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Second Primary Malignancies of the Bones and Joints: More Common than Expected in Osteosarcoma Patients
Osteosarcoma is the most common primary bone tumor in children, adolescents, and young adults worldwide, with an incidence of 3.4 million people per year. It is usually found in appendicular skeleton, such as the distal femur (43%), proximal tibia (23%), or humerus (10%), but may also arise axially. Although most common in younger patients, there is an increasing prevalence among elderly patients.