Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin
Kobayashi H, Liu Q, Binns TC, Urrutia AA, Davidoff O, Kapitsinou PP, Pfaff AS, Olauson H, Wernerson A, Fogo AB, Fong GH, Gross KW, Haase VH. Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. Journal Of Clinical Investigation 2016, 126: 1926-1938. PMID: 27088801, PMCID: PMC4855934, DOI: 10.1172/jci83551.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasic Helix-Loop-Helix Transcription FactorsErythropoietinForkhead Transcription FactorsHypoxiaHypoxia-Inducible Factor-Proline DioxygenasesKidneyMiceMice, KnockoutProcollagen-Proline DioxygenaseStromal CellsConceptsRenal interstitial cellsProlyl-4-hydroxylase domainInterstitial cellsRenal erythropoietinPHD2 inactivationPharmacologic PHD inhibitionHIF-2 activityDistinct subpopulationsHypoxia-inducible factor-2Interstitial fibroblast-like cellsFibroblast-like cellsRenal interstitiumPHD inhibitionStroma-derived cellsRenal EpoErythropoietinHeterozygous deficiencyEPO productionEPO synthesisFactor 2PHD3Cell plasticityCellular oxygen sensorsHypoxiaEPO induction