2012
Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation
Tahvildari B, Wölfel M, Duque A, McCormick DA. Selective Functional Interactions between Excitatory and Inhibitory Cortical Neurons and Differential Contribution to Persistent Activity of the Slow Oscillation. Journal Of Neuroscience 2012, 32: 12165-12179. PMID: 22933799, PMCID: PMC3466092, DOI: 10.1523/jneurosci.1181-12.2012.Peer-Reviewed Original ResearchConceptsInhibitory synaptic potentialsSynaptic potentialsEntorhinal cortexSlow oscillationsCortical neuronal subtypesInhibitory synaptic eventsMouse entorhinal cortexSomatostatin-containing interneuronsVasoactive intestinal peptideInhibitory cortical neuronsAction potential activityCortical pyramidal cellsWhole-cell recordingsRecurrent network activitySubmerged slice preparationPersistent activityExcitatory pyramidalDifferent excitatoryPyramidal neuronsIntestinal peptideNeuropeptide YCortical neuronsPyramidal cellsSlice preparationExcitatory neurons
2007
State Changes Rapidly Modulate Cortical Neuronal Responsiveness
Hasenstaub A, Sachdev RN, McCormick DA. State Changes Rapidly Modulate Cortical Neuronal Responsiveness. Journal Of Neuroscience 2007, 27: 9607-9622. PMID: 17804621, PMCID: PMC6672966, DOI: 10.1523/jneurosci.2184-07.2007.Peer-Reviewed Original ResearchConceptsNeuronal responsivenessWhisker stimulationWhisker stimuliCircuit activityCortical neuronal responsivenessLocal circuit activityNetwork activityAction potential responsesLocal network activityRodent somatosensory cortexPostsynaptic potentialsSomatosensory cortexCortical neuronsIntracellular injectionWhisker deflectionCortical stateWhisker movementsPotential responsivenessAbility of stimuliSensory stimuliInhibitory mechanismStimulationResponsivenessSpontaneous alterationUp statesThalamic synchrony and dynamic regulation of global forebrain oscillations
Huguenard J, McCormick D. Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends In Neurosciences 2007, 30: 350-356. PMID: 17544519, DOI: 10.1016/j.tins.2007.05.007.Peer-Reviewed Original ResearchConceptsSpike-wave dischargesRelay neuronsReticular nucleusInhibitory thalamic reticular neuronsThalamic oscillatory activityGeneralized absence epilepsyThalamic reticular neuronsThalamocortical relay neuronsRegulation of excitabilityPost-inhibitory rebound mechanismAnnual INMED/TINS symposiumINMED/TINS special issue PhysiogenicThalamic synchronyReticular neuronsAbsence epilepsySynaptic connectivityThalamic circuitsThalamocortical networkSpindle generationThalamic networkPathological oscillationsOscillatory activitySpecific interventionsSleep spindlesGenetic alterations
2006
Neocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition
Haider B, Duque A, Hasenstaub A, McCormick D. Neocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition. Journal Of Neuroscience 2006, 26: 4535-4545. PMID: 16641233, PMCID: PMC6674060, DOI: 10.1523/jneurosci.5297-05.2006.Peer-Reviewed Original ResearchConceptsCerebral cortexNeocortical network activityReversal potentialUp statesPersistent network activityNetwork activityDepolarized reversal potentialSpontaneous network activityField potential recordingsLocal cortical circuitsLocal field potential recordingsNeuronal responsivenessCortical functionRecurrent excitatoryCortical circuitsSynaptic currentsPotential recordingsRecurrent excitationExcitatory conductancePrefrontal cortexInhibitory connectionsCortexStable network statesSlow oscillationsInhibition
2000
Cellular and network mechanisms of rhythmic recurrent activity in neocortex
Sanchez-Vives M, McCormick D. Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nature Neuroscience 2000, 3: 1027-1034. PMID: 11017176, DOI: 10.1038/79848.Peer-Reviewed Original ResearchConceptsSlow-wave sleepLocal cortical circuitsSlow oscillationsFerret neocortexCerebral cortexExtracellular ionic compositionPyramidal neuronsCortical circuitsCortical rhythmsSlow rhythmRecurrent excitationLayer 5NeocortexInhibitory networksExcitatory interactionsBathing mediumExcitatory stateSleepRecurrent activityRhythmCortexNeuronsNetwork mechanisms
1999
Modulation of a pacemaker current through Ca2+-induced stimulation of cAMP production
Lüthi A, McCormick D. Modulation of a pacemaker current through Ca2+-induced stimulation of cAMP production. Nature Neuroscience 1999, 2: 634-641. PMID: 10404196, DOI: 10.1038/10189.Peer-Reviewed Original ResearchConceptsHyperpolarization-activated cation currentIh activationThalamocortical rhythmsThalamocortical activityCation currentNeuronal propertiesPacemaker currentCAMP productionPersistent activationProlonged changesProlonged activationBrief increaseDependent modulationSlow recurrenceActivationSubsequent productionCa2RecurrenceModulationCa2+‐Mediated Up‐Regulation of Ih in the Thalamus: How Cell‐Intrinsic Ionic Currents May Shape Network Activity
LÜTHI A, McCORMICK D. Ca2+‐Mediated Up‐Regulation of Ih in the Thalamus: How Cell‐Intrinsic Ionic Currents May Shape Network Activity. Annals Of The New York Academy Of Sciences 1999, 868: 765-769. PMID: 10414362, DOI: 10.1111/j.1749-6632.1999.tb11354.x.Peer-Reviewed Original Research
1993
Mechanisms of oscillatory activity in guinea‐pig nucleus reticularis thalami in vitro: a mammalian pacemaker.
Bal T, McCormick D. Mechanisms of oscillatory activity in guinea‐pig nucleus reticularis thalami in vitro: a mammalian pacemaker. The Journal Of Physiology 1993, 468: 669-691. PMID: 8254530, PMCID: PMC1143849, DOI: 10.1113/jphysiol.1993.sp019794.Peer-Reviewed Original ResearchConceptsLow-threshold Ca2Nucleus reticularis thalamiRhythmic burst firingThreshold Ca2Reticularis thalamiBurst firingExtracellular Ca2Action potentialsOscillatory activityShort-latency burstsSingle spike activityVitro. 2Fast action potentialsNon-selective cationSlow ADPThalamic afferentsTonic dischargeNRT cellsIntracellular recordingsIntracellular injectionSpike AHPsSpike activitySingle neuronesExtracellular applicationReversal potential