2007
Lack of Orientation and Direction Selectivity in a Subgroup of Fast-Spiking Inhibitory Interneurons: Cellular and Synaptic Mechanisms and Comparison with Other Electrophysiological Cell Types
Nowak L, Sanchez-Vives M, McCormick D. Lack of Orientation and Direction Selectivity in a Subgroup of Fast-Spiking Inhibitory Interneurons: Cellular and Synaptic Mechanisms and Comparison with Other Electrophysiological Cell Types. Cerebral Cortex 2007, 18: 1058-1078. PMID: 17720684, PMCID: PMC3136126, DOI: 10.1093/cercor/bhm137.Peer-Reviewed Original Research
2003
Electrophysiological Classes of Cat Primary Visual Cortical Neurons In Vivo as Revealed by Quantitative Analyses
Nowak L, Azouz R, Sanchez-Vives M, Gray C, McCormick D. Electrophysiological Classes of Cat Primary Visual Cortical Neurons In Vivo as Revealed by Quantitative Analyses. Journal Of Neurophysiology 2003, 89: 1541-1566. PMID: 12626627, DOI: 10.1152/jn.00580.2002.Peer-Reviewed Original ResearchConceptsAction potentialsElectrophysiological classesCortical neuronsIntrinsic burstingPrimary visual cortical neuronsShort-duration action potentialsCortical neuronal functionSpiny stellate cellsRegular spikingSpiny stellate neuronsVisual cortical neuronsFrequency adaptationCat area 17High-frequency burstsSpike frequency adaptationCH neuronsTonic trainsNonpyramidal cellsIB neuronsRS neuronsStellate neuronsPyramidal cellsArea 17FS neuronsStellate cellsCellular and Network Mechanisms of Slow Oscillatory Activity (<1 Hz) and Wave Propagations in a Cortical Network Model
Compte A, Sanchez-Vives M, McCormick D, Wang X. Cellular and Network Mechanisms of Slow Oscillatory Activity (<1 Hz) and Wave Propagations in a Cortical Network Model. Journal Of Neurophysiology 2003, 89: 2707-2725. PMID: 12612051, DOI: 10.1152/jn.00845.2002.Peer-Reviewed Original ResearchConceptsSlow oscillatory activityOscillatory activityUp statesSpontaneous spike dischargeMinority of neuronsSlow-wave sleepStrong recurrent excitationSpike dischargesTonic firingCerebrospinal fluidDown statePharmacological manipulationRecurrent excitationCortical network modelSlow adaptation currentBiophysical network modelInput resistancePhysiological effectsSlow oscillationsPatchy connectionsInhibition blocksVivo dataNeuronsSingle neuron behaviorBath solution
2002
Neuromodulatory Role of Serotonin in the Ferret Thalamus
Monckton J, McCormick D. Neuromodulatory Role of Serotonin in the Ferret Thalamus. Journal Of Neurophysiology 2002, 87: 2124-2136. PMID: 11929930, DOI: 10.1152/jn.00650.2001.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsAction of serotoninDorsal thalamusLocal interneuronsSpontaneous inhibitory postsynaptic potentialsDorsal lateral geniculate nucleusGABAergic synaptic transmissionPrimary sensory nucleiIntracellular recording techniquesPresence of tetrodotoxinTonic firing modesLateral geniculate nucleusModulation of neuronsExtracellular potassium concentrationSleep-wake cycleReversal potential shiftsSerotonergic fibersThalamocortical neuronsAssociative nucleiMedial geniculateNeuromodulatory rolePostsynaptic potentialsSerotonergic inputLateral posteriorSlice preparation
2000
Cellular and network mechanisms of rhythmic recurrent activity in neocortex
Sanchez-Vives M, McCormick D. Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nature Neuroscience 2000, 3: 1027-1034. PMID: 11017176, DOI: 10.1038/79848.Peer-Reviewed Original ResearchConceptsSlow-wave sleepLocal cortical circuitsSlow oscillationsFerret neocortexCerebral cortexExtracellular ionic compositionPyramidal neuronsCortical circuitsCortical rhythmsSlow rhythmRecurrent excitationLayer 5NeocortexInhibitory networksExcitatory interactionsBathing mediumExcitatory stateSleepRecurrent activityRhythmCortexNeuronsNetwork mechanismsMembrane Mechanisms Underlying Contrast Adaptation in Cat Area 17In Vivo
Sanchez-Vives M, Nowak L, McCormick D. Membrane Mechanisms Underlying Contrast Adaptation in Cat Area 17In Vivo. Journal Of Neuroscience 2000, 20: 4267-4285. PMID: 10818163, PMCID: PMC6772627, DOI: 10.1523/jneurosci.20-11-04267.2000.Peer-Reviewed Original ResearchConceptsPrimary visual cortexContrast adaptationDorsal lateral geniculate nucleus (dLGN) neuronsVisual cortexLateral geniculate nucleus neuronsCat primary visual cortexAction potential activityHigh-contrast visual stimulusIntrinsic neuronal mechanismsMembrane potentialApparent membrane conductanceVisual cortex cellsVisual stimuliLow-contrast stimuliNeuronal responsivenessDLGN cellsNucleus neuronsCortical neuronsIntracellular recordingsIntracellular injectionNeuronal activityReduced responsivenessSynaptic barragesNeuronal mechanismsFiring rate
1999
Are thalamocortical rhythms the rosetta stone of a subset of neurological disorders?
McCormick D. Are thalamocortical rhythms the rosetta stone of a subset of neurological disorders? Nature Medicine 1999, 5: 1349-1351. PMID: 10581069, DOI: 10.1038/70911.Peer-Reviewed Original ResearchMeSH KeywordsCerebral CortexElectrophysiologyHumansModels, NeurologicalNervous System DiseasesPeriodicityThalamus
1998
The Functional Influence of Burst and Tonic Firing Mode on Synaptic Interactions in the Thalamus
Kim U, McCormick D. The Functional Influence of Burst and Tonic Firing Mode on Synaptic Interactions in the Thalamus. Journal Of Neuroscience 1998, 18: 9500-9516. PMID: 9801387, PMCID: PMC6792899, DOI: 10.1523/jneurosci.18-22-09500.1998.Peer-Reviewed Original ResearchConceptsAction potentialsThalamocortical neuronsPostsynaptic neuronsDorsal lateral geniculate nucleus (dLGN) neuronsLateral geniculate nucleus neuronsDual intracellular recordingsTonic firing modesLow-threshold Ca2Single action potentialHigh-frequency burstsAction potential generationPerigeniculate neuronsTonic trainsCell typesMembrane potentialNucleus neuronsBurst dischargesIntracellular recordingsGeneration of Ca2Synaptic transmissionPresynaptic cellTemporal summationEpileptic seizuresSynchronized rhythmic oscillationsSynaptic interactionsPeriodicity of Thalamic Spindle Waves Is Abolished by ZD7288,a Blocker of I h
Lüthi A, Bal T, McCormick D. Periodicity of Thalamic Spindle Waves Is Abolished by ZD7288,a Blocker of I h. Journal Of Neurophysiology 1998, 79: 3284-3289. PMID: 9636128, DOI: 10.1152/jn.1998.79.6.3284.Peer-Reviewed Original ResearchConceptsSpindle wavesHyperpolarization-activated cation current IhCurrent-clamp recordingsIntracellular recording techniquesBlock of IhVoltage-clamp recordingsRebound burstsThalamic activityRefractory periodPacemaker currentLocal applicationZD7288AfterdepolarizationsCurrent IhRecording techniquesRepetitive hyperpolarizationNetwork activityHyperpolarizationSlow rhythmicityFurther supportIH
1997
Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical Neurons In Vitro
Sanchez-Vives M, McCormick D. Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical Neurons In Vitro. Journal Of Neuroscience 1997, 17: 8880-8893. PMID: 9348355, PMCID: PMC6573089, DOI: 10.1523/jneurosci.17-22-08880.1997.Peer-Reviewed Original ResearchMeSH KeywordsAcetazolamideAnimalsAnticonvulsantsBaclofenBicucullineCerebral CortexConvulsantsElectrophysiologyFemaleFerretsGABA AgonistsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesMaleMembrane PotentialsNeural InhibitionNeural PathwaysNeuronsOrganophosphorus CompoundsPicrotoxinReceptors, GABA-AReceptors, GABA-BReceptors, PresynapticThalamic NucleiConceptsGABAB receptorsThalamocortical neuronsPGN neuronsGABAA receptorsThalamocortical cellsGABAB receptor-mediated IPSPsLocal applicationDorsal lateral geniculate nucleusReceptor-mediated IPSPsSynchronous slow oscillationsLow-intensity stimulationLow-threshold Ca2Lateral geniculate nucleusStrong activationPerigeniculate nucleusGeniculate nucleusIntracellular recordingsInhibitory influenceAction potentialsIntensity stimulationThreshold Ca2IPSPsNeuronsSpindle wavesPathological conditionsInfluence of low and high frequency inputs on spike timing in visual cortical neurons.
Nowak L, Sanchez-Vives M, McCormick D. Influence of low and high frequency inputs on spike timing in visual cortical neurons. Cerebral Cortex 1997, 7: 487-501. PMID: 9276174, DOI: 10.1093/cercor/7.6.487.Peer-Reviewed Original ResearchConceptsCortical neuronsAction potentialsFerret visual cortexAction potential dischargeVisual cortical neuronsInterspike intervalsAction potential generationAction potential timingTemporal precisionPostsynaptic potentialsGamma frequency rangeIntracellular recordingsIntracellular injectionVisual cortexPotential dischargeNeuronsVisual stimulationCortical networksRegular spikingSensory stimuliSingle trialHigh temporal precisionPotential timingHigh frequencyPotential generationModulation of spindle oscillations by acetylcholine, cholecystokinin and 1S,3R-ACPD in the ferret lateral geniculate and perigeniculate nuclei in vitro
Lee K, McCormick D. Modulation of spindle oscillations by acetylcholine, cholecystokinin and 1S,3R-ACPD in the ferret lateral geniculate and perigeniculate nuclei in vitro. Neuroscience 1997, 77: 335-350. PMID: 9472394, DOI: 10.1016/s0306-4522(96)00481-2.Peer-Reviewed Original ResearchConceptsSpindle wave generationInhibitory postsynaptic potentialsThalamocortical neuronsLocal applicationTonic dischargeSpindle wavesPostsynaptic potentialsPerigeniculate nucleusGlutamate metabotropic receptor agonistMetabotropic receptor agonistMembrane depolarizationEffects of neurotransmittersSlow-wave sleepPerigeniculate neuronsLeak potassium currentGABAergic cellsGABAergic neuronsLateral geniculateReceptor agonistTonic activityWave sleepPotassium currentThalamic networkACPDNeurons
1996
Are the Interlaminar Zones of the Ferret Dorsal Lateral Geniculate Nucleus Actually Part of the Perigeniculate Nucleus?
Sanchez-Vives M, Bal T, Kim U, von Krosigk M, McCormick D. Are the Interlaminar Zones of the Ferret Dorsal Lateral Geniculate Nucleus Actually Part of the Perigeniculate Nucleus? Journal Of Neuroscience 1996, 16: 5923-5941. PMID: 8815875, PMCID: PMC6579195, DOI: 10.1523/jneurosci.16-19-05923.1996.Peer-Reviewed Original ResearchConceptsInterlaminar zonesThalamocortical cellsDorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusFerret LGNdLow-threshold Ca2Calbindin-positive cellsLateral geniculate nucleusCalbindin stainingPerigeniculate neuronsPGN cellsContralateral eyeA-laminaeAxon collateralsC laminaePGN neuronsPerigeniculate nucleusGeniculate nucleusIntracellular injectionLamina AElectrophysiological propertiesLocal applicationProlonged depolarizationProlonged hyperpolarizationNeuronsIonic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices
Destexhe A, Bal T, McCormick D, Sejnowski T. Ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices. Journal Of Neurophysiology 1996, 76: 2049-2070. PMID: 8890314, DOI: 10.1152/jn.1996.76.3.2049.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBicucullineCalciumCalcium ChannelsElectrophysiologyFerretsGABA AntagonistsIn Vitro TechniquesIon ChannelsKineticsMembrane PotentialsModels, NeurologicalNeural Networks, ComputerPotassium ChannelsRecruitment, NeurophysiologicalRefractory Period, ElectrophysiologicalReticular FormationSynapsesThalamusUp-RegulationConceptsInhibitory postsynaptic potentialsExcitatory postsynaptic potentialsSlow inhibitory postsynaptic potentialFerret thalamic slicesActivity-dependent upregulationTC cellsRE cellsPostsynaptic potentialsThalamic slicesGABAergic inhibitory postsynaptic potentialsSpindle oscillationsCalcium-sensitive currentGABAB inhibitory postsynaptic potentialsLocal axonal arborizationsThalamic reticular neuronsGamma-aminobutyric acidRE neuronsGABAB receptorsIsoxazolepropionic acidRebound burstsReticular neuronsTC neuronsGABAA inhibitionAxonal arborizationBurst dischargesAbolition of Spindle Oscillations by Serotonin and Norepinephrine in the Ferret Lateral Geniculate and Perigeniculate Nuclei In Vitro
Lee K, McCormick D. Abolition of Spindle Oscillations by Serotonin and Norepinephrine in the Ferret Lateral Geniculate and Perigeniculate Nuclei In Vitro. Neuron 1996, 17: 309-321. PMID: 8780654, DOI: 10.1016/s0896-6273(00)80162-2.Peer-Reviewed Original ResearchConceptsSpindle wave generationThalamocortical neuronsSpindle wavesPerigeniculate nucleusLocal applicationDorsal lateral geniculate nucleusHyperpolarization-activated cation current IhModulation of IhLateral geniculate nucleusBeta-adrenergic agonistsAdenylyl cyclase activatorGABAergic cellsLateral geniculateChannel blockersGeniculate nucleusNorepinephrineLamina A1Current IhNeuronsSpindle oscillationsCyclase activatorSerotoninIHBlockersAgonistsWhat Stops Synchronized Thalamocortical Oscillations?
Bal T, McCormick D. What Stops Synchronized Thalamocortical Oscillations? Neuron 1996, 17: 297-308. PMID: 8780653, DOI: 10.1016/s0896-6273(00)80161-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexCesiumElectrophysiologyFemaleFerretsMaleMembrane PotentialsPeriodicityThalamus
1995
Electrophysiological and pharmacological properties of interneurons in the cat dorsal lateral geniculate nucleus
Pape H, McCormick D. Electrophysiological and pharmacological properties of interneurons in the cat dorsal lateral geniculate nucleus. Neuroscience 1995, 68: 1105-1125. PMID: 8544986, DOI: 10.1016/0306-4522(95)00205-w.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCatsElectric StimulationElectrophysiologyExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsGABA-A Receptor AgonistsGABA-A Receptor AntagonistsGABA-B Receptor AgonistsGABA-B Receptor AntagonistsGamma-Aminobutyric AcidGeniculate BodiesIn Vitro TechniquesInterneuronsPatch-Clamp TechniquesThalamusConceptsDorsal lateral geniculate nucleusCat dorsal lateral geniculate nucleusLateral geniculate nucleusAction potentialsGeniculate nucleusGABAB receptor agonist baclofenGABAA receptor agonist muscimolSpontaneous action potential activityPharmacological propertiesStrong spike frequency adaptationSmall slow depolarizationSubpopulation of interneuronsReceptor agonist baclofenSpontaneous spike activityAction potential dischargeDorsal lateral geniculateReceptor agonist muscimolApplication of serotoninAction potential activityApplication of acetylcholineChloride equilibrium potentialHigh-frequency trainsSpike frequency adaptationUnique electrophysiological characteristicsAgonist baclofenSpindle waves are propagating synchronized oscillations in the ferret LGNd in vitro
Kim U, Bal T, McCormick D. Spindle waves are propagating synchronized oscillations in the ferret LGNd in vitro. Journal Of Neurophysiology 1995, 74: 1301-1323. PMID: 7500152, DOI: 10.1152/jn.1995.74.3.1301.Peer-Reviewed Original ResearchPostnatal development of synchronized network oscillations in the ferret dorsal lateral geniculate and perigeniculate nuclei
McCormick D, Trent F, Ramoa A. Postnatal development of synchronized network oscillations in the ferret dorsal lateral geniculate and perigeniculate nuclei. Journal Of Neuroscience 1995, 15: 5739-5752. PMID: 7643215, PMCID: PMC6577643, DOI: 10.1523/jneurosci.15-08-05739.1995.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, NewbornBicucullineElectrophysiologyFemaleFerretsGABA AntagonistsGeniculate BodiesMaleNerve NetOscillometrySeizuresConceptsInhibitory postsynaptic potentialsLow-threshold Ca2PGN neuronsIntracellular recordingsAction potentialsSpindle wavesPostnatal developmentGABAA receptorsRelay cellsElectrophysiological propertiesGABAA antagonist bicuculline methiodideHigh-frequency burst dischargesThreshold Ca2Dorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusSpindle wave generationNetwork oscillationsDorsal lateral geniculateAction potential firingLateral geniculate nucleusThalamocortical relay cellsSynchronized network oscillationsBarrages of EPSPsLGNd relay cellsHigh-frequency burstsRole of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro.
Bal T, von Krosigk M, McCormick D. Role of the ferret perigeniculate nucleus in the generation of synchronized oscillations in vitro. The Journal Of Physiology 1995, 483: 665-685. PMID: 7776250, PMCID: PMC1157809, DOI: 10.1113/jphysiol.1995.sp020613.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBicucullineElectrophysiologyFerretsGABA-A Receptor AntagonistsGeniculate BodiesNeuronsOscillometryReaction TimeConceptsExcitatory postsynaptic potentialsInhibitory postsynaptic potentialsPGN cellsSpindle wave generationLow-threshold Ca2Perigeniculate nucleusSpindle wavesPGN neuronsPostsynaptic potentialsRelay neuronsGABAA receptorsRelay cellsHigh-frequency burst dischargesThreshold Ca2Dorsal lateral geniculate nucleusNon-NMDA receptorsShort-duration inhibitory postsynaptic potentialMarked increaseLateral geniculate nucleusExtracellular recording techniquesVitro. 2GABAergic neuronsGABAergic receptorsGABAB receptorsProgressive hyperpolarization