Nicola Santoro, MD, PhD

• Alfonso Galderisi
• Michelle Van Name
• Stephanie Samuels

Metabolic Diseases; Nutrition Disorders

Genetics, Genomics, Epigenetics; Metabolism; Nutrition; Obesity; Child/Adolescent Health

• Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesityGalderisi A, Tricò D, Lat J, Samuels S, Weiss R, Van Name M, Pierpont B, Santoro N, Caprio S. Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity. JCI Insight 2023, 8: e165709. PMID: 37847560, PMCID: PMC10721315, DOI: 10.1172/jci.insight.165709.
• High-frequency variants in PKA signaling-related genes within a large pediatric cohort with obesity or metabolic abnormalitiesBloyd M, Sinaii N, Faucz F, Iben J, Coon S, Caprio S, Santoro N, Stratakis C, London E. High-frequency variants in PKA signaling-related genes within a large pediatric cohort with obesity or metabolic abnormalities. Frontiers In Endocrinology 2023, 14: 1272939. PMID: 38027204, PMCID: PMC10679389, DOI: 10.3389/fendo.2023.1272939.
• The lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesityUmano G, Cirillo G, Sanchez G, Rondinelli G, Foderini M, Ferrara S, Di Sessa A, Marzuillo P, Papparella A, Santoro N, del Giudice E. The lncOb rs10487505 polymorphism impairs insulin sensitivity and glucose tolerance in children and adolescents with obesity. Obesity 2023, 31: 2359-2364. PMID: 37550829, DOI: 10.1002/oby.23835.
• Proatherogenic changes in lipoprotein particles associated with a high triglyceride to high‐density lipoprotein cholesterol ratio in youthsChiriacò M, Nesti L, Natali A, Santoro N, Caprio S, Tricò D. Proatherogenic changes in lipoprotein particles associated with a high triglyceride to high‐density lipoprotein cholesterol ratio in youths. Obesity 2023, 31: 1894-1902. PMID: 37227148, PMCID: PMC10330115, DOI: 10.1002/oby.23767.
• Comparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With ObesityGaluppo B, Umano G, Li Z, Van Name M, Samuels S, Kien C, Cline G, Wagner D, Barbieri E, Tricò D, Santoro N. Comparison of Metabolic Response to Colonic Fermentation in Lean Youth vs Youth With Obesity. JAMA Network Open 2023, 6: e2312530. PMID: 37159195, PMCID: PMC10170343, DOI: 10.1001/jamanetworkopen.2023.12530.
• Study protocol for a randomized, controlled trial using a novel, family-centered diet treatment to prevent NAFLD in Hispanic childrenWelsh J, Pyo E, Huneault H, Ramirez L, Alazraki A, Alli R, Dunbar S, Khanna G, Knight-Scott J, Pimentel A, Reed B, Rodney-Somersall C, Santoro N, Umpierrez G, Vos M. Study protocol for a randomized, controlled trial using a novel, family-centered diet treatment to prevent NAFLD in Hispanic children. Contemporary Clinical Trials 2023, 129: 107170. PMID: 37019180, PMCID: PMC10734403, DOI: 10.1016/j.cct.2023.107170.
• Clinical features and metabolic complications for non-alcoholic fatty liver disease (NAFLD) in youth with obesityBarbieri E, Santoro N, Umano G. Clinical features and metabolic complications for non-alcoholic fatty liver disease (NAFLD) in youth with obesity. Frontiers In Endocrinology 2023, 14: 1062341. PMID: 36733529, PMCID: PMC9887046, DOI: 10.3389/fendo.2023.1062341.
• Nonalcoholic Fatty Liver Disease (NAFLD) Association with Pediatric DiabetesSantoro N, Goldberg-Gel R, Caprio S. Nonalcoholic Fatty Liver Disease (NAFLD) Association with Pediatric Diabetes. 2021, 181-189. DOI: 10.1007/978-3-030-64133-7_17.
• rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysisTeo K, Abeysekera KWM, Adams L, Aigner E, Anstee QM, Banales JM, Banerjee R, Basu P, Berg T, Bhatnagar P, Buch S, Canbay A, Caprio S, Chatterjee A, Chen Y, Chowdhury A, Daly AK, Datz C, de Gracia Hahn D, DiStefano JK, Dong J, Duret A, Investigators E, Vreugdenhil A, Alisi A, Socha P, Jańczyk W, Baumann U, Rajwal S, van Mourik I, Lacaille F, Dabbas M, Kelly D, Nobili V, Emdin C, Fairey M, Gerhard G, Consortium G, Eiriksdottir G, Garcia M, Gudnason V, Harris T, Kim L, Launer L, Nalls M, Smith A, Clark J, Hernaez R, Kao W, Mitchell B, Shuldiner A, Yerges-Armstrong L, Borecki I, Carr J, Feitosa M, Wu J, Butler J, Fox C, Hirschhorn J, Hoffmann U, Hwang S, Massaro J, O'Donnell C, Palmer C, Sahani D, Speliotes E, Guo X, Hampe J, Hickman M, Heintz L, Hudert C, Hunter H, Kelly M, Kozlitina J, Krawczyk M, Lammert F, Langenberg C, Lavine J, Li L, Lim H, Loomba R, Luukkonen P, Melton P, Mori T, Palmer N, Parisinos C, Pillai S, Qayyum F, Reichert M, Romeo S, Rotter J, Im Y, Santoro N, Schafmayer C, Speliotes E, Stender S, Stickel F, Still C, Strnad P, Taylor K, Tybjærg-Hansen A, Umano G, Utukuri M, Valenti L, Wagenknecht L, Wareham N, Watanabe R, Wattacheril J, Yaghootkar H, Yki-Järvinen H, Young K, Mann J. rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis. Journal Of Hepatology 2020, 74: 20-30. PMID: 32882372, PMCID: PMC7755037, DOI: 10.1016/j.jhep.2020.08.027.
• Fatty liver, irrespective of ethnicity, is associated with reduced insulin clearance and insulin resistance in obese youthsTrico D, Galderisi A, Galuppo B, Pierpont B, Samuels S, Santoro N, Caprio S. Fatty liver, irrespective of ethnicity, is associated with reduced insulin clearance and insulin resistance in obese youths. Endocrine Abstracts 2020 DOI: 10.1530/endoabs.70.aep256.
• Effect of gut microbiota and PNPLA3 rs738409 variant on non-alcoholic fatty liver disease (NAFLD) in obese youthKravetz A, Testerman T, Galuppo B, Graf J, Pierpont B, Siebel S, Feinn R, Santoro N. Effect of gut microbiota and PNPLA3 rs738409 variant on non-alcoholic fatty liver disease (NAFLD) in obese youth. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: dgaa382-. PMID: 32561908, PMCID: PMC7458486, DOI: 10.1210/clinem/dgaa382.
• 61-OR: Genetic and Metabolic Determinants of the Incretin Effect in Obese Adolescent with PrediabetesGALDERISI A, SAMUELS S, PIERPONT B, MAN C, SANTORO N, CAPRIO S. 61-OR: Genetic and Metabolic Determinants of the Incretin Effect in Obese Adolescent with Prediabetes. Diabetes 2020, 69 DOI: 10.2337/db20-61-or.
• 1273-P: Growth Differentiation Factor 15 (GDF15) Is Associated with Nonalcoholic Fatty Liver Disease (NAFLD) in Obese YouthGALUPPO B, AGAZZI C, PIERPONT B, SAMUELS S, TARABRA E, CAPRIO S, SANTORO N. 1273-P: Growth Differentiation Factor 15 (GDF15) Is Associated with Nonalcoholic Fatty Liver Disease (NAFLD) in Obese Youth. Diabetes 2020, 69 DOI: 10.2337/db20-1273-p.
• 1819-P: Gut Microbiota and PNPLA3 RS738409 Associated with Nonalcoholic Fatty Liver Disease in Obese YouthKRAVETZ A, TESTERMAN T, GALUPPO B, GRAF J, SIEBEL S, FEINN R, SANTORO N. 1819-P: Gut Microbiota and PNPLA3 RS738409 Associated with Nonalcoholic Fatty Liver Disease in Obese Youth. Diabetes 2020, 69 DOI: 10.2337/db20-1819-p.
• OR22-07 Novel Variants in Protein Kinase a Signaling-Related Genes Identified in Obese Children with and Without NAFLDBloyd M, Coon S, Iben J, Sinaii N, Faucz F, Santoro N, Caprio S, Stratakis C, London E. OR22-07 Novel Variants in Protein Kinase a Signaling-Related Genes Identified in Obese Children with and Without NAFLD. Journal Of The Endocrine Society 2020, 4: or22-07. PMCID: PMC7207807, DOI: 10.1210/jendso/bvaa046.1880.
• 772-P: Effect of a Low n6/n3 PUFA Diet on Intrahepatic Fat Content in Obese AdolescentsVAN NAME M, CHICK J, SAVOYE M, PIERPONT B, GALUPPO B, FELDSTEIN A, SANTORO N. 772-P: Effect of a Low n6/n3 PUFA Diet on Intrahepatic Fat Content in Obese Adolescents. Diabetes 2019, 68 DOI: 10.2337/db19-772-p.
• 121-OR: Insulin Clearance Is an Independent Determinant of ß-Cell Cell Function in Obese YouthsGALDERISI A, TRICO D, GIANNINI C, SANTORO N, CAPRIO S, WEISS R. 121-OR: Insulin Clearance Is an Independent Determinant of ß-Cell Cell Function in Obese Youths. Diabetes 2019, 68 DOI: 10.2337/db19-121-or.
• 128-OR: Clustering of Metabolomics, Clinical Biomarkers, and Ectopic Liver Fat in Children/Adolescents: An Integrated Network AnalysisCIOFFI C, VENKAT NARAYAN K, UPPAL K, PIERPONT B, CAPRIO S, SANTORO N, VOS M. 128-OR: Clustering of Metabolomics, Clinical Biomarkers, and Ectopic Liver Fat in Children/Adolescents: An Integrated Network Analysis. Diabetes 2019, 68 DOI: 10.2337/db19-128-or.
• 1317-P: Static, but Nondynamic, ß-Cell Responsiveness to Glucose Is Affected by the Risk Variant rs7903146 of TCF7L2 and Associated with a Delayed Time-to-Glucose-Peak in Obese YouthsGALDERISI A, TRICO D, MAN C, SIEBEL S, SANTORO N, PIERPONT B, COBELLI C, CAPRIO S. 1317-P: Static, but Nondynamic, ß-Cell Responsiveness to Glucose Is Affected by the Risk Variant rs7903146 of TCF7L2 and Associated with a Delayed Time-to-Glucose-Peak in Obese Youths. Diabetes 2019, 68 DOI: 10.2337/db19-1317-p.
• 177-OR: Genome-Wide Association Study of Lipid Traits in Youth with Type 2 Diabetes: The ProDiGY (Progress in Diabetes Genetics in Youth) ConsortiumCHEN L, SRINIVASAN S, SANTORO N, TODD J, DIVERS J, SHAH A, GIDDING S, BURKE B, HAYMOND M, LANGE L, MARCOVINA S, CHAIT A, FLANNICK J, CAPRIO S, FLOREZ J. 177-OR: Genome-Wide Association Study of Lipid Traits in Youth with Type 2 Diabetes: The ProDiGY (Progress in Diabetes Genetics in Youth) Consortium. Diabetes 2019, 68 DOI: 10.2337/db19-177-or.
• Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controlsFlannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, Chen S, Contreras-Cubas C, Córdova E, Correa A, Cortes M, DeFronzo RA, Dolan L, Drews KL, Elliott A, Floyd JS, Gabriel S, Garay-Sevilla ME, García-Ortiz H, Gross M, Han S, Heard-Costa NL, Jackson AU, Jørgensen ME, Kang HM, Kelsey M, Kim BJ, Koistinen HA, Kuusisto J, Leader JB, Linneberg A, Liu CT, Liu J, Lyssenko V, Manning AK, Marcketta A, Malacara-Hernandez JM, Martínez-Hernández A, Matsuo K, Mayer-Davis E, Mendoza-Caamal E, Mohlke KL, Morrison AC, Ndungu A, Ng MCY, O’Dushlaine C, Payne AJ, Pihoker C, Post W, Preuss M, Psaty B, Vasan R, Rayner N, Reiner A, Revilla-Monsalve C, Robertson N, Santoro N, Schurmann C, So W, Soberón X, Stringham H, Strom T, Tam C, Thameem F, Tomlinson B, Torres J, Tracy R, van Dam R, Vujkovic M, Wang S, Welch R, Witte D, Wong T, Atzmon G, Barzilai N, Blangero J, Bonnycastle L, Bowden D, Chambers J, Chan E, Cheng C, Cho Y, Collins F, de Vries P, Duggirala R, Glaser B, Gonzalez C, Gonzalez M, Groop L, Kooner J, Kwak S, Laakso M, Lehman D, Nilsson P, Spector T, Tai E, Tuomi T, Tuomilehto J, Wilson J, Aguilar-Salinas C, Bottinger E, Burke B, Carey D, Chan J, Dupuis J, Frossard P, Heckbert S, Hwang M, Kim Y, Kirchner H, Lee J, Lee J, Loos R, Ma R, Morris A, O’Donnell C, Palmer C, Pankow J, Park K, Rasheed A, Saleheen D, Sim X, Small K, Teo Y, Haiman C, Hanis C, Henderson B, Orozco L, Tusié-Luna T, Dewey F, Baras A, Gieger C, Meitinger T, Strauch K, Lange L, Grarup N, Hansen T, Pedersen O, Zeitler P, Dabelea D, Abecasis G, Bell G, Cox N, Seielstad M, Sladek R, Meigs J, Rich S, Rotter J, Altshuler D, Burtt N, Scott L, Morris A, Florez J, McCarthy M, Boehnke M. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature 2019, 570: 71-76. PMID: 31118516, PMCID: PMC6699738, DOI: 10.1038/s41586-019-1231-2.
• Chapter 11 Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes Pathophysiologic Links and Potential ImplicationsGalderisi A, Martino M, Santoro N. Chapter 11 Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes Pathophysiologic Links and Potential Implications. 2019, 91-99. DOI: 10.1016/b978-0-323-55138-0.00011-5.
• Metabolic Features of Nonalcoholic Fatty Liver (NAFL) in Obese Adolescents: Findings From a Multiethnic CohortTricò D, Caprio S, Umano G, Pierpont B, Nouws J, Galderisi A, Kim G, Mata MM, Santoro N. Metabolic Features of Nonalcoholic Fatty Liver (NAFL) in Obese Adolescents: Findings From a Multiethnic Cohort. Hepatology 2018, 68: 1376-1390. PMID: 29665034, PMCID: PMC6173637, DOI: 10.1002/hep.30035.
• The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing beta-Cell Function and Hepatic Insulin SensitivityC C, N S, L G, C D, C C, A G, R K, B P, M G, S C. The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing beta-Cell Function and Hepatic Insulin Sensitivity. 2018 DOI: 10.1530/ey.15.12.3.
• Ethnicity and Common Genetic Variants Modulate Nonalcoholic Fatty Liver Disease (NAFLD) Metabolic Phenotype in Obese YouthTRICO D, CAPRIO S, UMANO G, GALDERISI A, MATA M, NOUWS J, PIERPONT B, KIM G, SANTORO N. Ethnicity and Common Genetic Variants Modulate Nonalcoholic Fatty Liver Disease (NAFLD) Metabolic Phenotype in Obese Youth. Diabetes 2018, 67 DOI: 10.2337/db18-313-or.
• The TCF7L2 Variant rs7903146 Affects the Risk of Youth-Onset Type 2 Diabetes by Reducing the Incretin Effect on Insulin SecretionGALDERISI A, PIERPONT B, D'ALESSIO D, SANTORO N, CAPRIO S. The TCF7L2 Variant rs7903146 Affects the Risk of Youth-Onset Type 2 Diabetes by Reducing the Incretin Effect on Insulin Secretion. Diabetes 2018, 67 DOI: 10.2337/db18-340-or.
• The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese YouthUmano GR, Caprio S, Di Sessa A, Chalasani N, Dykas DJ, Pierpont B, Bale AE, Santoro N. The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth. The American Journal Of Gastroenterology 2018, 113: 376. PMID: 29485130, DOI: 10.1038/ajg.2018.1.
• Chapter 4 Obesity and Type 2 Diabetes in Youths New Challenges to OvercomeSantoro N, Giannini C, Caprio S. Chapter 4 Obesity and Type 2 Diabetes in Youths New Challenges to Overcome. 2018, 43-52. DOI: 10.1016/b978-0-12-812019-4.00004-0.
• Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota?Tricò D, Di Sessa A, Caprio S, Chalasani N, Liu W, Liang T, Graf J, Herzog R, Johnson CD, Umano GR, Feldstein AE, Santoro N. Oxidized Derivatives of Linoleic Acid in Pediatric Metabolic Syndrome: Is Their Pathogenic Role Modulated by the Genetic Background and the Gut Microbiota? Antioxidants & Redox Signaling 2017, 30: 241-250. PMID: 28279074, PMCID: PMC6277079, DOI: 10.1089/ars.2017.7049.
• Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic studyGoffredo M, Caprio S, Feldstein AE, D'Adamo E, Shaw MM, Pierpont B, Savoye M, Zhao H, Bale AE, Santoro N. Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study. Hepatology 2016, 63: 117-125. PMID: 26457389, PMCID: PMC4688225, DOI: 10.1002/hep.28283.
• A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese AdolescentsKursawe R, Dixit VD, Scherer PE, Santoro N, Narayan D, Gordillo R, Giannini C, Lopez X, Pierpont B, Nouws J, Shulman GI, Caprio S. A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents. Diabetes 2015, 65: 610-618. PMID: 26718495, PMCID: PMC4764142, DOI: 10.2337/db15-1478.
• Metabolic Syndrome in Childhood as a Risk Factor for Type 2 DiabetesSantoro N, Giannini C, Caprio S. Metabolic Syndrome in Childhood as a Risk Factor for Type 2 Diabetes. 2012, 83-91. DOI: 10.1007/978-1-4471-2366-8_4.
• Chapter 6 Obesity and Type 2 Diabetes in Youths New Challenges to OvercomeSantoro N, Giannini C, Caprio S. Chapter 6 Obesity and Type 2 Diabetes in Youths New Challenges to Overcome. 2012, 77-87. DOI: 10.1016/b978-0-12-385083-6.00006-1.
• Growth acceleration in prepubertal obese children: role of hyperinsulinaemia.Santoro N, Miraglia Del Giudice E, Coppola F, Luongo C, Perrone L. Growth acceleration in prepubertal obese children: role of hyperinsulinaemia. Acta Paediatrica 2006, 95: 887-8. PMID: 16801195, DOI: 10.1080/08035250600580560.
• Mutational Screening of the CART Gene in Obese Children Identifying a Mutation (Leu34Phe) Associated With Reduced Resting Energy Expenditure and Cosegregating With Obesity Phenotype in a Large Familydel Giudice E, Santoro N, Cirillo G, D’Urso L, Di Toro R, Perrone L. Mutational Screening of the CART Gene in Obese Children Identifying a Mutation (Leu34Phe) Associated With Reduced Resting Energy Expenditure and Cosegregating With Obesity Phenotype in a Large Family. Diabetes 2001, 50: 2157-2160. PMID: 11522684, DOI: 10.2337/diabetes.50.9.2157.