2016
Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality
Khoury-Hanold W, Yordy B, Kong P, Kong Y, Ge W, Szigeti-Buck K, Ralevski A, Horvath TL, Iwasaki A. Viral Spread to Enteric Neurons Links Genital HSV-1 Infection to Toxic Megacolon and Lethality. Cell Host & Microbe 2016, 19: 788-799. PMID: 27281569, PMCID: PMC4902295, DOI: 10.1016/j.chom.2016.05.008.Peer-Reviewed Original ResearchConceptsGenital HSV-1 infectionEnteric nervous systemHSV-1 infectionSensory nervous systemNervous systemGenital herpesToxic megacolonHSV-1Genital mucosal epithelial cellsPeripheral sensory nervous systemDorsal root gangliaPathological inflammatory responsesMucosal epithelial cellsHerpes simplex virus 1Simplex virus 1Urinary retentionEnteric neuronsLaxative treatmentAutonomic gangliaRoot gangliaInflammatory responseViral gene transcriptionMouse modelInfectionEpithelial cells
2012
A Neuron-Specific Role for Autophagy in Antiviral Defense against Herpes Simplex Virus
Yordy B, Iijima N, Huttner A, Leib D, Iwasaki A. A Neuron-Specific Role for Autophagy in Antiviral Defense against Herpes Simplex Virus. Cell Host & Microbe 2012, 12: 334-345. PMID: 22980330, PMCID: PMC3454454, DOI: 10.1016/j.chom.2012.07.013.Peer-Reviewed Original ResearchConceptsI interferonHSV-1 replicationDorsal root ganglionic neuronsType I IFN treatmentHerpes simplex type 1I IFN treatmentI IFNsHSV-1 infectionHerpes simplex virusNeuron-specific rolesSimplex type 1Type I interferonMucosal epithelial cellsDRG neuronsGanglionic neuronsNeurotropic virusesIFN treatmentSimplex virusViral infectionAntiviral pathwaysViral replicationType 1Antiviral strategiesLittle type INeurons