2008
Epithelial dendritic cells in vagina rapidly renew from bone marrow precursors
Iijima N, Linehan M, Saeland S, Iwasaki A. Epithelial dendritic cells in vagina rapidly renew from bone marrow precursors. The FASEB Journal 2008, 22: 851.7-851.7. DOI: 10.1096/fasebj.22.1_supplement.851.7.Peer-Reviewed Original ResearchLangerhans cellsHerpes simplex virus 2Epithelial dendritic cellsSkin Langerhans cellsPrimary immune responseEpidermal Langerhans cellsSimplex virus 2Mucosal epithelial liningBone marrow precursorsSquamous epithelial layerDendritic cellsProfessional APCsStratified squamous epithelial layerSex hormonesImmune responseOral cavityVaginal mucosaBone marrowEpithelial liningGr-1Marrow precursorsActivation statusSpecialized subsetCytometric analysisCD11b
2003
Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A. Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells. Journal Of Experimental Medicine 2003, 198: 513-520. PMID: 12900525, PMCID: PMC2194085, DOI: 10.1084/jem.20030162.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationBone Marrow CellsCpG IslandsDendritic CellsDNA-Binding ProteinsEndosomesFemaleHerpesvirus 2, HumanHumansInterferon-alphaMaleMiceMice, Inbred StrainsMice, KnockoutMyeloid Differentiation Factor 88Receptors, Cell SurfaceReceptors, ImmunologicSignal TransductionToll-Like Receptor 9ConceptsHerpes simplex virus 2Plasmacytoid dendritic cellsIFN-alpha secretionToll-like receptorsSimplex virus 2Dendritic cellsIFN-alphaI interferonToll-like receptor 9Virus 2Adaptor molecule MyD88Type I interferonHSV-2 DNADose-dependent mannerMouse bone marrowMolecule MyD88Receptor 9Knockout miceBone marrowTLR9Potent secretorsSecretionOligonucleotide treatmentVirus recognitionBafilomycin A1