2021
Antibodies against human endogenous retrovirus K102 envelope activate neutrophils in systemic lupus erythematosus
Tokuyama M, Gunn BM, Venkataraman A, Kong Y, Kang I, Rakib T, Townsend MJ, Costenbader KH, Alter G, Iwasaki A. Antibodies against human endogenous retrovirus K102 envelope activate neutrophils in systemic lupus erythematosus. Journal Of Experimental Medicine 2021, 218: e20191766. PMID: 34019642, PMCID: PMC8144942, DOI: 10.1084/jem.20191766.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusNeutrophil extracellular trapsLupus erythematosusImmune complexesFormation of NETsEnvelope proteinSLE patient bloodInnate immune activationImmune complex formationActivate neutrophilsInterferon statusAutoantibody levelsIgG levelsHigher interferonImmune activationNeutrophil phagocytosisSLE IgGNeutrophil activationExtracellular trapsSLE plasmaNeutrophil elastasePatient's bloodErythematosusNeutrophilsPhagocytosis
2018
ERVmap analysis reveals genome-wide transcription of human endogenous retroviruses
Tokuyama M, Kong Y, Song E, Jayewickreme T, Kang I, Iwasaki A. ERVmap analysis reveals genome-wide transcription of human endogenous retroviruses. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: 12565-12572. PMID: 30455304, PMCID: PMC6294949, DOI: 10.1073/pnas.1814589115.Peer-Reviewed Original ResearchConceptsEndogenous retrovirusesGenome-wide identificationProtein-coding sequencesLocus-specific expressionWide transcriptionHuman genomeHuman endogenous retrovirusesERV lociExpression patternsRetroviral elementsPrimary cellsPeripheral blood mononuclear cellsRange of diseasesBreast cancer tissue samplesHuman healthSystemic lupus erythematosusBlood mononuclear cellsCancer tissue samplesDisease-associated antigensCell linesRNALack of toolsWeb toolLupus erythematosusPerforin expression