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INFORMATION FOR

Christian Felipe Ruiz, PhD

Associate Research Scientist in Genetics
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About

Titles

Associate Research Scientist in Genetics

Appointments

  • Genetics

    Associate Research Scientist
    Primary
    Genetics

Other Departments & Organizations

Education & Training

PhD
Stony Brook University, Genetics (2019)
BE
The City College of New York, Biomedical Engineering (2013)

Research

Overview

I am an Associate Research Scientist in the Department of Genetics and the Cancer Biology Institute at Yale University. I trained in quantitative mass spectrometry–based studies of metabolism as a Ph.D. student and, as a postdoc, applied genetically engineered mouse models and dietary interventions to uncover metabolic programs that shape host physiology and disease. With this combination of skills, my long-term goal is to establish a mechanistic bridge between environmental metabolites – derived from diet or the gut microbiome – and tissue metabolism, adaptation, and disease initiation, revealing how nutrient composition shapes disease risk and outcome. My training enables me to integrate systems-level and mechanistic analyses with in vivo studies, linking molecular and physiological scales. I am equally committed to fostering an inclusive, rigorous environment that supports the growth of trainees from diverse and underrepresented backgrounds

Research at a Glance

Yale Co-Authors

Frequent collaborators of Christian Felipe Ruiz's published research.

Publications

2026

  • Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas.
    Ruiz CF, Ge X, McDonnell R, Agabiti SS, McQuaid DC, Tang A, Kharwa M, Goodell J, Saavedra-Pena RDM, Wing A, Li G, Medici NP, Robert ME, Varshney RR, Rudolph MC, Gorelick FS, Wysolmerski J, Canals D, Haley JD, Rodeheffer MS, Muzumdar MD. Diet-induced phospholipid remodeling dictates ferroptosis sensitivity and tumorigenesis in the pancreas. Cancer Discov 2026 PMID: 42053430, DOI: 10.1158/2159-8290.CD-25-0734.
    Peer-Reviewed Original Research
    This study investigates how dietary fat composition influences pancreatic cancer, showing that monounsaturated fats promote tumor growth while polyunsaturated fats reduce risk by enhancing ferroptosis sensitivity.
    Full Summary
  • Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development
    Garcia CC, Venkat A, McQuaid DC, Agabiti SS, Tong A, Mathew B, Cardone RL, Starble R, Ruiz CF, Zheng C, Sogunro A, Jacox JB, Loh KH, Kibbey RG, Krishnaswamy S, Muzumdar MD. Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development. Nature Communications 2026 DOI: 10.1038/s41467-026-69821-2.
    Peer-Reviewed Original Research
    This study investigates how beta cell-derived cholecystokinin drives obesity-associated pancreatic cancer development, showing that targeting endocrine signaling could prevent tumor progression in obesity-related contexts.
    Full Summary

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Contacts

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