2023
SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)
Proal A, VanElzakker M, Aleman S, Bach K, Boribong B, Buggert M, Cherry S, Chertow D, Davies H, Dupont C, Deeks S, Eimer W, Ely E, Fasano A, Freire M, Geng L, Griffin D, Henrich T, Iwasaki A, Izquierdo-Garcia D, Locci M, Mehandru S, Painter M, Peluso M, Pretorius E, Price D, Putrino D, Scheuermann R, Tan G, Tanzi R, VanBrocklin H, Yonker L, Wherry E. SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC). Nature Immunology 2023, 24: 1616-1627. PMID: 37667052, DOI: 10.1038/s41590-023-01601-2.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 reservoirPost-acute sequelaeImmune responseHost immune responseCoronavirus SARS-CoV-2COVID-19SARS-CoV-2Neuroimmune abnormalitiesAcute infectionLong COVIDClinical trialsViral RNAMillions of peopleSequelaeFurther studiesViral proteinsPathologyResearch prioritiesRNA/proteinBiological factorsPASCAntiviralsInfectionAbnormalitiesTrials
2022
Unexplained post-acute infection syndromes
Choutka J, Jansari V, Hornig M, Iwasaki A. Unexplained post-acute infection syndromes. Nature Medicine 2022, 28: 911-923. PMID: 35585196, DOI: 10.1038/s41591-022-01810-6.Peer-Reviewed Original ResearchConceptsPost-acute sequelaeMyalgic encephalomyelitis/chronic fatigue syndromeSARS-CoV-2 infectionCertain acute infectionsMinority of patientsChronic fatigue syndromeSubstantial healthcare burdenSimilar symptom profilesSARS-CoV-2Common etiopathogenesisAcute infectionInfection syndromeClinical featuresFatigue syndromeChronic disabilityHealthcare burdenChronic illnessSymptom profilesInfectious agentsInfectionPotential involvementSequelaeSyndromeField of medicinePatients
2021
Impact of Chronic HIV Infection on SARS-CoV-2 Infection, COVID-19 Disease and Vaccines
Yang Y, Iwasaki A. Impact of Chronic HIV Infection on SARS-CoV-2 Infection, COVID-19 Disease and Vaccines. Current HIV/AIDS Reports 2021, 19: 5-16. PMID: 34843064, PMCID: PMC8628277, DOI: 10.1007/s11904-021-00590-x.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionSARS-CoV-2Human immune deficiency virus (HIV) infectionSARS-CoV-2 acute infectionImmune systemSevere acute respiratory syndrome coronavirus 2Severe SARS-CoV-2Acute respiratory syndrome coronavirus 2Respiratory syndrome coronavirus 2Chronic HIV infectionSyndrome coronavirus 2Effectiveness of vaccinesHost immune systemCOVID-19 diseaseRecent FindingsPeopleAntiretroviral therapyImmunological changesAcute infectionHIV infectionDisease complicationsPersistent inflammationCoronavirus 2Functional impairmentVirus infectionImmune response
2011
CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input
Kumamoto Y, Mattei LM, Sellers S, Payne GW, Iwasaki A. CD4+ T cells support cytotoxic T lymphocyte priming by controlling lymph node input. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 8749-8754. PMID: 21555577, PMCID: PMC3102372, DOI: 10.1073/pnas.1100567108.Peer-Reviewed Original ResearchConceptsT cellsDendritic cellsCytotoxic T-lymphocyte primingT lymphocyte responsesAntigen-specific CTLsT lymphocyte primingSecondary lymphoid organsT cell helpCD40-dependent mannerNaïve B cellsCognate CTLsAcute infectionLymph nodesLymphocyte primingLymphocyte responsesLymphocyte recruitmentCTL expansionLymphoid organsImmune responseNaïve precursorsB cellsImmune systemReactive LNsIntracellular pathogensInfection