2021
B cells join T cell clusters in the host response to recurrent herpes simplex virus 2 infection
Gehlhausen JR, Iwasaki A. B cells join T cell clusters in the host response to recurrent herpes simplex virus 2 infection. Journal Of Clinical Investigation 2021, 131: e148300. PMID: 33938452, PMCID: PMC8087191, DOI: 10.1172/jci148300.Peer-Reviewed Original ResearchConceptsAntibody-secreting cellsB cellsRecurrent lesionsHerpes simplex virus 2 infectionHSV-2-specific antibodiesRecurrent genital herpes lesionsSimplex virus 2 infectionGenital herpes lesionsHSV-2 lesionsVirus 2 infectionT cell clustersSkin biopsy specimensB cell subsetsB cell populationsNaive B cellsStage of infectionLesion reactivationDisease resolutionImmune infiltratesAntibody levelsHerpes lesionsCell subsetsBiopsy specimensHost responseLesions
2019
Successful application of prime and pull strategy for a therapeutic HSV vaccine
Bernstein DI, Cardin RD, Bravo FJ, Awasthi S, Lu P, Pullum DA, Dixon DA, Iwasaki A, Friedman HM. Successful application of prime and pull strategy for a therapeutic HSV vaccine. Npj Vaccines 2019, 4: 33. PMID: 31396405, PMCID: PMC6671986, DOI: 10.1038/s41541-019-0129-1.Peer-Reviewed Original ResearchHerpes simplex virus type 2PBS control groupRecurrent sheddingControl groupVaginal HSV-2 infectionSimplex virus type 2Herpes simplex virus vaccineRecurrent HSV diseaseTherapeutic HSV vaccinesHSV-2 infectionCombinations of vaccinesGuinea pig modelVirus type 2Imiquimod groupHSV diseaseHSV vaccineRecurrent diseaseRecurrent lesionsRecurrent HSVVaccinated groupGlycoprotein vaccineTrivalent vaccineImmune cellsVirus vaccineGenital tract