2020
CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses
Lin T, Geng T, Harrison AG, Yang D, Vella AT, Fikrig E, Wang P. CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses. Viruses 2020, 12: 1252. PMID: 33147869, PMCID: PMC7692144, DOI: 10.3390/v12111252.Peer-Reviewed Original ResearchConceptsChikungunya virusAlphaviral arthritisArthritogenic alphavirusesLargest immune cell populationMacrophages/T cellsImmune cell populationsInflammatory immune responseLow viral loadWild-type miceO'nyong-nyong virusWild-type animalsRheumatic manifestationsImmune infiltratesViral loadT cellsImmune responseAlphaviral diseaseArthritic diseasesTherapeutic targetCXCL10PathogenesisViral RNACell populationsArthritisFootpad
2018
Daily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells
Silver AC, Buckley SM, Hughes ME, Hastings AK, Nitabach MN, Fikrig E. Daily oscillations in expression and responsiveness of Toll-like receptors in splenic immune cells. Heliyon 2018, 4: e00579. PMID: 29862343, PMCID: PMC5968137, DOI: 10.1016/j.heliyon.2018.e00579.Peer-Reviewed Original ResearchAdherent splenocytesToll-like receptor expressionMRNA levelsProtein levelsSplenic immune cellsToll-like receptorsDependent immune responsesZeitgeber time (ZT) 1Adherent cell populationDendritic cellsTLR3 ligandTLR ligandsCytokine expressionSplenocyte populationImmune cellsReceptor expressionImmune responseSplenic macrophagesB cellsRhythmic expressionCell populationsTLRSplenocytesDaily light-dark cycleCircadian rhythm