2006
Neocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition
Haider B, Duque A, Hasenstaub A, McCormick D. Neocortical Network Activity In Vivo Is Generated through a Dynamic Balance of Excitation and Inhibition. Journal Of Neuroscience 2006, 26: 4535-4545. PMID: 16641233, PMCID: PMC6674060, DOI: 10.1523/jneurosci.5297-05.2006.Peer-Reviewed Original ResearchConceptsCerebral cortexNeocortical network activityReversal potentialUp statesPersistent network activityNetwork activityDepolarized reversal potentialSpontaneous network activityField potential recordingsLocal cortical circuitsLocal field potential recordingsNeuronal responsivenessCortical functionRecurrent excitatoryCortical circuitsSynaptic currentsPotential recordingsRecurrent excitationExcitatory conductancePrefrontal cortexInhibitory connectionsCortexStable network statesSlow oscillationsInhibition
2004
Histamine modulates thalamocortical activity by activating a chloride conductance in ferret perigeniculate neurons
Lee K, Broberger C, Kim U, McCormick D. Histamine modulates thalamocortical activity by activating a chloride conductance in ferret perigeniculate neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 6716-6721. PMID: 15096604, PMCID: PMC404111, DOI: 10.1073/pnas.0400817101.Peer-Reviewed Original ResearchConceptsApplication of histamineGamma-aminobutyric acidPerigeniculate nucleusGABAergic neuronsSingle spike activityMammalian central nervous systemCentral nervous systemHistaminergic actionPerigeniculate neuronsHistaminergic fibersHistaminergic systemHistaminergic receptorsTuberomammillary nucleusIontophoretic applicationPostsynaptic factorsThalamocortical activityInhibitory responsesNeuronal activityThalamic oscillationsNervous systemHistamineMembrane hyperpolarizationSpindle wavesIonotropic receptorsReversal potential
2000
Cellular Mechanisms of Long-Lasting Adaptation in Visual Cortical Neurons In Vitro
Sanchez-Vives M, Nowak L, McCormick D. Cellular Mechanisms of Long-Lasting Adaptation in Visual Cortical Neurons In Vitro. Journal Of Neuroscience 2000, 20: 4286-4299. PMID: 10818164, PMCID: PMC6772630, DOI: 10.1523/jneurosci.20-11-04286.2000.Peer-Reviewed Original ResearchConceptsSpike frequency adaptationSlow afterhyperpolarizationCortical neuronsFerret primary visual cortexProlonged dischargeCellular mechanismsVisual cortical neuronsPrimary visual cortexSlow spike frequency adaptationIntracellular recordingsIntracellular injectionRightward shiftAfterhyperpolarizationVisual cortexReversal potentialContrast adaptationNeuronsDischarge frequencyMembrane conductanceVivoVisual systemBlockadeCortexImportant role
1998
Functional and Ionic Properties of a Slow Afterhyperpolarization in Ferret Perigeniculate Neurons In Vitro
Kim U, Mccormick D. Functional and Ionic Properties of a Slow Afterhyperpolarization in Ferret Perigeniculate Neurons In Vitro. Journal Of Neurophysiology 1998, 80: 1222-1235. PMID: 9744934, DOI: 10.1152/jn.1998.80.3.1222.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnesthetics, LocalAnimalsApaminBicucullineCalciumCalcium Channel BlockersExcitatory Postsynaptic PotentialsFemaleFerretsGABA AntagonistsGamma-Aminobutyric AcidGeniculate BodiesLidocaineMaleNeuronsOmega-Conotoxin GVIAPeptidesPeriodicityPotassiumPotassium ChannelsSodiumTetraethylammoniumTetrodotoxinConceptsApplication of apaminSlow afterhyperpolarizationLow-threshold Ca2Perigeniculate neuronsPlateau potentialsBlock of Ca2Spindle wave generationMedium-duration afterhyperpolarizationGABAergic neuronsTonic dischargeFast afterhyperpolarizationPerigeniculate nucleusIntracellular recordingsAfterhyperpolarizationAction potentialsRefractory periodLocal applicationProlonged depolarizationRepetitive Ca2Spindle wavesReversal potentialNeuronsApaminMembrane conductanceActivation
1995
Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro.
Bal T, von Krosigk M, McCormick D. Synaptic and membrane mechanisms underlying synchronized oscillations in the ferret lateral geniculate nucleus in vitro. The Journal Of Physiology 1995, 483: 641-663. PMID: 7776249, PMCID: PMC1157808, DOI: 10.1113/jphysiol.1995.sp020612.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsLGNd relay cellsLateral geniculate nucleusPerigeniculate nucleusRelay cellsGABAB receptorsSpindle wavesPGN neuronsGeniculate nucleusBicuculline-sensitive inhibitory postsynaptic potentialsExcitatory amino acid transmissionDorsal lateral geniculate nucleusFerret dorsal lateral geniculate nucleusFerret lateral geniculate nucleusAmino acid transmissionReversal potentialIntracellular recording techniquesLow-threshold Ca2Vitro. 2Mean reversal potentialSingle-unit activityLocal electrical stimulationKCl-filled microelectrodesPharmacological antagonismBicuculline methiodide
1993
Mechanisms of oscillatory activity in guinea‐pig nucleus reticularis thalami in vitro: a mammalian pacemaker.
Bal T, McCormick D. Mechanisms of oscillatory activity in guinea‐pig nucleus reticularis thalami in vitro: a mammalian pacemaker. The Journal Of Physiology 1993, 468: 669-691. PMID: 8254530, PMCID: PMC1143849, DOI: 10.1113/jphysiol.1993.sp019794.Peer-Reviewed Original ResearchConceptsLow-threshold Ca2Nucleus reticularis thalamiRhythmic burst firingThreshold Ca2Reticularis thalamiBurst firingExtracellular Ca2Action potentialsOscillatory activityShort-latency burstsSingle spike activityVitro. 2Fast action potentialsNon-selective cationSlow ADPThalamic afferentsTonic dischargeNRT cellsIntracellular recordingsIntracellular injectionSpike AHPsSpike activitySingle neuronesExtracellular applicationReversal potential
1989
GABA as an inhibitory neurotransmitter in human cerebral cortex
McCormick D. GABA as an inhibitory neurotransmitter in human cerebral cortex. Journal Of Neurophysiology 1989, 62: 1018-1027. PMID: 2573696, DOI: 10.1152/jn.1989.62.5.1018.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsGamma-aminobutyric acidEarly inhibitory postsynaptic potentialHuman cerebral cortexExcitatory postsynaptic potentialsAverage reversal potentialCerebral cortexInhibitory neurotransmitterPostsynaptic potentialsLate inhibitory postsynaptic potentialsSlow inhibitory postsynaptic potentialGABAergic inhibitory postsynaptic potentialsInitial excitatory postsynaptic potentialsReversal potentialGABAB agonist baclofenGABAB antagonist phaclofenGABAA antagonist bicucullineGABAA agonist muscimolParoxysmal epileptiform activityMajor inhibitory neurotransmitterVitro. 2Antagonist phaclofenMembrane conductanceAgonist baclofenAntagonist bicuculline
1987
Actions of acetylcholine in the guinea‐pig and cat medial and lateral geniculate nuclei, in vitro.
McCormick D, Prince D. Actions of acetylcholine in the guinea‐pig and cat medial and lateral geniculate nuclei, in vitro. The Journal Of Physiology 1987, 392: 147-165. PMID: 2833597, PMCID: PMC1192298, DOI: 10.1113/jphysiol.1987.sp016774.Peer-Reviewed Original ResearchConceptsRapid excitatory responseSlow depolarizationApplication of acetylcholineLateral geniculate nucleusGeniculate nucleusMuscarinic hyperpolarizationExcitatory responsesMuscarinic receptorsReversal potentialDorsal lateral geniculate nucleusGeniculate neuronesApparent input conductanceSingle spike activityIntracellular recording techniquesAction of acetylcholineACh-induced hyperpolarizationExtrapolated reversal potentialSingle-spike firingMechanism of actionMembrane potentialBath applicationBurst firingBurst dischargesSynaptic transmissionThalamic slices