2010
14-3-3 Regulates the Lnk/JAK2 Pathway In Hematopoietic Stem and Progenitor Cells
Balcerek J, Jiang J, Bersenev A, Song Y, Wu C, Tong W. 14-3-3 Regulates the Lnk/JAK2 Pathway In Hematopoietic Stem and Progenitor Cells. Blood 2010, 116: 86. DOI: 10.1182/blood.v116.21.86.86.Peer-Reviewed Original ResearchOncogenic JAK2HSPC expansionHematopoietic stemRegulation of JAK2Serine phosphorylation eventsTyrosine kinase JAK2Progenitor cell homeostasisLymphocyte adaptor proteinHSPC developmentPhosphorylation eventsAdaptor proteinScaffold proteinCellular processesSerine residuesKinase JAK2Lnk-/- miceGene productsCritical binding siteRegulatory mechanismsCell homeostasisHSPC homeostasisJAK2 activityInactive stateFunction mutationsJAK2 pathway
2009
Lnk Constrains Oncogenic JAK2-Induced Myeloproliferative Disease in Mice.
Bersenev A, Wu C, Balcerek J, Tong W. Lnk Constrains Oncogenic JAK2-Induced Myeloproliferative Disease in Mice. Blood 2009, 114: 1437. DOI: 10.1182/blood.v114.22.1437.1437.Peer-Reviewed Original ResearchOncogenic JAK2TPO stimulationHematopoietic stem cell homeostasisDownstream signal transduction pathwaysStem cell homeostasisAdaptor protein LNKSignal transduction pathwaysPhysiological negative regulatorCell surface receptorsImportant signaling axisWild-type bone marrow cellsDouble mutantTransduction pathwaysJAK2 activationHSC poolLNK deficiencyNegative regulatorJanus kinaseCell homeostasisCell developmentCytokine receptorsSignaling AxisJAK2 pathwayChromosomal translocationsMPD development