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Alfonso Galderisi, MD, PhD

he/him/his

Assistant Professor

Research & Publications
Biography
News

Coauthors

Selected Publications

Williams Textbook of EndocrinologyChapter 36 : Digitalized Approaches to Diabetes Diagnostics and Therapeutics. Battelino T, Sherr J, Galderisi A, Dovc K. in press
Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesityGalderisi A, Tricò D, Lat J, Samuels S, Weiss R, Van Name M, Pierpont B, Santoro N, Caprio S. Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity. JCI Insight 2023, 8: e165709. PMID: 37847560, PMCID: PMC10721315, DOI: 10.1172/jci.insight.165709.
Glucose pattern in children with classical congenital adrenal hyperplasia: evidence from continuous glucose monitoringGalderisi A, Kariyawasam D, Stoupa A, Quoc A, Pinto G, Viaud M, Brabant S, Beltrand J, Polak M, Samara-Boustani D. Glucose pattern in children with classical congenital adrenal hyperplasia: evidence from continuous glucose monitoring. European Journal Of Endocrinology 2023, 189: k19-k24. PMID: 37952170, DOI: 10.1093/ejendo/lvad147.
Alterations in adipose tissue distribution, cell morphology and function mark primary insulin hypersecretion in youths with obesity.Tricò D, Chiriacò M, Nouws J, Vash-Margita A, Kursawe R, Tarabra E, Galderisi A, Natali A, Giannini C, Hellerstein M, Ferrannini E, Caprio S. Alterations in adipose tissue distribution, cell morphology and function mark primary insulin hypersecretion in youths with obesity. Diabetes 2023 PMID: 37870826, DOI: 10.2337/db23-0450.
Nurturing the next generation of pediatric physician scientists: the Padova Physician Scientist Research Training for pediatric residentsGalderisi A, Bressan S, Da Dalt L, Perilongo G, Baraldi E. Nurturing the next generation of pediatric physician scientists: the Padova Physician Scientist Research Training for pediatric residents. European Journal Of Pediatrics 2023, 1-4. PMID: 37851083, DOI: 10.1007/s00431-023-05258-9.
Quantifying beta cell function in the preclinical stages of type 1 diabetesGalderisi A, Carr A, Martino M, Taylor P, Senior P, Dayan C. Quantifying beta cell function in the preclinical stages of type 1 diabetes. Diabetologia 2023, 66: 2189-2199. PMID: 37712956, PMCID: PMC10627950, DOI: 10.1007/s00125-023-06011-5.
Sumatriptan, a serotonin 5HT1B receptor agonist, acutely reduces insulin secretion and sensitivity and glucose effectiveness in overweight humans: A double‐blinded placebo‐controlled cross‐over trialGolubic R, Ismail M, Josipovic M, Kennet J, Galderisi A, Evans M. Sumatriptan, a serotonin 5HT1B receptor agonist, acutely reduces insulin secretion and sensitivity and glucose effectiveness in overweight humans: A double‐blinded placebo‐controlled cross‐over trial. Diabetes Obesity And Metabolism 2023, 25: 3059-3063. PMID: 37312648, DOI: 10.1111/dom.15176.
P308 Strategies for the screening of glucose tolerance abnormalities and diabetes in people with cystic fibrosis: a French position statementWeiss L, Reix P, Mosnier-Pudar H, Ronsin O, Beltrand J, Reynaud Q, Mely L, Burgel P, Stremler N, Rakotoarisoa L, Galderisi A, Perge K, Bendelac N, Abely M, Kessler L. P308 Strategies for the screening of glucose tolerance abnormalities and diabetes in people with cystic fibrosis: a French position statement. Journal Of Cystic Fibrosis 2023, 22: s158-s159. DOI: 10.1016/s1569-1993(23)00678-1.
Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approachValerio E, Stocchero M, Pirillo P, D’Errico I, Bonadies L, Galderisi A, Giordano G, Baraldi E. Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach. EBioMedicine 2023, 92: 104636. PMID: 37257315, PMCID: PMC10244906, DOI: 10.1016/j.ebiom.2023.104636.
In silico design and validation of a time-varying PID controller for an artificial pancreas with intraperitoneal insulin delivery and glucose sensingLibera A, Toffanin C, Drecogna M, Galderisi A, Pillonetto G, Cobelli C. In silico design and validation of a time-varying PID controller for an artificial pancreas with intraperitoneal insulin delivery and glucose sensing. APL Bioengineering 2023, 7: 026105. PMID: 37229215, PMCID: PMC10205143, DOI: 10.1063/5.0145446.
Beta cell function in the early stages of type 1 diabetes: still a long way ahead of usGalderisi A. Beta cell function in the early stages of type 1 diabetes: still a long way ahead of us. Pediatric Endocrinology Diabetes And Metabolism 2023, 29: 1-3. PMID: 37218722, PMCID: PMC10226454, DOI: 10.5114/pedm.2023.126360.
Screening strategies for glucose tolerance abnormalities and diabetes in people with cystic fibrosisWeiss L, Reix P, Mosnier-Pudar H, Ronsin O, Beltrand J, Reynaud Q, Mely L, Burgel P, Stremler N, Rakotoarisoa L, Galderisi A, Perge K, Bendelac N, Abely M, Kessler L. Screening strategies for glucose tolerance abnormalities and diabetes in people with cystic fibrosis. Diabetes & Metabolism 2023, 49: 101444. PMID: 37030530, DOI: 10.1016/j.diabet.2023.101444.
Answering clinically pertinent questions with real-world data from paediatric type 1 diabetes registriesGalderisi A, Sherr J. Answering clinically pertinent questions with real-world data from paediatric type 1 diabetes registries. The Lancet Diabetes & Endocrinology 2023, 11: 300-301. PMID: 37004711, DOI: 10.1016/s2213-8587(23)00085-2.
Clinical features of neonatal COVID-19Galderisi A, Lista G, Cavigioli F, Trevisanuto D. Clinical features of neonatal COVID-19. Seminars In Fetal And Neonatal Medicine 2023, 28: 101430. PMID: 37005209, PMCID: PMC10036147, DOI: 10.1016/j.siny.2023.101430.
A New Index of Insulin Sensitivity from Glucose Sensor and Insulin Pump Data: In Silico and In Vivo Validation in Youths with Type 1 DiabetesSchiavon M, Galderisi A, Basu A, Kudva Y, Cengiz E, Man C. A New Index of Insulin Sensitivity from Glucose Sensor and Insulin Pump Data: In Silico and In Vivo Validation in Youths with Type 1 Diabetes. Diabetes Technology & Therapeutics 2023, 25: 270-278. PMID: 36648253, PMCID: PMC10066780, DOI: 10.1089/dia.2022.0397.
Early treatment of neonatal diabetes with oral glibenclamide in an extremely preterm infantGalderisi A, Kermorvant‐Duchemin E, Daruich A, Bonnard A, Lapillonne A, Aubelle M, Perrella B, Vial Y, Cave H, Berdugo M, Jarreau P, Polak M, Beltrand J. Early treatment of neonatal diabetes with oral glibenclamide in an extremely preterm infant. 2023, 64: 161-166. PMID: 36873092, PMCID: PMC9981413, DOI: 10.1002/jmd2.12358.
Obstructive sleep apnea (OSA) is associated with the impairment of beta-cell response to glucose in children and adolescents with obesityUmano G, Galderisi A, Aiello F, Martino M, Camponesco O, Di Sessa A, Marzuillo P, Alfonso P, Miraglia del Giudice E. Obstructive sleep apnea (OSA) is associated with the impairment of beta-cell response to glucose in children and adolescents with obesity. International Journal Of Obesity 2023, 47: 257-262. PMID: 36670156, PMCID: PMC10113157, DOI: 10.1038/s41366-023-01257-w.
Dépistage des anomalies de la tolérance au glucose et du diabète de mucoviscidose. Position de la Société française de la mucoviscidose (SFM), de la Société francophone du diabète (SFD) et de la Société française d’endocrinologie et diabétologie pédiatrique (SFEDP)Weiss L, Reix P, Mosnier-Pudar H, Ronsin O, Beltrand J, Reynaud Q, Mely L, Burgel P, Stremler N, Rakotoarisoa L, Galderisi A, Perge K, Bendelac N, Abely M, Kessler L. Dépistage des anomalies de la tolérance au glucose et du diabète de mucoviscidose. Position de la Société française de la mucoviscidose (SFM), de la Société francophone du diabète (SFD) et de la Société française d’endocrinologie et diabétologie pédiatrique (SFEDP). Médecine Des Maladies Métaboliques 2023, 17: 169-188. DOI: 10.1016/j.mmm.2023.01.001.
β-Cell Function and Insulin Sensitivity in Youth With Early Type 1 Diabetes From a 2-Hour 7-Sample OGTTGalderisi A, Evans-Molina C, Martino M, Caprio S, Cobelli C, Moran A. β-Cell Function and Insulin Sensitivity in Youth With Early Type 1 Diabetes From a 2-Hour 7-Sample OGTT. The Journal Of Clinical Endocrinology & Metabolism 2022, 108: 1376-1386. PMID: 36546354, PMCID: PMC10188312, DOI: 10.1210/clinem/dgac740.
Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational studyGalderisi A, Tordin M, Suppiej A, Cainelli E, Baraldi E, Trevisanuto D. Glucose-to-lactate ratio and neurodevelopment in infants with hypoxic-ischemic encephalopathy: an observational study. European Journal Of Pediatrics 2022, 182: 837-844. PMID: 36484862, PMCID: PMC9899169, DOI: 10.1007/s00431-022-04694-3.
Adipose Tissue Insulin Resistance Is Not Associated With Changes in the Degree of Obesity in Children and Adolescents.Halloun R, Galderisi A, Caprio S, Weiss R. Adipose Tissue Insulin Resistance Is Not Associated With Changes in the Degree of Obesity in Children and Adolescents. The Journal Of Clinical Endocrinology & Metabolism 2022, 108: 1053-1060. PMID: 36469736, PMCID: PMC10306082, DOI: 10.1210/clinem/dgac700.
ISPAD Clinical Practice Consensus Guidelines 2022: Diabetes technologies: Insulin deliverySherr J, Schoelwer M, Dos Santos T, Reddy L, Biester T, Galderisi A, van Dyk J, Hilliard M, Berget C, DiMeglio L. ISPAD Clinical Practice Consensus Guidelines 2022: Diabetes technologies: Insulin delivery. Pediatric Diabetes 2022, 23: 1406-1431. PMID: 36468192, DOI: 10.1111/pedi.13421.
Neonatal Hyperglycemia and Neurodevelopmental Outcomes in Preterm Infants: A ReviewGuiducci S, Meggiolaro L, Righetto A, Piccoli M, Baraldi E, Galderisi A. Neonatal Hyperglycemia and Neurodevelopmental Outcomes in Preterm Infants: A Review. Children 2022, 9: 1541. PMID: 36291477, PMCID: PMC9600957, DOI: 10.3390/children9101541.
Glucose variability increases during minimally invasive procedures in very preterm infantsGalderisi A, Res G, Guiducci S, Savio F, Brigadoi S, Forlani L, Mastrandrea B, Moschino L, Lolli E, Priante E, Trevisanuto D, Baraldi E. Glucose variability increases during minimally invasive procedures in very preterm infants. European Journal Of Pediatrics 2022, 182: 89-94. PMID: 36201017, PMCID: PMC9829573, DOI: 10.1007/s00431-022-04641-2.
Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infantsA G, D T, C R, R H, M B. Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants. 2022 DOI: 10.1530/ey.19.2.4.
Mechanistic Insights Into the Heterogeneity of Glucose Response Classes in Youths With Obesity: A Latent Class Trajectory ApproachTricò D, McCollum S, Samuels S, Santoro N, Galderisi A, Groop L, Caprio S, Shabanova V. Mechanistic Insights Into the Heterogeneity of Glucose Response Classes in Youths With Obesity: A Latent Class Trajectory Approach. Diabetes Care 2022, 45: 1841-1851. PMID: 35766976, PMCID: PMC9346992, DOI: 10.2337/dc22-0110.
SGLT2i Improves Glycemic Control in Patients With Congenital Severe Insulin Resistance.Galderisi A, Tamborlane W, Taylor SI, Attia N, Moretti C, Barbetti F. SGLT2i Improves Glycemic Control in Patients With Congenital Severe Insulin Resistance. Pediatrics 2022, 150 PMID: 35652305, DOI: 10.1542/peds.2021-055671.
342-OR: Low Incretin Effect Is Associated with Longitudinal Decline of Beta-Cell Function and Insulin Sensitivity in Obese YouthGALDERISI A, LAT J, SAMUELS S, PIERPONT B, VAN NAME M, SANTORO N, CAPRIO S. 342-OR: Low Incretin Effect Is Associated with Longitudinal Decline of Beta-Cell Function and Insulin Sensitivity in Obese Youth. Diabetes 2022, 71 DOI: 10.2337/db22-342-or.
A low n‐6 to n‐3 polyunsaturated fatty acid ratio diet improves hyperinsulinaemia by restoring insulin clearance in obese youthTricò D, Galderisi A, Van Name MA, Caprio S, Samuels S, Li Z, Galuppo BT, Savoye M, Mari A, Feldstein AE, Santoro N. A low n‐6 to n‐3 polyunsaturated fatty acid ratio diet improves hyperinsulinaemia by restoring insulin clearance in obese youth. Diabetes Obesity And Metabolism 2022, 24: 1267-1276. PMID: 35297549, PMCID: PMC9177628, DOI: 10.1111/dom.14695.
Pediatric Preventive Care in Middle-High Resource Countries—The Padova Chart for Health in ChildrenGalderisi A, Perilongo G, Caprio S, Da Dalt L, Di Salvo G, Gatta M, Giaquinto C, Rizzuto R, Robb A, Sly PD, Simonelli A, Staiano A, Vettor R, Baraldi E. Pediatric Preventive Care in Middle-High Resource Countries—The Padova Chart for Health in Children. Frontiers In Pediatrics 2022, 10: 803323. PMID: 35498805, PMCID: PMC9047691, DOI: 10.3389/fped.2022.803323.
Lack of Evidence for a Causal Role of Hyperinsulinemia in the Progression of Obesity in Children and Adolescents: A Longitudinal Study.Halloun R, Galderisi A, Caprio S, Weiss R. Lack of Evidence for a Causal Role of Hyperinsulinemia in the Progression of Obesity in Children and Adolescents: A Longitudinal Study. Diabetes Care 2022, 45: 1400-1407. PMID: 35235641, PMCID: PMC9210872, DOI: 10.2337/dc21-2210.
Intraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental ModelingPresti J, Galderisi A, Doyle F, Zisser H, Dassau E, Renard E, Toffanin C, Cobelli C. Intraperitoneal Insulin Delivery: Evidence of a Physiological Route for Artificial Pancreas From Compartmental Modeling. Journal Of Diabetes Science And Technology 2022, 17: 751-756. PMID: 35144503, PMCID: PMC10210098, DOI: 10.1177/19322968221076559.
Inhibition of 11β‐Hydroxysteroid dehydrogenase‐1 with AZD4017 in patients with nonalcoholic steatohepatitis or nonalcoholic fatty liver disease: A randomized, double‐blind, placebo‐controlled, phase II studyYadav Y, Dunagan K, Khot R, Venkatesh S, Port J, Galderisi A, Cobelli C, Wegner C, Basu A, Carter R, Basu R. Inhibition of 11β‐Hydroxysteroid dehydrogenase‐1 with AZD4017 in patients with nonalcoholic steatohepatitis or nonalcoholic fatty liver disease: A randomized, double‐blind, placebo‐controlled, phase II study. Diabetes Obesity And Metabolism 2022, 24: 881-890. PMID: 35014156, PMCID: PMC9135169, DOI: 10.1111/dom.14646.
The BabyGlucoLight Project: Understanding the Impact of Neonatal Glycemic Control on Brain Hemodynamics and Developmental Outcome in Very Preterm NeonatesBrigadoi S, Galderisi A, Guiducci S, Cusinato M, Res G, Avagliano L, Sandonà A, Savio F, Di Giorgio E, Priante E, Baraldi E. The BabyGlucoLight Project: Understanding the Impact of Neonatal Glycemic Control on Brain Hemodynamics and Developmental Outcome in Very Preterm Neonates. 2022, otu4d.2. DOI: 10.1364/ots.2022.otu4d.2.
Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infantsGalderisi A, Trevisanuto D, Russo C, Hall R, Bruschettini M. Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants. Cochrane Database Of Systematic Reviews 2021, 2021: cd013309. PMID: 34931697, PMCID: PMC8690212, DOI: 10.1002/14651858.cd013309.pub3.
Relation of glomerular filtration to insulin resistance and related risk factors in obese childrenMagen D, Halloun R, Galderisi A, Caprio S, Weiss R. Relation of glomerular filtration to insulin resistance and related risk factors in obese children. International Journal Of Obesity 2021, 46: 374-380. PMID: 34725443, DOI: 10.1038/s41366-021-01001-2.
Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infantsA G, M B, C R, R H, D T. Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants. 2021 DOI: 10.1530/ey.18.2.1.
Noncommunicable diseases of prematurity: Time for a new mindset?Baraldi E, Galderisi A. Noncommunicable diseases of prematurity: Time for a new mindset? The Journal Of Pediatrics 2021, 237: 319-320. PMID: 34197887, DOI: 10.1016/j.jpeds.2021.06.064.
206-LB: Indian Americans as Compared with Indians Exhibit Increased Beta-Cell Responsivity and Insulin Clearance in Absence of Changes in Insulin SensitivityPURANDARE V, GALDERISI A, MAERTINO M, BASU A, COBELLI C, UNNIKRISHNAN A, BASU R. 206-LB: Indian Americans as Compared with Indians Exhibit Increased Beta-Cell Responsivity and Insulin Clearance in Absence of Changes in Insulin Sensitivity. Diabetes 2021, 70 DOI: 10.2337/db21-206-lb.
67-OR: Oral Minimal Model Testing Reveals Early Impairment of Insulin Sensitivity in Type 1 Diabetes Autoantibody Positive, Nonobese, Nondysglycemic YouthGALDERISI A, MORAN A, EVANS-MOLINA C, MARTINO M, SANTORO N, CAPRIO S, COBELLI C. 67-OR: Oral Minimal Model Testing Reveals Early Impairment of Insulin Sensitivity in Type 1 Diabetes Autoantibody Positive, Nonobese, Nondysglycemic Youth. Diabetes 2021, 70 DOI: 10.2337/db21-67-or.
Early Impairment of Insulin Sensitivity, β-Cell Responsiveness, and Insulin Clearance in Youth with Stage 1 Type 1 DiabetesGalderisi A, Moran A, Evans-Molina C, Martino M, Santoro N, Caprio S, Cobelli C. Early Impairment of Insulin Sensitivity, β-Cell Responsiveness, and Insulin Clearance in Youth with Stage 1 Type 1 Diabetes. The Journal Of Clinical Endocrinology & Metabolism 2021, 106: 2660-2669. PMID: 34000022, PMCID: PMC8372628, DOI: 10.1210/clinem/dgab344.
Prevalence of psoriasis in a cohort of children and adolescents with type 1 diabetesCaroppo F, Galderisi A, Moretti C, Ventura L, Fortina A. Prevalence of psoriasis in a cohort of children and adolescents with type 1 diabetes. Journal Of The European Academy Of Dermatology And Venereology 2021, 35: e589-e591. PMID: 33914987, DOI: 10.1111/jdv.17318.
Metabolic syndrome and insulin resistance in pre-pubertal children with psoriasisCaroppo F, Galderisi A, Ventura L, Belloni Fortina A. Metabolic syndrome and insulin resistance in pre-pubertal children with psoriasis. European Journal Of Pediatrics 2021, 180: 1739-1745. PMID: 33483797, PMCID: PMC8105196, DOI: 10.1007/s00431-020-03924-w.
The aftermath of SARS-CoV-2 in NICU: saving or checking accounts? Projected cost-effectiveness analysisGalderisi A, Lolli E, Cavicchiolo M, Bonadies L, Trevisanuto D, Baraldi E. The aftermath of SARS-CoV-2 in NICU: saving or checking accounts? Projected cost-effectiveness analysis. European Journal Of Pediatrics 2021, 180: 1631-1635. PMID: 33415468, PMCID: PMC7790311, DOI: 10.1007/s00431-020-03884-1.
Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infantsGalderisi A, Bruschettini M, Russo C, Hall R, Trevisanuto D. Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants. Cochrane Database Of Systematic Reviews 2020, 12: cd013309. PMID: 33348448, PMCID: PMC8092644, DOI: 10.1002/14651858.cd013309.pub2.
Protecting youth from the vaping epidemicGalderisi A, Ferraro V, Caserotti M, Quareni L, Perilongo G, Baraldi E. Protecting youth from the vaping epidemic. Pediatric Allergy And Immunology 2020, 31: 66-68. PMID: 33236441, DOI: 10.1111/pai.13348.
Fatty liver, irrespective of ethnicity, is associated with reduced insulin clearance and insulin resistance in obese youthsTrico D, Galderisi A, Galuppo B, Pierpont B, Samuels S, Santoro N, Caprio S. Fatty liver, irrespective of ethnicity, is associated with reduced insulin clearance and insulin resistance in obese youths. Endocrine Abstracts 2020 DOI: 10.1530/endoabs.70.aep256.
A Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese YouthGalderisi A, Tricò D, Pierpont B, Shabanova V, Samuels S, Man C, Galuppo B, Santoro N, Caprio S. A Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese Youth. Diabetes Care 2020, 43: 2553-2563. PMID: 32788279, PMCID: PMC7510033, DOI: 10.2337/dc20-0445.
Effect of Afrezza on Glucose Dynamics During HCL TreatmentGalderisi A, Cohen N, Calhoun P, Kraemer K, Breton M, Weinzimer S, Cengiz E. Effect of Afrezza on Glucose Dynamics During HCL Treatment. Diabetes Care 2020, 43: 2146-2152. PMID: 32661108, PMCID: PMC7440894, DOI: 10.2337/dc20-0091.
978-P: Omnipod Personalized MPC Algorithm at Target Glucose of 110mg/dl Is Safe in Adults and Adolescents without Increasing Risk of HypoglycemiaFORLENZA G, BUCKINGHAM B, SHERR J, WADWA R, GALDERISI A, EKHLASPOUR L, BERGET C, HSU L, ZGORSKI M, LEE J, OCONNOR J, DUMAIS B, VIENNEAU T, HUYETT L, LY T. 978-P: Omnipod Personalized MPC Algorithm at Target Glucose of 110mg/dl Is Safe in Adults and Adolescents without Increasing Risk of Hypoglycemia. Diabetes 2020, 69 DOI: 10.2337/db20-978-p.
1296-P: Omnipod Personalized MPC Algorithm at Target Glucose of 110mg/dl Is Safe in Children Aged 2-12 Years without Increasing Risk of HypoglycemiaSHERR J, BUCKINGHAM B, FORLENZA G, GALDERISI A, EKHLASPOUR L, WADWA R, ZGORSKI M, KINGMAN R, BERGET C, LEE J, OCONNOR J, DUMAIS B, VIENNEAU T, HUYETT L, LY T. 1296-P: Omnipod Personalized MPC Algorithm at Target Glucose of 110mg/dl Is Safe in Children Aged 2-12 Years without Increasing Risk of Hypoglycemia. Diabetes 2020, 69 DOI: 10.2337/db20-1296-p.
61-OR: Genetic and Metabolic Determinants of the Incretin Effect in Obese Adolescent with PrediabetesGALDERISI A, SAMUELS S, PIERPONT B, MAN C, SANTORO N, CAPRIO S. 61-OR: Genetic and Metabolic Determinants of the Incretin Effect in Obese Adolescent with Prediabetes. Diabetes 2020, 69 DOI: 10.2337/db20-61-or.
Intrahepatic fat, irrespective of ethnicity, is associated with reduced endogenous insulin clearance and hepatic insulin resistance in obese youths: A cross‐sectional and longitudinal study from the Yale Pediatric NAFLD cohortTricò D, Galderisi A, Mari A, Polidori D, Galuppo B, Pierpont B, Samuels S, Santoro N, Caprio S. Intrahepatic fat, irrespective of ethnicity, is associated with reduced endogenous insulin clearance and hepatic insulin resistance in obese youths: A cross‐sectional and longitudinal study from the Yale Pediatric NAFLD cohort. Diabetes Obesity And Metabolism 2020, 22: 1628-1638. PMID: 32363679, PMCID: PMC8174801, DOI: 10.1111/dom.14076.
Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study.Galderisi A, Tricò D, Dalla Man C, Santoro N, Pierpont B, Groop L, Cobelli C, Caprio S. Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study. The Journal Of Clinical Endocrinology & Metabolism 2020, 105: 534-542. PMID: 31972003, PMCID: PMC6977541, DOI: 10.1210/clinem/dgz207.
Safety and Performance of the Omnipod Hybrid Closed-Loop System in Adults, Adolescents, and Children with Type 1 Diabetes Over 5 Days Under Free-Living ConditionsSherr J, Buckingham BA, Forlenza G, Galderisi A, Ekhlaspour L, Wadwa RP, Carria L, Hsu L, Berget C, Peyser TA, Lee JB, O'Connor J, Dumais B, Huyett L, Layne JE, Ly TT. Safety and Performance of the Omnipod Hybrid Closed-Loop System in Adults, Adolescents, and Children with Type 1 Diabetes Over 5 Days Under Free-Living Conditions. Diabetes Technology & Therapeutics 2019, 22: 174-184. PMID: 31596130, PMCID: PMC7047109, DOI: 10.1089/dia.2019.0286.
Lower Insulin Clearance Parallels a Reduced Insulin Sensitivity in Obese Youths and Is Associated With a Decline in β-Cell Function Over TimeGalderisi A, Polidori D, Weiss R, Giannini C, Pierpont B, Tricò D, Caprio S. Lower Insulin Clearance Parallels a Reduced Insulin Sensitivity in Obese Youths and Is Associated With a Decline in β-Cell Function Over Time. Diabetes 2019, 68: 2074-2084. PMID: 31399433, PMCID: PMC6804624, DOI: 10.2337/db19-0120.
A Technological Revolution: The Integration of New Treatments to Manage Type 1 Diabetes.Galderisi A, Sherr JL. A Technological Revolution: The Integration of New Treatments to Manage Type 1 Diabetes. Pediatric Annals 2019, 48: e311-e318. PMID: 31426099, DOI: 10.3928/19382359-20190725-03.
Mapping hemodynamic changes during hypoglycemia in the very preterm neonatal brain: preliminary resultsBrigadoi S, Galderisi A, Pieropan E, Cooper R, Cutini S, Baraldi E, Cobelli C, Dell'Acqua R, Sparacino G, Trevisanuto D. Mapping hemodynamic changes during hypoglycemia in the very preterm neonatal brain: preliminary results. Progress In Biomedical Optics And Imaging 2019, 11074: 110740e-110740e-3. DOI: 10.1117/12.2526974.
Neonatal Resuscitation: State of the ArtTrevisanuto D, Galderisi A. Neonatal Resuscitation: State of the Art. American Journal Of Perinatology 2019, 36: s29-s32. PMID: 31238355, DOI: 10.1055/s-0039-1691797.
1054-P: Insulin Sensitivity from Sensor and Pump Data in Youths with Type 1 Diabetes: Hybrid Closed-Loop ValidationSCHIAVON M, GALDERISI A, KRAEMER K, COBELLI C, MAN C, CENGIZ E. 1054-P: Insulin Sensitivity from Sensor and Pump Data in Youths with Type 1 Diabetes: Hybrid Closed-Loop Validation. Diabetes 2019, 68 DOI: 10.2337/db19-1054-p.
121-OR: Insulin Clearance Is an Independent Determinant of ß-Cell Cell Function in Obese YouthsGALDERISI A, TRICO D, GIANNINI C, SANTORO N, CAPRIO S, WEISS R. 121-OR: Insulin Clearance Is an Independent Determinant of ß-Cell Cell Function in Obese Youths. Diabetes 2019, 68 DOI: 10.2337/db19-121-or.
1317-P: Static, but Nondynamic, ß-Cell Responsiveness to Glucose Is Affected by the Risk Variant rs7903146 of TCF7L2 and Associated with a Delayed Time-to-Glucose-Peak in Obese YouthsGALDERISI A, TRICO D, MAN C, SIEBEL S, SANTORO N, PIERPONT B, COBELLI C, CAPRIO S. 1317-P: Static, but Nondynamic, ß-Cell Responsiveness to Glucose Is Affected by the Risk Variant rs7903146 of TCF7L2 and Associated with a Delayed Time-to-Glucose-Peak in Obese Youths. Diabetes 2019, 68 DOI: 10.2337/db19-1317-p.
1318-P: Fructose Consumption Contributes to Hyperinsulinemia in Obese Adolescents through a GLP-1-Mediated MechanismGALDERISI A, VAN NAME M, GIANNINI C, SAVOYE M, CAPRIO S. 1318-P: Fructose Consumption Contributes to Hyperinsulinemia in Obese Adolescents through a GLP-1-Mediated Mechanism. Diabetes 2019, 68 DOI: 10.2337/db19-1318-p.
215-OR: Safety and Performance of the Omnipod Hybrid Closed-Loop System in Young Children Aged 2-6 Years with Type 1 DiabetesBUCKINGHAM B, FORLENZA G, SHERR J, GALDERISI A, EKHLASPOUR L, LEE J, OCONNOR J, DUMAIS B, HUYETT L, LAYNE J, LY T. 215-OR: Safety and Performance of the Omnipod Hybrid Closed-Loop System in Young Children Aged 2-6 Years with Type 1 Diabetes. Diabetes 2019, 68 DOI: 10.2337/db19-215-or.
Airway Histopathology of Adolescent Survivors of Bronchopulmonary DysplasiaGalderisi A, Calabrese F, Fortarezza F, Abman S, Baraldi E. Airway Histopathology of Adolescent Survivors of Bronchopulmonary Dysplasia. The Journal Of Pediatrics 2019, 211: 215-218. PMID: 31076230, DOI: 10.1016/j.jpeds.2019.04.006.
Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infantsGalderisi A, Bruschettini M, Russo C, Hall R, Trevisanuto D. Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants. Cochrane Database Of Systematic Reviews 2019, 2019 PMCID: PMC6460241, DOI: 10.1002/14651858.cd013309.
Fructose Consumption Contributes to Hyperinsulinemia in Adolescents With Obesity Through a GLP-1-Mediated Mechanism.Galderisi A, Giannini C, Van Name M, Caprio S. Fructose Consumption Contributes to Hyperinsulinemia in Adolescents With Obesity Through a GLP-1-Mediated Mechanism. The Journal Of Clinical Endocrinology & Metabolism 2019, 104: 3481-3490. PMID: 30938760, PMCID: PMC6599430, DOI: 10.1210/jc.2019-00161.
Chapter 11 Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes Pathophysiologic Links and Potential ImplicationsGalderisi A, Martino M, Santoro N. Chapter 11 Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) and Type 2 Diabetes Pathophysiologic Links and Potential Implications. 2019, 91-99. DOI: 10.1016/b978-0-323-55138-0.00011-5.
The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing beta-Cell Function and Hepatic Insulin SensitivityC C, N S, L G, C D, C C, A G, R K, B P, M G, S C. The rs7903146 Variant in the TCF7L2 Gene Increases the Risk of Prediabetes/Type 2 Diabetes in Obese Adolescents by Impairing beta-Cell Function and Hepatic Insulin Sensitivity. 2018 DOI: 10.1530/ey.15.12.3.
Suppression of Ketogenesis in Type 1 Diabetes Is Not Delayed by SGLT2 Inhibitor TherapySIEBEL S, PATEL N, GALDERISI A, CARRIA L, TAMBORLANE W, SHERR J. Suppression of Ketogenesis in Type 1 Diabetes Is Not Delayed by SGLT2 Inhibitor Therapy. Diabetes 2018, 67 DOI: 10.2337/db18-117-lb.
Ethnicity and Common Genetic Variants Modulate Nonalcoholic Fatty Liver Disease (NAFLD) Metabolic Phenotype in Obese YouthTRICO D, CAPRIO S, UMANO G, GALDERISI A, MATA M, NOUWS J, PIERPONT B, KIM G, SANTORO N. Ethnicity and Common Genetic Variants Modulate Nonalcoholic Fatty Liver Disease (NAFLD) Metabolic Phenotype in Obese Youth. Diabetes 2018, 67 DOI: 10.2337/db18-313-or.
The TCF7L2 Variant rs7903146 Affects the Risk of Youth-Onset Type 2 Diabetes by Reducing the Incretin Effect on Insulin SecretionGALDERISI A, PIERPONT B, D'ALESSIO D, SANTORO N, CAPRIO S. The TCF7L2 Variant rs7903146 Affects the Risk of Youth-Onset Type 2 Diabetes by Reducing the Incretin Effect on Insulin Secretion. Diabetes 2018, 67 DOI: 10.2337/db18-340-or.
The distance between the delivery room and neonatal intensive care unit had no impact on the respiratory management of preterm infants at birthTrevisanuto D, Morassutti F, Doglioni N, Avilés C, Galderisi A, Cavallin F. The distance between the delivery room and neonatal intensive care unit had no impact on the respiratory management of preterm infants at birth. Acta Paediatrica 2017, 107: 171-172. PMID: 28981170, DOI: 10.1111/apa.14107.
Metabolomics reveals new metabolic perturbations in children with type 1 diabetesGalderisi A, Pirillo P, Moret V, Stocchero M, Gucciardi A, Perilongo G, Moretti C, Monciotti C, Giordano G, Baraldi E. Metabolomics reveals new metabolic perturbations in children with type 1 diabetes. Pediatric Diabetes 2017, 19: 59-67. PMID: 28401628, DOI: 10.1111/pedi.12524.
Fish Oil in Pregnancy and Asthma in Offspring.Baraldi E, Galderisi A. Fish Oil in Pregnancy and Asthma in Offspring. New England Journal Of Medicine 2017, 376: 1191. PMID: 28328329, DOI: 10.1056/nejmc1701020.
A Telemonitoring Service Supporting Preterm Newborns Care in a Neonatal Intensive Care UnitLosiouk E, Lanzola G, Galderisi A, Trevisanuto D, Steil G, Facchinetti A, Cobelli C. A Telemonitoring Service Supporting Preterm Newborns Care in a Neonatal Intensive Care Unit. 2017, 1-6. DOI: 10.1109/rtsi.2017.8065890.
Long-term continuous monitoring of the preterm brain with diffuse optical tomography and electroencephalography: a technical note on cap manufacturingGalderisi A, Brigadoi S, Cutini S, Moro S, Lolli E, Meconi F, Benavides-Varela S, Baraldi E, Amodio P, Cobelli C, Trevisanuto D, Dell’Acqua R. Long-term continuous monitoring of the preterm brain with diffuse optical tomography and electroencephalography: a technical note on cap manufacturing. Neurophotonics 2016, 3: 045009-045009. PMID: 28042587, PMCID: PMC5180615, DOI: 10.1117/1.nph.3.4.045009.
High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004–2013Cherubini V, Skrami E, Ferrito L, Zucchini S, Scaramuzza A, Bonfanti R, Buono P, Cardella F, Cauvin V, Chiari G, d′Annunzio G, Frongia A, Iafusco D, Patera I, Toni S, Tumini S, Rabbone I, Lombardo F, Carle F, Gesuita R, Lera R, De Luna L, Gualtieri A, Zecchino C, Piccinno E, Reinstadler P, Prandi E, Gallo F, Morganti G, Ripoli C, La Loggia A, Scanu P, Cardinale G, Tomaselli L, Citriniti F, Lazzaro N, De Donno V, Mainetti B, Coccioli M, Maccioni R, Marongiu U, Bruzzese M, Iannilli A, Pardi D, Confetto S, Zanfardino A, Iughetti L, Franzese A, Cadario F, Milia A, Piredda G, Soro M, Correddu A, Galderisi A, De Berardinis F, Federico G, Zanette G, Suprani T, Pedini A, Bitti M, Delvecchio M, Trada M, Meloni G, Gaiero A, Bulciolu P, Guerraggio L, Faleschini E, Zanatta M, Salvatoni A, Maffeis C, Arnaldi C. High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004–2013. Scientific Reports 2016, 6: 38844. PMID: 27991500, PMCID: PMC5171855, DOI: 10.1038/srep38844.
Remote Blood Glucose Monitoring in mHealth Scenarios: A ReviewLanzola G, Losiouk E, Del Favero S, Facchinetti A, Galderisi A, Quaglini S, Magni L, Cobelli C. Remote Blood Glucose Monitoring in mHealth Scenarios: A Review. Sensors 2016, 16: 1983. PMID: 27886122, PMCID: PMC5190964, DOI: 10.3390/s16121983.
Evaluating the Experience of Children With Type 1 Diabetes and Their Parents Taking Part in an Artificial Pancreas Clinical Trial Over Multiple Days in a Diabetes Camp SettingTroncone A, Bonfanti R, Iafusco D, Rabbone I, Sabbion A, Schiaffini R, Galderisi A, Marigliano M, Rapini N, Rigamonti A, Tinti D, Vallone V, Zanfardino A, Boscari F, Del Favero S, Galasso S, Lanzola G, Messori M, Di Palma F, Visentin R, Calore R, Leal Y, Magni L, Losiouk E, Chernavvsky D, Quaglini S, Cobelli C, Bruttomesso D. Evaluating the Experience of Children With Type 1 Diabetes and Their Parents Taking Part in an Artificial Pancreas Clinical Trial Over Multiple Days in a Diabetes Camp Setting. Diabetes Care 2016, 39: 2158-2164. PMID: 27852685, DOI: 10.2337/dc16-1073.
Randomized Summer Camp Crossover Trial in 5- to 9-Year-Old Children: Outpatient Wearable Artificial Pancreas Is Feasible and SafeDel Favero S, Boscari F, Messori M, Rabbone I, Bonfanti R, Sabbion A, Iafusco D, Schiaffini R, Visentin R, Calore R, Moncada Y, Galasso S, Galderisi A, Vallone V, Di Palma F, Losiouk E, Lanzola G, Tinti D, Rigamonti A, Marigliano M, Zanfardino A, Rapini N, Avogaro A, Chernavvsky D, Magni L, Cobelli C, Bruttomesso D. Randomized Summer Camp Crossover Trial in 5- to 9-Year-Old Children: Outpatient Wearable Artificial Pancreas Is Feasible and Safe. Diabetes Care 2016, 39: 1180-1185. PMID: 27208335, DOI: 10.2337/dc15-2815.
The long-term treatment of a patient with type 1 diabetes mellitus and glutaric aciduria type 1: the effect of insulinDel Rizzo M, Galderisi A, Celato A, Furlan F, Giordano L, Cazzorla C, Fasan I, Moretti C, Zschocke J, Burlina A. The long-term treatment of a patient with type 1 diabetes mellitus and glutaric aciduria type 1: the effect of insulin. European Journal Of Pediatrics 2016, 175: 1123-1128. PMID: 26847429, DOI: 10.1007/s00431-016-2699-5.
Case Report: When an Induced Illness Looks Like a Rare DiseaseRabbone I, Galderisi A, Tinti D, Ignaccolo M, Barbetti F, Cerutti F. Case Report: When an Induced Illness Looks Like a Rare Disease. Pediatrics 2015, 136: e1361-e1365. PMID: 26438710, DOI: 10.1542/peds.2014-4165.
Cardiac Autoimmunity as a Novel Biomarker, Mediator, and Therapeutic Target of Heart Disease in Type 1 DiabetesLipes M, Galderisi A. Cardiac Autoimmunity as a Novel Biomarker, Mediator, and Therapeutic Target of Heart Disease in Type 1 Diabetes. Current Diabetes Reports 2015, 15: 30. PMID: 25821130, PMCID: PMC4376963, DOI: 10.1007/s11892-015-0598-1.
i-gel: a new supraglottic device for effective resuscitation of a very low birthweight infant with Cornelia de Lange syndromeGalderisi A, De Bernardo G, Lorenzon E, Trevisanuto D. i-gel: a new supraglottic device for effective resuscitation of a very low birthweight infant with Cornelia de Lange syndrome. BMJ Case Reports 2015, 2015: bcr2014209124. PMID: 25809435, PMCID: PMC4386302, DOI: 10.1136/bcr-2014-209124.
Autoantibodies and type 1 diabetes: are we still in the cave of an ancient myth?Galderisi A. Autoantibodies and type 1 diabetes: are we still in the cave of an ancient myth? Diabetologia 2014, 57: 1502-1503. PMID: 24838679, DOI: 10.1007/s00125-014-3261-5.
An easy, fast, effective tool to monitor the incidence of type 1 diabetes among children aged 0–4 years in Italy: the Italian Hospital Discharge Registry (IHDR)Vichi M, Iafusco D, Galderisi A, Stazi M, Nisticò L. An easy, fast, effective tool to monitor the incidence of type 1 diabetes among children aged 0–4 years in Italy: the Italian Hospital Discharge Registry (IHDR). Acta Diabetologica 2014, 51: 287-294. PMID: 24473635, DOI: 10.1007/s00592-014-0556-4.
The revolving door of ‘residual beta cell function’: cause or effect in medical reports?Galderisi A. The revolving door of ‘residual beta cell function’: cause or effect in medical reports? Diabetologia 2013, 57: 643-644. PMID: 24337157, DOI: 10.1007/s00125-013-3144-1.
Six cases with severe insulin resistance (SIR) associated with mutations of insulin receptor: Is a Bartter-like syndrome a feature of congenital SIR?Grasso V, Colombo C, Favalli V, Galderisi A, Rabbone I, Gombos S, Bonora E, Massa O, Meschi F, Cerutti F, Iafusco D, Bonfanti R, Monciotti C, Barbetti F. Six cases with severe insulin resistance (SIR) associated with mutations of insulin receptor: Is a Bartter-like syndrome a feature of congenital SIR? Acta Diabetologica 2013, 50: 951-957. PMID: 23824322, DOI: 10.1007/s00592-013-0490-x.
Emerging Effects of Early Environmental Factors over Genetic Background for Type 1 Diabetes Susceptibility: Evidence from a Nationwide Italian Twin StudyNisticò L, Iafusco D, Galderisi A, Fagnani C, Cotichini R, Toccaceli V, Stazi M. Emerging Effects of Early Environmental Factors over Genetic Background for Type 1 Diabetes Susceptibility: Evidence from a Nationwide Italian Twin Study. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: e1483-e1491. PMID: 22569240, DOI: 10.1210/jc.2011-3457.
Mitochondrial Diabetes in Children: Seek and You Will Find ItMazzaccara C, Iafusco D, Liguori R, Ferrigno M, Galderisi A, Vitale D, Simonelli F, Landolfo P, Prisco F, Masullo M, Sacchetti L. Mitochondrial Diabetes in Children: Seek and You Will Find It. PLOS ONE 2012, 7: e34956. PMID: 22536343, PMCID: PMC3334935, DOI: 10.1371/journal.pone.0034956.
Do HPV vaccine genotypes agree with circulating HPV types?Tartaglia E, Iafusco D, Galderisi A, Mastrantonio P. Do HPV vaccine genotypes agree with circulating HPV types? The Lancet Infectious Diseases 2011, 11: 585-586. PMID: 21798460, DOI: 10.1016/s1473-3099(11)70201-8.
Chat Line for Adolescents with Type 1 Diabetes: A Useful Tool to Improve Coping with Diabetes: A 2-Year Follow-Up StudyIafusco D, Galderisi A, Nocerino I, Cocca A, Zuccotti G, Prisco F, Scaramuzza A. Chat Line for Adolescents with Type 1 Diabetes: A Useful Tool to Improve Coping with Diabetes: A 2-Year Follow-Up Study. Diabetes Technology & Therapeutics 2011, 13: 551-555. PMID: 21406010, DOI: 10.1089/dia.2010.0188.
All classifications not built on pathogenesis become inadequate sooner or laterIafusco D, Galderisi A, Lombardo F, Scaramuzza A, Tartaglia E, Cocca A, Giugliano R, Giugliano B, Sena T, Napoli A, Mastrantonio P, Stoppoloni F, Prisco F. All classifications not built on pathogenesis become inadequate sooner or later. Diabetologia 2011, 54: 1583-1584. PMID: 21400041, DOI: 10.1007/s00125-011-2113-9.
Not every child with diabetes needs insulinIafusco D, Scaramuzza A, Galderisi A, Cocca A, Giugliano R, Zuccotti G, Prisco F. Not every child with diabetes needs insulin. The BMJ 2010, 341: c6512. PMID: 21081621, DOI: 10.1136/bmj.c6512.

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Alfonso Galderisi, MD, PhD

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