2003
Cellular and Network Mechanisms of Slow Oscillatory Activity (<1 Hz) and Wave Propagations in a Cortical Network Model
Compte A, Sanchez-Vives M, McCormick D, Wang X. Cellular and Network Mechanisms of Slow Oscillatory Activity (<1 Hz) and Wave Propagations in a Cortical Network Model. Journal Of Neurophysiology 2003, 89: 2707-2725. PMID: 12612051, DOI: 10.1152/jn.00845.2002.Peer-Reviewed Original ResearchConceptsSlow oscillatory activityOscillatory activityUp statesSpontaneous spike dischargeMinority of neuronsSlow-wave sleepStrong recurrent excitationSpike dischargesTonic firingCerebrospinal fluidDown statePharmacological manipulationRecurrent excitationCortical network modelSlow adaptation currentBiophysical network modelInput resistancePhysiological effectsSlow oscillationsPatchy connectionsInhibition blocksVivo dataNeuronsSingle neuron behaviorBath solution
1999
Ca2+‐Mediated Up‐Regulation of Ih in the Thalamus: How Cell‐Intrinsic Ionic Currents May Shape Network Activity
LÜTHI A, McCORMICK D. Ca2+‐Mediated Up‐Regulation of Ih in the Thalamus: How Cell‐Intrinsic Ionic Currents May Shape Network Activity. Annals Of The New York Academy Of Sciences 1999, 868: 765-769. PMID: 10414362, DOI: 10.1111/j.1749-6632.1999.tb11354.x.Peer-Reviewed Original Research
1998
Periodicity of Thalamic Spindle Waves Is Abolished by ZD7288,a Blocker of I h
Lüthi A, Bal T, McCormick D. Periodicity of Thalamic Spindle Waves Is Abolished by ZD7288,a Blocker of I h. Journal Of Neurophysiology 1998, 79: 3284-3289. PMID: 9636128, DOI: 10.1152/jn.1998.79.6.3284.Peer-Reviewed Original ResearchConceptsSpindle wavesHyperpolarization-activated cation current IhCurrent-clamp recordingsIntracellular recording techniquesBlock of IhVoltage-clamp recordingsRebound burstsThalamic activityRefractory periodPacemaker currentLocal applicationZD7288AfterdepolarizationsCurrent IhRecording techniquesRepetitive hyperpolarizationNetwork activityHyperpolarizationSlow rhythmicityFurther supportIH
1996
Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices
Destexhe A, Bal T, McCormick D, Sejnowski T. Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices. Journal Of Neurophysiology 1996, 76: 2049-2070. PMID: 8890314, DOI: 10.1152/jn.1996.76.3.2049.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBicucullineCalciumCalcium ChannelsElectrophysiologyFerretsGABA AntagonistsIn Vitro TechniquesIon ChannelsKineticsMembrane PotentialsModels, NeurologicalNeural Networks, ComputerPotassium ChannelsRecruitment, NeurophysiologicalRefractory Period, ElectrophysiologicalReticular FormationSynapsesThalamusUp-RegulationConceptsInhibitory postsynaptic potentialsExcitatory postsynaptic potentialsSlow inhibitory postsynaptic potentialFerret thalamic slicesActivity-dependent upregulationTC cellsRE cellsPostsynaptic potentialsThalamic slicesGABAergic inhibitory postsynaptic potentialsSpindle oscillationsCalcium-sensitive currentGABAB inhibitory postsynaptic potentialsLocal axonal arborizationsThalamic reticular neuronsGamma-aminobutyric acidRE neuronsGABAB receptorsIsoxazolepropionic acidRebound burstsReticular neuronsTC neuronsGABAA inhibitionAxonal arborizationBurst discharges
1992
Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons
Huguenard J, McCormick D. Simulation of the currents involved in rhythmic oscillations in thalamic relay neurons. Journal Of Neurophysiology 1992, 68: 1373-1383. PMID: 1279135, DOI: 10.1152/jn.1992.68.4.1373.Peer-Reviewed Original Research
1989
Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current
Pape H, McCormick D. Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current. Nature 1989, 340: 715-718. PMID: 2475782, DOI: 10.1038/340715a0.Peer-Reviewed Original ResearchConceptsThalamic neuronsRhythmic burstsAction potentialsHyperpolarization-activated cation currentSingle spike activityGenerate action potentialsSlow-wave sleepSingle-spike firingState of excitabilityAction potential generationSerotonergic inputNeurons displaySynaptic processingSpike activityCation currentThalamic burstsSpike firingNoradrenalineSerotoninCellular mechanismsNeuronsRhythmic oscillationsNovel actionBehavioral statesCyclic AMP
1986
Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance
McCormick D, Prince D. Acetylcholine induces burst firing in thalamic reticular neurones by activating a potassium conductance. Nature 1986, 319: 402-405. PMID: 2418361, DOI: 10.1038/319402a0.Peer-Reviewed Original ResearchConceptsNeuronal activityCholinergic inhibitory mechanismSingle spike activityRole of acetylcholineApplication of acetylcholineCentral nervous systemIntrinsic membrane propertiesAcetylcholine inducesM2 subclassCholinergic actionCholinergic inhibitionCholinergic inputMuscarinic receptorsBurst dischargesExcitatory modulatorThalamic neuronesNervous systemSpike activityFiring patternsPotassium conductanceReticular neuronesAcetylcholineNeuronesReticular systemInhibitory mechanism