkhead Transcription FactorsGene Knockout TechniquesHeart TransplantationImmune ToleranceImmunosuppression TherapyInterleukin-12 Subunit p35InterleukinsMiceMice, Inbred C57BLMice, Inbred CBAMice, TransgenicMicroscopy, Electron, TransmissionMinor Histocompatibility AntigensReceptors, CytokineT-Lymphocytes, RegulatoryConceptsIL-35Treg cellsInfectious toleranceExtracellular vesiclesExpression of Ebi3T regulatory (Treg) cellsImmunosuppressive cytokinesInterleukin-35Peripheral toleranceRegulatory cellsEpstein-BarrBystander lymphocytesSecondary suppressionReporter miceB lymphocytesEBI3Protein 3Foxp3LymphocytesGene reporterNovel mechanismP35 proteinCellsEV productionTregs
2019
Decreasing Rates of Acute Kidney Injury After Percutaneous Coronary Interventions Through Education and Standardized Order Sets in a Large Tertiary Teaching Center
daSilva-deAbreu A, Gurung S, Bracamonte-Baran W, Byrnes P, Balan P, Finkel K, Smalling R, Anderson H, Arain S. Decreasing Rates of Acute Kidney Injury After Percutaneous Coronary Interventions Through Education and Standardized Order Sets in a Large Tertiary Teaching Center. Current Problems In Cardiology 2019, 46: 100453. PMID: 31526518, DOI: 10.1016/j.cpcardiol.2019.100453.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsAcute kidney injuryPercutaneous coronary interventionAKI ratesKidney injuryCoronary interventionCardiac angiographyPost-PCI acute kidney injuryNational Cardiovascular Data RegistryTertiary teaching centerCare of patientsStandardized order setsStandardized electronic medical recordElectronic medical recordsCommon complicationTertiary centerMedical recordsCare teamData registryHealthcare costsMultilevel interventionsOrder setsTeaching centerPatientsAngiographyInterventionThe Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis
Hou X, Chen G, Bracamonte-Baran W, Choi H, Diny N, Sung J, Hughes D, Won T, Wood M, Talor M, Hackam D, Klingel K, Davogustto G, Taegtmeyer H, Coppens I, Barin J, Čiháková D. The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis. Cell Reports 2019, 28: 172-189.e7. PMID: 31269438, PMCID: PMC6813836, DOI: 10.1016/j.celrep.2019.06.007.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsAntigens, LyCell DifferentiationCell ProliferationC-Mer Tyrosine KinaseDisease Models, AnimalFibroblastsHumansInflammationInterleukin-17MacrophagesMiceMice, Inbred BALB CMice, KnockoutMicroscopy, Electron, TransmissionMonocytesMyocarditisMyocardiumParabiosisSignal TransductionTranscriptomeConceptsExperimental autoimmune myocarditisMonocyte-derived macrophagesIL-17AHeart failureCardiac fibroblastsMurine experimental autoimmune myocarditisIL-17A levelsMacrophage differentiationAutoimmune myocarditisAcute phaseCardiac fibrosisClinical correlationReceptor expressionLy6CMonocyte fateTypes of monocytesMacrophagesMyocarditisMHCIIMonocytesFibroblastsSupDifferentiationFibrosisSequalaeNon-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population
Bracamonte-Baran W, Chen G, Hou X, Talor M, Choi H, Davogustto G, Taegtmeyer H, Sung J, Hackam D, Nauen D, Čiháková D. Non-cytotoxic Cardiac Innate Lymphoid Cells Are a Resident and Quiescent Type 2-Commited Population. Frontiers In Immunology 2019, 10: 634. PMID: 30984196, PMCID: PMC6450181, DOI: 10.3389/fimmu.2019.00634.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInnate lymphoid cellsIL-33 productionProgenitor-like featuresLymphoid cellsType 2IL-25 receptorNatural killer cellsSubsets of leukocytesAntigen-specific receptorsILC2 expansionInflammatory ILC2sAdoptive transferCardiac inflammationIL-33Killer cellsInflammatory conditionsMouse modelHealthy humansIschemic conditionsCardiac fibroblastsGATA3 expressionILC2Pathologic environmentHealthy heartIschemia
Academic Achievements & Community Involvement
honor Translational Research Award
National AwardAmerican Autoimmune Related Disease AssociationDetails02/01/2016United Stateshonor Postdoctoral Fellowship Award
National AwardAmerican Heart AssociationDetails11/01/2015United Stateshonor Young Investigator Award
International AwardWorld Transplant Congress - 2014Details06/13/2014United States