2012
Warm Body Temperature Facilitates Energy Efficient Cortical Action Potentials
Yu Y, Hill A, McCormick D. Warm Body Temperature Facilitates Energy Efficient Cortical Action Potentials. PLOS Computational Biology 2012, 8: e1002456. PMID: 22511855, PMCID: PMC3325181, DOI: 10.1371/journal.pcbi.1002456.Peer-Reviewed Original ResearchConceptsAction potentialsFiring rateBody temperatureFunctional brain imaging signalsAction potential durationSingle action potentialCortical action potentialsAction potential generationNormal body temperatureSpike firing rateAverage firing rateSpike afterhyperpolarizationEfficient neural codesPotential durationBrain imaging signalsMarked reductionChannel inactivationPotential generationNeural signal transmissionBrain architectureWarmer body temperaturesImaging signalsNeural codeDurationAfterhyperpolarization
2007
Enhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo
Haider B, Duque A, Hasenstaub A, Yu Y, McCormick D. Enhancement of Visual Responsiveness by Spontaneous Local Network Activity In Vivo. Journal Of Neurophysiology 2007, 97: 4186-4202. PMID: 17409168, DOI: 10.1152/jn.01114.2006.Peer-Reviewed Original ResearchConceptsPostsynaptic potentialsVisual responsivenessSpontaneous depolarizationsNetwork activityNeocortical network activityInhibitory synaptic potentialsPrimary visual cortexLocal network activityAction potential generationContrast response functionsCortical neuronsSynaptic potentialsSynaptic transmissionSpontaneous activityMembrane potential depolarizationKetamine-xylazineExtracellular recordingsVisual cortexAction potentialsLocal circuitsIntegrative propertiesSensory responsesPotential depolarizationSlow oscillationsPotential generation
2005
Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks
Hasenstaub A, Shu Y, Haider B, Kraushaar U, Duque A, McCormick D. Inhibitory Postsynaptic Potentials Carry Synchronized Frequency Information in Active Cortical Networks. Neuron 2005, 47: 423-435. PMID: 16055065, DOI: 10.1016/j.neuron.2005.06.016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCerebral CortexCortical SynchronizationExcitatory Postsynaptic PotentialsFerretsIn Vitro TechniquesInterneuronsMaleMembrane PotentialsNerve NetNeural InhibitionNeuronsOscillometryPyramidal CellsReaction TimeRefractory Period, ElectrophysiologicalSynapsesSynaptic TransmissionConceptsInhibitory postsynaptic potentialsHigh-frequency activityPostsynaptic potentialsPyramidal cellsCortical pyramidal cellsAction potential propertiesRecurrent network activityAction potential generationActive cortical networkInhibitory interneuronsCortical functionIntracellular injectionNearby neuronsStrong barragesInhibitory networksCortical networksField potentialsSynaptic conductancesIPSPsInhibitory potentialPotential generationNetwork activitySpike timingMore synchronyVivo
2000
Ionic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons
Brumberg J, Nowak L, McCormick D. Ionic Mechanisms Underlying Repetitive High-Frequency Burst Firing in Supragranular Cortical Neurons. Journal Of Neuroscience 2000, 20: 4829-4843. PMID: 10864940, PMCID: PMC6772270, DOI: 10.1523/jneurosci.20-13-04829.2000.Peer-Reviewed Original ResearchConceptsLayer II/III pyramidal neuronsHigh-frequency burst dischargesAction potential generationAction potentialsPyramidal neuronsCortical neuronsBurst dischargesHigh-frequency burst firingVisual cortical slicesAction potential burstsFirst action potentialBurst-firing modeHigh-frequency burstsPotential generationIonic mechanismsIntrinsic burstsCortical slicesLocal cortical networksBurst firingNeocortical neuronsIntracellular recordingsPostsynaptic neuronsATX IIQX-314Single spiking
1997
Influence of low and high frequency inputs on spike timing in visual cortical neurons.
Nowak L, Sanchez-Vives M, McCormick D. Influence of low and high frequency inputs on spike timing in visual cortical neurons. Cerebral Cortex 1997, 7: 487-501. PMID: 9276174, DOI: 10.1093/cercor/7.6.487.Peer-Reviewed Original ResearchConceptsCortical neuronsAction potentialsFerret visual cortexAction potential dischargeVisual cortical neuronsInterspike intervalsAction potential generationAction potential timingTemporal precisionPostsynaptic potentialsGamma frequency rangeIntracellular recordingsIntracellular injectionVisual cortexPotential dischargeNeuronsVisual stimulationCortical networksRegular spikingSensory stimuliSingle trialHigh temporal precisionPotential timingHigh frequencyPotential generation
1992
Chapter 10 Determination of State-Dependent Processing in Thalamus by Single Neuron Properties and Neuromodulators
MCCORMICK D, STROWBRIDGE B, HUGUENARD J. Chapter 10 Determination of State-Dependent Processing in Thalamus by Single Neuron Properties and Neuromodulators. 1992, 259-290. DOI: 10.1016/b978-0-12-484815-3.50017-7.Peer-Reviewed Original ResearchState-dependent processingRelay neuronsSingle neuron propertiesHyperpolarization-activated cation currentNeuron propertiesThalamic relay neuronsAction potential generationThalamic neuronsCentral neuronsRhythmic burstsNervous systemCation currentSynaptic connectionsPacemaker currentThalamusNeuronsMotor informationPotential generationNeuromodulatorsFunctional consequences