2024
Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys
Piotrowski-Daspit A, Bracaglia L, Eaton D, Richfield O, Binns T, Albert C, Gould J, Mortlock R, Egan M, Pober J, Saltzman W. Enhancing in vivo cell and tissue targeting by modulation of polymer nanoparticles and macrophage decoys. Nature Communications 2024, 15: 4247. PMID: 38762483, PMCID: PMC11102454, DOI: 10.1038/s41467-024-48442-7.Peer-Reviewed Original ResearchConceptsPoly(amine-co-esterPolymer nanoparticlesDelivery of nucleic acid therapeuticsCell-type tropismTissue tropismNucleic acid delivery vehiclesIn vivo deliveryIn vivo efficacyCirculation half-lifeNucleic acid therapeuticsVehicle characteristicsTunable propertiesBiodistribution assessmentPhysiological fatePolymer chemistrySurface propertiesPharmacokinetic modelTissue targetingNanoparticlesDistribution modifiersPolymeric nanoparticlesTropismPolymerDelivery vehiclesHalf-life
2016
Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin
Kobayashi H, Liu Q, Binns TC, Urrutia AA, Davidoff O, Kapitsinou PP, Pfaff AS, Olauson H, Wernerson A, Fogo AB, Fong GH, Gross KW, Haase VH. Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. Journal Of Clinical Investigation 2016, 126: 1926-1938. PMID: 27088801, PMCID: PMC4855934, DOI: 10.1172/jci83551.Peer-Reviewed Original ResearchConceptsRenal interstitial cellsProlyl-4-hydroxylase domainInterstitial cellsRenal erythropoietinPHD2 inactivationPharmacologic PHD inhibitionHIF-2 activityDistinct subpopulationsHypoxia-inducible factor-2Interstitial fibroblast-like cellsFibroblast-like cellsRenal interstitiumPHD inhibitionStroma-derived cellsRenal EpoErythropoietinHeterozygous deficiencyEPO productionEPO synthesisFactor 2PHD3Cell plasticityCellular oxygen sensorsHypoxiaEPO induction