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Clifford Bogue, MD

Waldemar Von Zedtwitz Professor of Pediatrics
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Additional Titles

Chair, Pediatrics

Chief of Pediatrics, Yale New Haven Health System

About

Yale Pediatrics transforms the health and well-being of children and adolescents by providing exceptional and equitable medical care, leading cutting-edge research, advocating for policies and resources that enable children and adolescents to lead healthier lives, and educating the next generation of diverse pediatric care providers and thought leaders.

Titles

Waldemar Von Zedtwitz Professor of Pediatrics

Chair, Pediatrics; Chief of Pediatrics, Yale New Haven Health System

Biography

Clifford W. Bogue, MD, a pediatric critical care specialist, is the Waldemar Von Zedtwitz Professor and Chairman of Pediatrics at Yale School of Medicine, where he has been on the faculty since 1993. He also serves as Chief of Pediatrics, Yale New Haven Health System. From 2014 to 2023 he served as the inaugural Chief Medical Officer of Yale-New Haven Children’s Hospital, where he provided strategic and operational leadership for the Children’s Hospital’s clinical delivery systems. Dr. Bogue was named Chairman of the Department of Pediatrics in August, 2017. Dr. Bogue received both his undergraduate and medical degrees from the University of Virginia (UVA). He was a resident and chief resident in pediatrics at Vanderbilt University before completing a fellowship in pediatric critical care medicine at Yale.

During his career at Yale, Dr. Bogue has held a number of medical school and hospital leadership positions, including Director of Pediatric Critical Care Transport, Medical Director of the Pediatric Intensive Care Unit, Director of the Pediatric Critical Care Fellowship, Chief of Pediatric Critical Care Medicine and Associate Chairman for Strategic Planning. From 2010-2012, he served as Interim Chairman of Pediatrics and Physician-in-Chief of Yale New Haven Children’s Hospital and from 2012-2015 served as Vice Chairman of the Department of Pediatrics. He served as Interim Chairman of Pediatrics from 2015-2017.

Dr. Bogue has been actively involved in training students, residents, and fellows and is committed to the development of pediatric physician-scientists. He was director of Bedside to Bench: Seminars in Pediatrics, a course for first-year medical students for over ten years, served on the MD/PhD Faculty Committee, was PI for an NIH T32 training program in cardiopulmonary development for 10 years. He most recently served as training director for the Yale Child Health Research Center, a K12 program funded by the NICHD that had 25 years of consecutive funding. He has served on several NIH peer review panels and is currently a member of the Child Health Research Scientific Review Committee of the Charles H. Hood Foundation. He previously served as Co-Chair of the American Heart Association Genetics/Epigenetics peer review committee. In 2014, Dr. Bogue was the Chair of the Planning Committee for Pediatric Clinical Trials Network Stakeholders’ Forum, a forum convened by the American Academy of Pediatrics to initiate the process of developing a global pediatric clinical trials network. Dr. Bogue served on two NIH Advisory Committees of the NIH focused on the inclusion of children in research and in the Precision Medicine Program Initiative All of Us.

Dr. Bogue’s academic career at Yale also included establishing and directing an NIH-funded research program in the developmental biology of the lung, liver, and cardiovascular system for over 20 years. During that time, his laboratory made important contributions to the genetic pathways involved in embryonic organ development, including the identification of genetic pathways critical to formation of the liver and biliary system as well as the cardiovascular system.

Dr. Bogue has served on a number of national and international boards in academic pediatrics including the Council of the Society for Pediatric Research, the Federation of Pediatric Organizations’ Child Health Research and Training Workgroup, and the Program Committee of the Pediatric Academic Societies’ Meeting where he served as Chair from 2015-2017. He also served previously as a Trustee and President of the International Pediatric Research Foundation (which is responsible for publishing the journal Pediatric Research), Secretary-Treasurer of the American Pediatric Society, Chair of the AAP Committee on Pediatric Research, and Section Editor for Current Opinion in Pediatrics. He was elected President of the American Pediatric Society for the 2024-2025 term He has been named annually to Best Doctors in America since 2004 and was awarded both the Mae Gailani Young Investigator and Norman J Siegel Faculty Awards at the Yale School of Medicine and the Marna P. Borgstrom Lifetime Achievement Award from the Friends of Yale New Haven Children’s Hospital.

Appointments

Other Departments & Organizations

Education & Training

Fellow
Yale University (1993)
Chief Resident
Vanderbilt University Medical Center (1989)
Resident
Vanderbilt University Medical Center (1988)
MD
University of Virginia (1985)
BA
University of Virginia (1981)

Research

Overview

The major focus of my research is to understand the molecular control of organ formation and cell-type specification. In particular, we are focusing on the role that homeobox genes play in early organogenesis, specifically the Hhex gene. Based on a null mutation of Hhex generated in my laboratory, we have determined that Hhex is crucial for early liver budding and morphogenesis, cardiovascular development, and lymphopoiesis. We plan to determine the precise role of Hhex in these critical developmental processes and the factors with which it interacts using mouse molecular genetics, conditional gene knockouts, and transgenic overexpression in specific cells and tissues. The two major areas of focus in the lab are the roles that Hhex plays in liver and cardiovascular development. By studying the specific role of Hhex during development, we will gain important insight into the basic developmental mechanisms involved in early organogenesis of a number of different organs. Ultimately, we plan to use the knowledge obtained by our study of the basic mechanisms of organ development to repair and regenerate organs and tissues in humans.

  • Hhex – a homeobox gene essential for liver development. In this project, we are using mice with a liver-specific deletion of Hhex, derived in my lab, to gain insight into liver cell differentiation and bile duct morphogenesis.
  • Mechanism of polycystic liver disease in Hhex mutant mice. In this project, we are studying the role that Hhex deletion in the embryonic liver leads to polycystic liver disease.
  • Hhex and cardiovascular development. Hhex is critically important for normal heart and blood vessel development. This project focuses on the molecular mechanisms by which embryonic cardiovascular development is dependent on normal Hhex levels.

Medical Subject Headings (MeSH)

Critical Care; Gastroenterology; Morphogenesis; Organogenesis; Pediatrics

Research at a Glance

Yale Co-Authors

Frequent collaborators of Clifford Bogue's published research.

Publications

2015

2014

2010

2008

2007

2001

2000

Academic Achievements & Community Involvement

  • honor

    M.A. privatim (Honorary)

  • honor

    Norman J Siegel Award - "To that member of the faculty who consistently displays high standards of patient care, generosity, collegiality and leadership"

  • honor

    Elected Member

  • honor

    Visiting Scholar

  • honor

    Senior Associate, King's College

Clinical Care

Overview

Clifford W. Bogue, MD, chair of pediatrics and chief medical officer at Yale New Haven Children’s Hospital, specializes in pediatric critical care. His research interests are focused on the early development of the liver and cardiovascular system. “I want to understand how organs develop so that I might use that knowledge someday to repair damaged organs in children,” he says.

Dr. Bogue established and directed and National Institutes of Health-funded research program in the developmental biology of the lung, liver and cardiovascular system for more than 20 years. During that time, his laboratory made important contributions to the genetic pathways involved in embryonic organ development. Dr. Bogue is a professor of pediatrics (critical care) at Yale School of Medicine and the interim chief for the Gastroenterology & Hepatology Section of Yale Medicine Department of Pediatrics.

He is a member of the American Pediatric Society and in 2013 was elected secretary-treasurer to the International Pediatric Research Foundation. Dr. Bogue also serves on the editorial board of the journal Current Opinion in Pediatrics.

Clinical Specialties

Pediatrics; Pediatric Critical Care Medicine

Board Certifications

  • Pediatric Critical Care Medicine

    Certification Organization
    AB of Pediatrics
    Latest Certification Date
    2016
    Original Certification Date
    1994

Yale Medicine News

Get In Touch

Contacts

Academic Office Number

Administrative Support

Locations

  • Pediatric Chair's Office

    Academic Office

    Laboratory for Medicine and Pediatrics (LMP)

    15 York Street, Ste LMP 4085

    New Haven, CT 06510

    Chair's Office

    203.785.4638
  • Patient Care Locations

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