Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection
McPadden J, Warner F, Young HP, Hurley NC, Pulk RA, Singh A, Durant TJS, Gong G, Desai N, Haimovich A, Taylor RA, Gunel M, Dela Cruz CS, Farhadian SF, Siner J, Villanueva M, Churchwell K, Hsiao A, Torre CJ, Velazquez EJ, Herbst RS, Iwasaki A, Ko AI, Mortazavi BJ, Krumholz HM, Schulz WL. Clinical characteristics and outcomes for 7,995 patients with SARS-CoV-2 infection. PLOS ONE 2021, 16: e0243291. PMID: 33788846, PMCID: PMC8011821, DOI: 10.1371/journal.pone.0243291.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionYale New Haven HealthSARS-CoV-2Hospital mortalityRisk of admissionMale sexRisk factorsSARS-CoV-2 testingInvasive mechanical ventilationSevere acute respiratory syndrome virusBurden of diseaseRT-PCR testingAcademic health systemDiverse patient populationsRespiratory syndrome virusEthnic groupsAdult patientsClinical characteristicsDischarge dispositionRespiratory supportPrimary outcomeTreatment guidelinesMechanical ventilationRetrospective studyPatient populationSex differences in immune responses
Takahashi T, Iwasaki A. Sex differences in immune responses. Science 2021, 371: 347-348. PMID: 33479140, DOI: 10.1126/science.abe7199.Peer-Reviewed Original ResearchConceptsImmune responseCOVID-19Sex differencesSevere COVID-19Risk of deathHigher mortality riskCOVID-19 mortalityPossible biological mechanismsCOVID-19 incidenceMale sexRisk factorsSevere diseaseHigh riskMortality riskMale sex biasOld maleSex-disaggregated dataBehavioral factorsBiological sex differencesDeathVulnerable groupsRiskBiological mechanismsMalesSex