2021
Combined liver–cytokine humanization comes to the rescue of circulating human red blood cells
Song Y, Shan L, Gbyli R, Liu W, Strowig T, Patel A, Fu X, Wang X, Xu ML, Gao Y, Qin A, Bruscia EM, Tebaldi T, Biancon G, Mamillapalli P, Urbonas D, Eynon E, Gonzalez DG, Chen J, Krause DS, Alderman J, Halene S, Flavell RA. Combined liver–cytokine humanization comes to the rescue of circulating human red blood cells. Science 2021, 371: 1019-1025. PMID: 33674488, PMCID: PMC8292008, DOI: 10.1126/science.abe2485.Peer-Reviewed Original ResearchConceptsRed blood cellsBlood cellsHuman sickle cell diseaseSickle cell diseaseImmunodeficient murine modelKupffer cell densityBone marrow failureMISTRG miceIntrasplenic injectionSCD pathologyCell diseaseMurine modelComplement C3RBC survivalVivo modelHuman cytokinesPreclinical testingHematopoietic stem cellsHuman red blood cellsMarrow failureFumarylacetoacetate hydrolase geneHuman erythropoiesisHuman liverHuman hepatocytesMice
2009
Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction
Zhi G, Wilson JB, Chen X, Krause DS, Xiao Y, Jones NJ, Kupfer GM. Fanconi Anemia Complementation Group FANCD2 Protein Serine 331 Phosphorylation Is Important for Fanconi Anemia Pathway Function and BRCA2 Interaction. Cancer Research 2009, 69: 8775-8783. PMID: 19861535, PMCID: PMC5912675, DOI: 10.1158/0008-5472.can-09-2312.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBRCA2 ProteinCell LineCheckpoint Kinase 1DNA DamageFanconi AnemiaFanconi Anemia Complementation Group D2 ProteinFanconi Anemia Complementation Group ProteinsHumansImmunoblottingImmunoprecipitationMass SpectrometryPhosphorylationProtein KinasesSequence Homology, Amino AcidSerineSignal TransductionConceptsS-phase checkpoint kinaseFanconi anemia DNA repair pathwayFanconi anemia pathwayRegulatory phosphorylation eventsDNA repair pathwaysFANCD1/BRCA2Phosphomimetic mutationBRCA2 interactionsPhosphorylation eventsSerine 331Checkpoint kinaseCancer susceptibility syndromeComplementation groupsRepair pathwaysPathway functionFanconi anemiaBone marrow failurePhosphorylationDownstream playersVivo interactionS331Susceptibility syndromeMarrow failurePathwayMonoubiquitylation