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Research

Research is central to the mission of the Yale Department of Neurology. Advances in clinical care depend on understanding the fundamental mechanisms of nervous system disease and translating those discoveries into more effective diagnostic, preventive, and therapeutic strategies. Faculty in the Department pursue a broad and integrated research portfolio spanning molecular and cellular neuroscience, genetics and genomics, neuroimmunology, neurovascular biology, electrophysiology, systems neuroscience, computational neuroscience, imaging, pharmacology, and clinical investigation. These programs address major neurological disorders across the lifespan, including neurodegenerative disease, stroke and vascular cognitive impairment, epilepsy, neuromuscular disease, multiple sclerosis and other neuroimmunologic disorders, movement disorders, headache, neuro-oncology, and neurodevelopmental conditions. The Department is committed to bridging basic, translational, and clinical research. We actively promote collaboration among laboratory investigators, clinician-scientists, clinical trialists, computational scientists, and physician specialists to accelerate the movement of discoveries from the laboratory to patients and from clinical observation back to mechanistic investigation. Through this collaborative research environment, Yale Neurology faculty are advancing understanding of the nervous system, defining disease mechanisms, developing innovative technologies, and working toward new treatments for patients with neurological disease.

Clinical Research

Centers & Programs

National Neurology Research Network

StrokeNET: SPIRIT

SPIRIT (Southern New England Partnership in Stroke Research, Innovation and Treatment) was selected in 2018 by the National Institutes of Health (NIH) as one of approximately 25 U.S. sites designated to participate in StrokeNET. The primary goal of this network is to maximize efficiencies to develop, promote, and conduct high-quality, multi-site clinical trials focused on key interventions in stroke prevention, treatment, and recovery.